Extended exposure of adult and fetal mice to 50 Hz magnetic field does not increase the incidence of micronuclei in erythrocytes

Bioelectromagnetics

Volumn 22, Issue 5, 2001, Pages 351-357

  Abramsson Zetterberg, L ^a,b   Grawe J ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL FOOD ADMINISTRATION   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Chromosome effects; EMF; Flow cytometry; Genetic effects; Prenatal mice; Stem cells

Indexed keywords

BLOOD; CHROMOSOMES; CYTOLOGY; FLOW CYTOMETRY; MAGNETIC FIELD EFFECTS; MAMMALS;

ADULT MICE; CHROMOSOME EFFECT; CYTOMETERS; ERYTHROID CELLS; GENETIC EFFECTS; MAGNETIC-FIELD; PEAK-TO-PEAK; PERIPHERAL BLOOD; PRENATAL MOUSE; STEM-CELL;

STEM CELLS;

ANIMALIA;

ANIMAL; ARTICLE; CBA MOUSE; CYTOLOGY; ERYTHROCYTE; FEMALE; FETUS BLOOD; GAMMA RADIATION; MAGNETISM; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; PREGNANCY; RADIATION EXPOSURE; ULTRASTRUCTURE;

ANIMALS; ERYTHROCYTES; FEMALE; FETAL BLOOD; GAMMA RAYS; MAGNETICS; MALE; MICE; MICE, INBRED CBA; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; PREGNANCY;

EID: 0035406899     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/bem.61     Document Type: Article

References (39)

1. 137Cs at very low dose rates. Int J Radiat Biol 67:29-36.
2. Abramsson-Zetterberg L. 1996. Ascorbic acid is not clastogenic and does not modify the effect of extended low-dose-rate y-irradiation in mouse bone marrow. Int J Radiat Biol 70: 77-81.
3. Abramsson-Zetterberg L, Zetterberg G, Sundell-Bergman S, Grawé J. 2000. Absence of genomic instability in mice following prenatal low dose-rate y-irradiation. Int J Radiat Biol 76:971-977.
4. Bolognesi C, Abbondandolo A, Barale R, Casalone R, Dalpra LD, Ferrari M, Degrassi F, Forni A, Lamberti L, Lando C, Migliore L, Padovani P, Pasquini R, Puntoni R, Sbrana I, Stella M, Bonassi S. 1997. Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol Biomarkers Prev 6:249-256.
5. Dass SB, Ali SF, Heflich RH, Casciano DA. 1997. Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice. Mutat Res 381:105-110.
6. Dutkowski RT, Lesh R, Staiano-Coico L, Thaler H, Darlington GJ, Weksler ME. 1985. Increased chromosomal instability in lymphocytes from elderly humans. Mutat Res 149:505-512.
7. El Nahas SM, Oraby HA. 1989. Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields. Environ Mol Mutagen 13:107-111.
8. Fenech M, Morley AA. 1985. The effect of donor age on spontaneous and induced micronuclei. Mutat Res 148:99-105.
9. Grawé J, Abramsson-Zetterberg L and Zetterberg G. 1998. Low dose effects of chemicals as assessed by the flow cytometric in vivo micronucleus assay. Mutat Res 405:199-208.
10. Grawé J, Zetterberg G, Amnéus H. 1992. Flow-cytometric enumeration of micronucleated polychromatic erythrocytes in mouse peripheral blood. Cytometry 13:750-758.
11. Grawé J, Zetterberg G, Amnéus H. 1993. DNA content determination of micronucleated polychromatic erythrocytes induced by clastogens and spindle poisons in mouse bone marrow and peripheral blood. Mutagenesis 8:249-255.
12. Harms-Ringdahl M. 1998. Some aspects on radiation induced transmissible genomic instability. Mutat Res 404:27-33.
13. Harris G, Holmes A, Sabovljev SA, Cramp WA, Hedges M, Hornsey S, Hornsey JM, Bennett GC. 1986. Sensitivity to X-irradiation of peripheral blood lymphocytes from ageing donors. Int J Radiat Biol 50:685-694.
14. Holmberg K. 1999. Chromosomal instability induced by ionizing radiation in human T-lymphocytes. Licensiate thesis, Department of Biosciences at Novum, Environmental Medicine Unit, Karolinska Institutet, Huddinge, Stockholm, Sweden.
15. Huuskonen H, Juutilainen J, Julkunen A, Mäki-Paakkanen J, Komulainen H. 1998. Effects of low-frequency magnetic fields on fetal development in CBA/Ca mice. Bioelectromagnetics 19:477-485.
16. Ilyinskikh NN, Eremich AV, Ivanchuk II, Ilyinskikh EN. 1996. Micronucleus test of erythrocytes and lymphocytes in the blood of the people living in the radiation pollution zone as a result of the accident at the Siberian chemical plant on April 6, 1993. Mutat Res 361:173-178.
17. Kroneberg A. 1994. Radiation-induced genomic instability. Int J Radiat Biol 66:603-609.
18. Lai H, Singh NP. 1997a. Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics 18(6):446-454.
19. Lai H, Singh NP. 1997b. Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells. J Pineal Res 22(3):152-162.
20. Lezhava TA. 1984. Heterochromatinization as a key factor in aging. Mech Ageing Dev 28:279-287.
21. Little JB. 1998. Radiation-induced genomic instability. Int J Radiat Biol 74:663-671.
22. Lowe X, Collins B, Allen J, Titenko-Holland N, Breneman J, van Beek M, Bishop J, Wyrobek AJ. 1995. Aneuploidies and micronuclei in the germ cells of male mice of advanced age. Mutat Res 338:59-76.
23. McCann J, Dietrich F, Rafferty C. 1998. The genotoxic potential of electric and magnetic fields: an update. Mutat Res 411(1): 45-86.
24. Migliore L, Parrini M, Sbrana I, Biagini A, Battaglia A, Loprieno N. 1991. Micronucleated lymphocytes in people occupationally exposed to potential environmental contamitants: the age effect. Mutat Res 256:13-20.
25. Morales-Ramirez P, Vallarino-Kelly T, Mercader-Maitinez J, Rodriguez-Reyes R. 1994. Induction of micronuclei by acute and chronic exposure in vivo to gamma rays in inurine polychromatic erythrocytes. Mutat Res 341:47-55.
26. Natarajan AT, Vyas RC, Wiegant J, Curado MP. 1991. A cytogenetic follow-up study of the victims of a radiation accident in Goiania (Brazil). Mutat Res 247:103-111.
27. Nath J, Tucker JD, Hando JC. 1995. Y chromosome aneuploidy, micronuclei, kinetochores and aging in men. Chromosoma 103:725-731.
28. Nomoto S, Ootsuyama A, Shioyama Y, Katsuki M, Kondo S, Norimura T. 1998. The high susceptibility of heterozygous p53(±) mice to malformation after foetal irradiation is related to sub-competent apoptosis. Int J Radiat Biol 744:19-29.
29. Paashuis-Lew YRM, Heddle JA. 1998. Spontaneous mutation during fetal development and post-natal growth. Mutagenesis 13:613-617.
30. Potten CS, Booth C, Pritchard DM. 1997. The intestinal epithelial stem cell: the mucosal governor. Int J Pathol 78:219-243.
31. Ramsey MJ, Moore DH 2nd, Briner JF, Lee DA, Olsen L, Senft JR, Tucker JD. 1995. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat Res 338:95-106.
32. Rosemann M, Millier A, Lambert BE. 1999. Chromosomal instability in haemopoietic cells of the foetus, mother and offspring after in utero irradiation of the CBA/Ca mouse. Int J Radiat Biol 75:601-607.
33. Sato S, Taketomi M, Nakajima M, Kitazawa M, Shimada H, Itoh S, Igarashi M, Higashikuni N, Suton S, Sasaki YF. 1995. Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS.MMS. Collaborative Study Group for the Micronucleus Test. Environmental Mutagen Society of Japan. Mammalian Mutagenesis Study Group. Mutat Res 338:51-57.
34. Sevaǹkaev AV, Lloyd DC, Potetnya OI, Zhloba AA, Moiseenko W, Edwards AA. 1995. Chromosomal aberrations in lymphocytes of residents of areas contaminated by radioactive discharses from the Cheniobyl accident. Radiat Prot Dosim 58:247-254.
35. Skyberg K, Hansteen IL, Vistnes AI. 1993. Chromosome aberrations in lymphocytes of high-voltage laboratory cable splicers exposed to electromagnetic fields. Scand J Work Environ Health 19(1):29-34.
36. Svedenstål BM, Johanson CJ. 1998. Leukocytes and micronucleated erythrocytes in peripheral blood from mice exposed to 50 Hz or 20-kHz magnetic fiald. Electro- and magneto-biology 17:127-143.
37. Valjus J, Norppa H, Jarventaus H, Sorsa M, Nykyri E, Salomaa S, Jarvinen P, Kajander J. 1993. Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields. Radiat Environ Biophys 32:325-336.
38. Weirich-Schwaiger H, Weirich HG, Gruber B, Schweiger M, Hirsch-Kauffmann M. 1994. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat Res 316:37-48.
39. Wright EG. 1999. Inherited and inducible chromosomal instability: a fragile bridge between genome integrity mechanisms and tumourigenesis. J Pathol 187:19-27.