Male sterility associated with overexpression of the noncoding hsr ω gene in cyst cells of testis of Drosophila melanogaster

Journal of Genetics

Volumn 80, Issue 2, 2001, Pages 97-110

  Rajendra, T K ^a   Prasanth, K V ^a   Lakhotia, S C ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

93D; Heat shock; hnRNP; Omega speckles; Sperm individualization; Spermatogenesis

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; UNTRANSLATED RNA;

ANIMAL; ARTICLE; CYTOLOGY; DROSOPHILA MELANOGASTER; FEMALE; FERTILITY; GENE; GENE EXPRESSION; GENETICS; HEAT SHOCK RESPONSE; HISTOLOGY; MALE; METABOLISM; MUTATION; PHYSIOLOGY; SPERMATOCYTE; SPERMATOGENESIS; TESTIS; TRANSPOSON;

ANIMALS; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; FEMALE; FERTILITY; GENE EXPRESSION; GENES, INSECT; HEAT-SHOCK RESPONSE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; MALE; MUTATION; RIBONUCLEOPROTEINS; RNA, UNTRANSLATED; RNA-BINDING PROTEINS; SPERMATOCYTES; SPERMATOGENESIS; TESTIS;

EID: 0035413670     PISSN: 00221333     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02728335     Document Type: Article

References (48)

1. Baker B. S. 1989 Sex in flies: the splice of life. Nature 340, 521-524.
2. Bendena W. G., Ayme-Southgate A., Garbe J. C. and Pardue M. L. 1991 Expression of heat-shock locus hsr-omega in non-stressed cells during development in Drosophila melanogaster. Dev. Biol. 144, 65-77.
3. Bier E., Vaeddin H., Shepherd S., Lee K., McCall K., Barbel S., Ackerman L., Carretto R., Uemura T., Grell E., Jan L. Y. and Jan Y. N. 1989 Searching for pattern and mutation in the Drosophila genome with a P-LacZ vector. Genes Dev. 3, 1273-1287.
4. Bonaccorsi S., Pisano C., Puoti F. and Gatti M. 1988 Y chromosome loops in Drosophila melanogaster. Genetics 120, 1015-1034.
5. Bopp D., Bell L. R., Cline T. W. and Schedl P. 1991 Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster. Genes Dev. 5, 403-415.
6. Buchenau P., Saumweber H. and Arndt-Jovin D. J. 1997 The dynamic nuclear redistribution of an hnRNP K-homologous protein during Drosophila embryo development and heat shock. Flexibility of transcription sites in vivo. J. Cell Biol. 137, 291-303.
7. Champlin D. T., Frasch M., Saumwebcr H. and Lis J. T. 1991 Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin. Genes Dev. 5, 1611-1621.
8. Dangli A. and Bautz E. K. F. 1983 Differential distribution of nonhistone proteins from polytene chromosomes of Drosophila melanogaster after heat shock. Chromosoma 88, 201-207.
9. Eggert M., Michel J., Schneider S., Bornfleth H., Baniahmad A., Facklemayer F. O., Schmidt S. and Renkawitz R. 1997 The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J. Biol. Chem. 272, 28471-28478.
10. Facklemayer F. O., Dahm K., Renz A., Ramsperger U. and Richter A. 1994 Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear matrix protein which binds to DNA and RNA in vivo and in vitro. Eur. J. Biochein. 211, 749-757.
11. Fuller M. 1993 Spermatogenesis. In The development of Drosophila melanogaster (ed. M. Bate and A. Martinez). pp. 71-147. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
12. Garbe J. C., Bendena W. H. and Pardue M. L. 1986 A Drosophila heat shock gene with a rapidly diverging sequence but a conserved structure. J. Biol. Chem. 261, 16889-16894.
13. Gohring F. and Facklemayer F. O. 1997 The scaffold/matrix attachment region binding protein hnRNP-U SAF-A is directly bound to chromosomal DNA in vivo: a chemical cross-linking study. Biochemistry 36, 8276-8283.
14. Heatwole V. M. and Haynes S. R. 1996 Association of RB97D an RRM protein required for male fertility with a Y chromosome lampbrush loop in Drosophila spcrmatocytes. Chromosoma 105, 285-292.
15. Hennig W. 1999 Y chromosomal fertility genes in Drosophila. Curr. Sci. 77, 550-552.
16. Hime G. R., Brill J. A. and Fuller M. T. 1998 Assembly of ring canals in the male germ line from structural components of the contractile ring. J. Cell Sci. 100, 2779-2788.
17. Holzmann K., Korosec T., Gerner C., Grimm R. and Sauermann G. 1997 Identification of human common nuclear-matrix proteins as heterogeneous nuclear ribonuclcoproteins H and H′ by sequencing and mass spectrometry. Eur. J. Biochem. 244, 479-486.
18. Hovemann B. T., Dessen E., Mechler H. and Mack E. 1991 Drosophila snRNP associated protein P11 which specifically binds to heat shock puff 93D reveals strong homology with hnRNP core protein A1. Nucl. Acids Res. 19, 4909-4919.
19. Hovemann B. T., Reim., Werner S., Katz S. and Saumweber H. 2000 The protein Hrb57A of Drosophila melanogaster closely related to hnRNP K from vertebrates is present at sites active in transcription and coprecipitates with four RNA-binding proteins. Gene 245, 127-137.
20. Kimble M., Dettman R. W. and Raff E. C. 1990 The β3-tubulin gene of Drosophila melanogaster is essential for viability and fertility. Genetics 126, 991-1005.
21. Krecic A. M. and Swanson M. S. 1999 hnRNP complexes: composition, structure and function. Curr. Opin. Cell Biol. 11, 363-371.
22. Lakhotia S. C. and Mukherjee A. S. 1970 Activation of a specific puff by benzamide in Drosophila melanogaster. Dros. Infor. Ser. 45, 108.
23. Lakhotia S. C. and Sharma A. 1995 RNA metabolism in situ at the 93D heat shock locus in polytene nuclei of Drosophila melanogaster after various treatments. Chromosome Res. 3, 151-161.
24. Lakhotia S. C. and Sharma A. 1996 The 93D hsr-omega locus of Drosophila: non-coding gene with house keeping functions. Genetica 97, 339-348.
25. Lakhotia S. C. and Singh B. N. 1993 A simple and inexpensive "Western-blotting" apparatus. Indian J. Exp. Biol. 31, 301-302.
26. Lakhotia S. C. and Tapadia M. G. 1998 Genetic mapping of the amide response element/s of the hsrω locus of Drosophila melanogaster. Chromosoma 107, 127-135.
27. Lakhotia S. C., Ray P., Rajendra T. K. and Prasanth K. V. 1999 The non-coding transcripts of hsr-omega gene in Drosophila: Do they regulate trafficking and availability of nuclear RNA-processing factors? Curr. Sci. 77, 553-563.
28. Lakhotia S. C., Rajendra T. K. and Prasanth K. V. 2001 Developmental regulation and complex organization of the promoter of the non-coding hsrω gene of Drosophila melanogaster. J. Biosci. 21, 25-38.
29. Lindsley D. L. and Tokuyasu K. T. 1980 Spermatogenesis. In The genetics and biology of Drosophila, 2nd edition (ed. M. Ashburner and T. R. Wright), pp. 225-294. Academic Press, New York.
30. Lindsley D. L. and Zimm G. G. 1992 The genome of Drosophila melanogaster. Academic Press, San Diego.
31. Lu X., Timchenko N. A. and Timchenko L. T. 1999 Cardiac elav-type RNA-binding protein ETR-3 binds to RNA CUG repeats expanded in myotonic dystrophy. Hum. Mol. Genet. 8, 53-60.
32. Mattern K. A., Humbel B. M., Muijsers A. O., de Jong L. and van Driel R. 1996 hnRNP proteins and B23 are the major proteins of the internal nuclear matrix of HeLa S3 cells. J. Cell. Biochem. 62, 275-289.
33. Matunis E. L., Matunis M. L. and Dreyfuss G. 1992 Characterization of the major hnRNP proteins from Drosophila melanogaster. J. Cell Biol. 116, 257-269.
34. Misteli T. and Spector D. L. 1997 Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Trends Cell Biol. 7, 135-138.
35. Mohler J. and Pardue M. L. 1984 Mutational analysis of the region surrounding the 93D heat shock locus of Drosophila melanogaster. Genetics 106, 249-265.
36. Mutsuddi M. and Lakhotia S. C. 1995 Spatial expression of the hsr-omega 93D gene in different tissues of Drosophila melanogaster and identification of promoter elements controlling its developmental expression. Dev. Genet. 17, 303-311.
37. Philips A. V., Timchenko L. T. and Cooper T. 1998 Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280, 737-740.
38. Prasanth K. V., Rajendra T. K., Lal A. K. and Lakhotia S. C. 2000 Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with non-coding hsr-omega RNA in Drosophila. J. Cell Sci. 113, 3485-3497.
39. Ryseck R.-P., Walldorf U., Hoffmann T. and Hovemann B. 1987 Heat shock loci 93D of Drosophila inelanogaster and 48B of Drosophila hydei exhibit a common structural and transcriptional pattern. Nucl. Acids Res. 15, 3317-3333.
40. Salz H. K., Cline T. W. and Schedl P. 1987 Functional changes associated with structural alterations induced by mobilization of a P element inserted in the Sex-lethal gene of Drosophila. Genetics 117, 221-231.
41. Samuels M. E., Bopp D., Colvin R. A., Roscigno R. F., Garcia-Blanco M. A. and Schedl P. 1994 RNA binding by Sxl proteins in vitro and in vivo. Mol. Cell. Biol. 14, 4975-4990.
42. Saumweber H., Symmons P., Kubisch R., Will H. and Bonhoeffer F. 1980 Monoclonal antibodies against chromosomal proteins of Drosophila melanogaster. Chromosoma 80, 253-275.
43. Singer R. H. 1998 Triplet-repeat transcripts: A role for RNA in disease. Science 280, 696-697.
44. Spradling A. C., Stern D. M., Kiss I., Roote J., Laverty T. and Rubin G. M. 1995 Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc. Natl. Acad. Sci. USA 92, 10824-10830.
45. Velazquez J. and Lindquist S. 1984 Hsp70: nuclear concentration during environmental stress and cytoplasmic storage during recovery. Cell 36, 655-632.
46. Venables J. P. and Eperon I. C. 1999 The roles of RNA-binding proteins in spermatogenesis and male infertility. Curr. Opin. Genet. Dev. 9, 346-354.
47. Weighardt F., Balmonti G. and Riva S. 1996 The role of heterogeneous nuclear ribonucleoproteins hnRNP in RNA metabolism. BioEssays 18, 747-756.
48. Weighardt F., Cobianchi F., Cartegni L., Chiodi I., Villa A., Riva S. and Biamonti G. 1999 A novel hnRNP protein HAP/ SAF-B enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock. J. Cell Sci. 112, 1465-1476.