MDM2+/CDK4+/p53+ oral liposarcoma: Case report and review of the literature

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 92, Issue 2, 2001, Pages 194-201

  Nikitakis, Nikolaos G ^a,d   Lopes, Marcio A ^b   Pazoki, Alexander E ^c   Robert A, Ord ^c   Sauk, John J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSITY OF MARYLAND   (United States)

^d UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CDK4 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; DNA; MDM2 PROTEIN, HUMAN; MEMBRANE PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2; SAS PROTEIN, HUMAN; TUMOR PROTEIN;

ADULT; CASE REPORT; DIFFERENTIAL DIAGNOSIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LIPOSARCOMA; MALE; MOUTH TUMOR; PATHOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS; REVIEW; TUMOR SUPPRESSOR GENE;

ADULT; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LIPOSARCOMA; MALE; MEMBRANE PROTEINS; MOUTH NEOPLASMS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2;

EID: 0035433637     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1067/moe.2001.116815     Document Type: Article

References (59)

1. Enzinger FM, Weiss SW. Liposarcoma. In: Gay SM, ed. Soft tissue tumors. 3rd ed. St Louis: Mosby-Year Book; 1995. p. 431-66.
2. Pack GT, Pierson JC. Liposarcoma. A study of 105 cases. Surgery 1954;36:687-712.
3. Stout AP. Liposarcoma - the malignant tumor of lipoblasts. Ann Surg 1944;119:86-107.
4. Enterline HT, Culberson JD, Rochlin DB, Brady LW. Liposarcoma. A clinical and pathological study of 53 cases. Cancer 1960;13:932-50.
5. Hasegawa H, Kawakami T, Eda S. Mixed-type liposarcoma of the oral cavity: a case with unusual features and a long survival. J Oral Pathol Med 1999;28:141-4.
6. Sauk JJ Jr. Liposarcoma of the head and neck. J Oral Surg 1971;29:38-40.
7. Henefer EP, Borghesani EP, Sacks FR. Liposarcoma of the cheek. J Oral Surg 1976;34:1039-43.
8. Larson DL, Cohn AM, Estrada RG. Liposarcoma of the tongue. J Otolaryngol 1976;5:410-4.
9. Baden E, Newman R. Liposarcoma of the oropharyngeal region. Review of the literature and report of two cases. Oral Surg Oral Med Oral Pathol 1977;44:889-902.
10. Ramon Y, Horowitz Y, Oberman M, Freedman A. Liposarcoma of the buccal mucosa. Int J Oral Surg 1977;6:226-8.
11. Amarjit S, Singh A, Nagpal BL, Gambir GS. Liposarcoma of the cheek. J Oral Surg 1978;36:811-3.
12. Hudson C, Cove P, Adekeye EO. Liposarcoma of the head and neck: report of case and review of the literature. J Oral Surg 1978;36:380-3.
13. Adkins WY Jr, Putney FJ, Kreutner A, Cunningham C. Liposarcoma of the maxilla. Otolaryngology 1978;86:ORL-710-3.
14. Saunders JR, Jaques DA, Casterline PF, Percarpio B, Goodloe S Jr. Liposarcomas of the head and neck: a review of the literature and addition of four cases. Cancer 1979;43:162-8.
15. Yamada K, Dohara Y, Nagata M, Kawashima K, Yamashita S. A case of liposarcoma of the cheek. Jap J Clin Oncol 1979;9:123-30.
16. Amarjit S, Bhardwaj DN, Nagpal BL. Intraosseous liposarcoma of the maxilla and mandible: report of two cases. J Oral Surg 1979;37:593-6.
17. Sadeghi EM, Sauk JJ Jr. Liposarcoma of the oral cavity. Clinical, tissue culture, and ultrastructure study of a case. J Oral Pathol 1982;11:263-75.
18. Suzuki H, Nagayama M, Kaneda T, Oka T. Liposarcoma of the cheek in an infant. J Oral Maxillofac Surg 1984;42:180-4.
19. Wescott WB, Correll RW. Multiple recurrences of a lesion at the base of the tongue. J Am Dent Assoc 1984;108:231-2.
20. Watanabe I, Satoh M, Yamane G, Horiuchi T, Shimono M. Liposarcoma arising from the cheek of the aged: report of a case and review of the literature. Gerodontics 1985;1:148-51.
21. Hanada M, Tokuda R, Ohnishi Y, Takami M, Takahashi T, Kimura M. Benign lipoblastoma and liposarcoma in children. Acta Pathol Jpn 1986;36:605-12.
22. Dominguez FV, Guglielmotti MB, Flores MC, de la Garza MLG. Myxoid liposarcoma of the cheek. J Oral Maxillofac Surg 1990;48:395-7.
23. Eidinger G, Katsikeris N, Gullane P. Liposarcoma: report of a case and review of the literature. J Oral Maxillofac Surg 1990;48:984-8.
24. Charnock DR, Jett T, Heise G, Taylor R. Liposarcoma arising in the cheek: report of a case and review of the literature. J Oral Maxillofac Surg 1991;49:298-300.
25. Azaz B, Casap N. Myxoid liposarcoma of the buccal vestibule. A case report. Int J Oral Maxillofac Surg 1991;20:308-9.
26. Guest PG. Liposarcoma of the tongue: a case report and review of the literature. Br J Oral Maxillofac Surg 1992;30:268-9.
27. Ruacan S, Onerci M, Gedikoglu G, Dal T. Liposarcoma of the cheek: report of a case. J Oral Pathol Med 1993;22:46-7.
28. La Quaglia MP, Spiro SA, Ghavimi F, Hajdu SI, Meyers P, Exelby PR. Liposarcoma in patients younger than or equal to 22 years of age. Cancer 1993;72:3114-9.
