The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma

Cancer

Volumn 92, Issue 3, 2001, Pages 488-499

  Ikeda, Naoya ^a   Nakajima, Yoshiyuki ^b   Sho, Masayuki ^c   Adachi, Masashi ^c   Huang, Cheng Long ^a   Iki, Katsumichi ^b   Kanehiro, Hiromichi ^c   Hisanaga, Michiyoshi ^c   Nakano, Hiroshige ^c   Miyake, Masayuki ^a  

^a Kitano Hospital   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Angiogenesis; K ras; Pancreatic carcinoma; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE K RAS; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ENDOTHELIAL GROWTH FACTORS; FEMALE; GENE EXPRESSION; GENES, RAS; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MALE; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035425191     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20010801)92:3<488::AID-CNCR1347>3.0.CO;2-F     Document Type: Article

References (43)

1. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
2. Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving?
3. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer
4. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
5. Ras oncogenes in human cancer: A review
6. What is the evidence that tumors are angiogenesis dependent?
7. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
8. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer
9. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
10. Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage
11. Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness
12. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
13. Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma
14. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
15. Prognostic significance of angiogenesis in human pancreatic cancer
16. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
17. Molecular and biological properties of the vascular endothelial growth factor family of proteins
18. Oncogenes as inducers of tumor angiogenesis
19. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
20. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
21. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
22. Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
23. Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
24. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
25. Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer
26. Molecular structure of the human cytoplasmic beta-actin gene: Interspecies homology of sequences in the introns
27. Cathepsin D and prognosis in breast cancer
28. Human-tumor-derived cell lines contain common and different transforming genes
29. Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy
30. Evaluation of survival data and two new rank order statistics arising in its consideration
31. Regression models and life-tables
32. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
33. Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis
34. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
35. The ras signal transduction pathway
36. The role of p21 ras in receptor tyrosine kinase signalling
37. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
38. K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: Diagnostic utility and prognostic significance
39. Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma
40. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
41. KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells
42. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders