Identification and location of a cysteinyl posttranslational modification in an amyloidogenic κ1 light chain protein by electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry

Analytical Biochemistry

Volumn 295, Issue 1, 2001, Pages 45-56

  Lim, Amareth ^a   Wally, Jeremy ^a   Walsh, Mary T ^a   Skinner, Martha ^a   Costello, Catherine E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloidosis; Cysteinylation; Disulfide bonds; Immunoglobulin; Peptide mapping

Indexed keywords

AMINO ACIDS; COVALENT BONDS; DESORPTION; DISEASES; GLYCOPROTEINS; LYMPHOCYTES; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PATIENT MONITORING; PURIFICATION; REDUCING AGENTS; SENSITIVITY ANALYSIS; SULFUR COMPOUNDS;

AMYLOIDOSIS; CYSTEINYLATION; DISULFIDE BONDS; IMMUNOGLOBULIN; PEPTIDE MAPPING;

ELECTROSPRAY IONIZATION;

IMMUNOGLOBULIN LIGHT CHAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOIDOSIS; ARTICLE; BIREFRINGENCE; CONFORMATIONAL TRANSITION; DISULFIDE BOND; HUMAN; HUMAN CELL; MOLECULAR CLONING; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PURIFICATION;

EID: 0035423710     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2001.5187     Document Type: Article

References (54)

1. Alternative conformations of amyloidogenic proteins govern their behavior
2. Amyloid fibrillogenesis: Themes and variations
3. Protein and host factors implicated in the pathogenesis of light chain amyloidosis (AL amyloidosis)
4. The systemic amyloidoses
5. Immunoglobulin light chain amyloidosis - The archetype of structural and pathogenic variability
6. A role for destabilizing amino acid replacements in light-chain amyloidosis
7. Specificity of abnormal assembly in immunoglobulin light chain deposition disease and amyloidosis
8. Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains
9. Amyloid fibril proteins: Proof of homology with immunoglobulin light chains by sequence analyses
10. Morphologic, chemical, and immunologic studies of amyloid-like fibrils formed from Bence Jones proteins by proteolysis
11. Isolation and characterization of a κ amyloid fibril protein
12. Polymorphism in a kappa I primary (AL) amyloid protein (BAN)
13. Amino acid sequence of a κ Bence Jones protein from a case of primary amyloidosis
14. Structural identity of Bence Jones and amyloid fibril proteins in a patient with plasma cell dyscrasia and amyloidosis
15. Complete amino acid sequence determinations demonstrate identity of the urinary Bence Jones protein (BJP-DIA) and the amyloid fibril protein (AL-DIA) in a case of AL-amyloidosis
16. Constant region of a κ III immunoglobulin light chain as a major AL-amyloid protein
17. Light chain-associated amyloid deposits comprised of a novel κ constant domain
18. Structural analysis of the amyloidogenic κ Bence Jones protein (FUR)
19. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic κ1 light chain
20. Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: Association with dominant amyloid-related organ involvement and survival after stem cell transplantation
21. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments
22. Strategies for locating disulfide bonds in proteins
23. Assignment of the disulfide bonds in napin, a seed storage protein from Brassica napus, using matrix-assisted laser desorption ionization mass spectrometry
24. A novel methodology for assignment of disulfide bond pairings in proteins
25. Strategies for locating disulfide bonds in a monoclonal antibody via mass spectrometry
26. Mass spectrometry unravels disulfide bond formation as the mechanism that activates a molecular chaperone
27. Electrospray ionization for mass spectrometry of large biomolecules
28. Laser desorption ionization of proteins with molecular masses exceeding 10,000 Daltons
29. Sodium trifluoroacetate as a tune/calibration compound for positive- and negative-ion electrospray ionization mass spectrometry in the mass range of 100-4000 Da
30. Mass resolution improvement by incorporation of pulsed ion extraction in a matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometer
31. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry
32. The amino acid sequence of a κ type Bence-Jones protein
33. Prompt fragmentation of disulfide-linked peptides during matrix-assisted laser desorption ionization mass spectrometry
34. Facile, in situ matrix-assisted laser desorption ionization-mass spectrometry analysis and assignment of disulfide pairings in heteropeptide molecules
35. Disulphide interchange reactions
36. Disulphide bridges and dimers of Bence-Jones protein
37. Interchain disulphide bridge in Bence-Jones proteins and in γ-globulin B chains
38. Manifestations of systemic light chain deposition
39. Light chain deposition disease derived from the κ1 light chain subgroup
40. Monoclonal immunoglobulin deposition disease: Light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis
41. Inter heavy-light chain disulphide bridge in immune globulins
42. A case of tetramer Bence Jones proteinaemia
43. Polymeric forms of free normal κ and λ chains of human immunoglobulin
44. Amyloidosis: Its nature and pathogenesis
45. Patterns of amyloidosis and their association with plasma-cell dyscrasia, monoclonal immunoglobulins and Bence-Jones proteins
46. Bence Jones proteins and light chains of immunoglobulins
47. Tertiary structure of an amyloid immunoglobulin light chain protein: A proposed model for amyloid fibril formation
48. A molecular model for self-assembly of amyloid fibrils: Immunoglobulin light chains
49. Glycopeptides from human κ-chains
50. The amino-acid sequence of the variable region of a carbohydrate-containing amyloid fibril protein EPS (immunoglobulin light chain, type λ)
51. A glycosylated Bence Jones protein and its autologous amyloid light chain containing potentially amyloidogenic residues
52. Glycosylation of immunoglobulin light chains associated with amyloidosis
53. Reduction of disulfide bonds in an amyloidogenic Bence Jones protein leads to formation of "amyloid-like" fibrils in vitro