29. Lucas DR, Nascimento AG, Sanjay BKS, Rock MG. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol 1994;102:677-83.
30. Zheng JW, Wang Y. Liposarcoma in the oral and maxillofacial region: an analysis of 10 consecutive patients. J Oral Maxillofac Surg 1994;52:595-8.
31. Nakahara H, Shirasuna K, Terada K. Liposarcoma of the floor of the mouth: a case report. J Oral Maxillofac Surg 1994;52:1322-4.
32. Minic AJ. Liposarcomas of the oral tissues: a clinicopathologic study of four tumors. J Oral Pathol Med 1995;24:180-4.
33. Saddik M, Oldring DJ, Mourad WA. Liposarcoma of the base of tongue and tonsillar fossa. A possibly underdiagnosed neoplasm. Arch Pathol Lab Med 1996;120:292-5.
34. Senyuva C, Yucel A, Okur I, Dervisoglu S. A well-differentiated giant liposarcoma originating from the buccal fat pad. Ann Plast Surg 1996;37:439-43.
35. Kamikaidou N, Kirita T, Mishima K, Sugimura M. Liposarcoma of the cheek: report of a case. J Oral Maxillofac Surg 1998;56:662-5.
36. Govender D, Pillay P. Primary myxoid liposarcoma with rhabdomyoblastic differentiation. Arch Pathol Lab Med 1998;122:740-2.
37. Nelson W, Chuprevich T, Galbraith DA. Enlarging tongue mass. J Oral Maxillofac Surg 1998;56:224-7.
38. Gagari E, Kabani S, Gallagher GT. Intraoral liposarcoma: case report and review of the literature. Oral Surg Oral Med Oral Pathol Radiol Endod 2000;89:66-72.
39. Piattelli A, Di Alberti L, Favia GF. Liposarcoma involving the periodontal tissues. A case report. J Periodontol 2000;71:322-4.
40. Osborn M, Iseberg S. Immunocytochemistry of frozen and of paraffin tissue sections. In: Cell biology: a laboratory handbook. London: Academic Press; 1994:361-7.
41. Sambrook J, Fritsch EF, Maniatis T. In: Nolan C, ed. Molecular cloning: a laboratory manual. 2nd ed. New York: Cold Spring Harbor Laboratory Press; 1989.
42. Golledge J, Fisher C, Rhys-Evans PH. Head and neck liposarcoma. Cancer 1995;76:1051-8.
43. McCulloch TM, Makielski KH, McNutt MA. Head and neck liposarcoma. A histopathologic reevaluation of reported cases. Arch Otolaryngol Head Neck Surg 1992;118:1045-9.
44. Enzinger FM, Weiss SW. Liposarcoma. In: Stamathis G, ed. Soft tissue tumors. 2nd ed. St. Louis: CV Mosby; 1988:346-82.
45. Rosai J, Akerman M, Dal Cin P, DeWever I, Fletcher CD, Mandahl N, et al. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group). Am J Surg Pathol 1996;20:1182-9.
46. Pilotti S, Della Torre G, Lavarino C, Di Palma S, Sozzi G, Minoletti F, et al. Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. J Pathol 1997;181:14-24.
47. Tallini G, Akerman M, Dal Cin P, DeWever I, Fletcher CD, Mandahl N, et al. Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing (a report from the CHAMP Group). Am J Surg Pathol 1996;20:1047-55.
48. Thelin-Jarnum S, Lassen C, Panagopoulos I, Mandahl N, Aman P. Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas. Int J Cancer 1999;83:30-3.
49. Dei Tos AP, Doglioni C, Piccinin S, Maestro R, Mentzel T, Barbareschi M, et al. Molecular abnormalities of the p53 pathway in dedifferentiated liposarcomas. J Pathol 1997;181:8-13.
50. Hisaoka M, Tsuji S, Morimitsu Y, Hashimoto H, Shimajiri S, Komiya S, et al. Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Diagn Mol Pathol 1998;7:96-101.
51. Pilotti S, Della Torre G, Lavarino C, Sozzi G, Minoletti F, Vergani B, et al. Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22. J Pathol 1998;185:188-90.
52. Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, et al. p53 mutation and MDM2 amplification in human soft tissues sarcomas. Cancer Res 1993;53:2231-4.
53. Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki MS. MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. Int J Cancer 1995;64:342-6.
54. Nilbert M, Rydholm A, Mitelman F, Meltzer PS, Mandahl N. Characterization of the 12q13-15 amplicon in soft tissue tumors. Cancer Genet Cytogenet 1995;83:32-6.
55. Kanoe H, Nakayama T, Murakami H, Hosaka T, Yamamoto H, Nakashima Y, et al. Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. Anticancer Res 1998;18:2317-21.
56. Jankowski SA, Mitchell DS, Smith SH, Trent JM, Meltzer PS. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene 1994;9:1205-11.
57. Jankowski SA, De Jong P, Meltzer PS. Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas. Genomics 1995;25:501-6.
58. Pilotti S, Lavarino C, Mezzelani A, Della Torre C, Minoletti F, Sozzi G, et al. Limited role of TP53 and TP53-related genes in myxoid liposarcoma. Tumori 1998;84:571-7.
59. Dei Tos AP, Piccinin S, Doglioni C, Vukosavljevic T, Mentzel T, Boiocchi M, et al. Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma. Am J Pathol 1997;151:1531-9.