Geographic differences and the role of cagA gene in gastroduodenal diseases associated with Helicobacter pylori infection

Revista Espanola de Enfermedades Digestivas

Volumn 93, Issue 7, 2001, Pages 476-480

  Valmaseda Perez T ^a,b   Gisbert, J P ^b   Pajares Garcia J M ^b  

^a FINLAY INSTITUTE   (Cuba)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

CagA; Duodenal ulcer; Gastric cancer; Gastric ulcer; Gastritis; Helicobacter pylori; Peptic ulcer; Virulence

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI;

BACTERIAL GENE; GASTRITIS; GENETIC MARKER; GENETICS; HELICOBACTER PYLORI; HUMAN; MICROBIOLOGY; PATHOGENICITY; PHENOTYPE; PHYSIOLOGY; REVIEW; STOMACH TUMOR; STOMACH ULCER; VIRULENCE;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; GASTRITIS; GENES, BACTERIAL; GENETIC MARKERS; HELICOBACTER PYLORI; HUMANS; PHENOTYPE; STOMACH NEOPLASMS; STOMACH ULCER; VIRULENCE;

EID: 0035406678     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Blaser MJ, Parsonnet J. Parasitism by the 'slow' bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 1994; 94: 4-8.
2. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Pérez-Pérez GI, et al. Prevalence of Helicobacter pylori infection and histologic gastritis in symptomatic persons. N Engl J Med 1989; 321: 1562-6.
3. Gisbert JP, Pajares JM. ¿Son todos los H. pylori malos? Rev Esp Enferm Dig 1999; 91: 508-15.
4. Go MF, Cissell L, Graham DY. Virulence and pathogenicity of Helicobacter pylori. Gastroenterol Clinics North Am 2000; 29: 649-70.
5. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993; 90: 5791-5.
6. Blaser MJ. Heterogeneity of Helicobacter pylori. Eur J Gastroenterol Hepatol 1997; 9 (Supl 1): S3-7.
7. Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, et al. Mucosal IgA recognition of Helicobacter pylori 120kDa protein, peptic ulceration, and gastric pathology. Lancet 1991; 338: 332-5.
8. Weel JF, van der Hulst RW, Gerrits Y, Roorda P, Feller M, Dankert J, et al. The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related disease. J Infect Dis 1996; 173: 1171-5.
9. Beales ILP, Crabtree JE, Scunes D, Covacci A, Calam J, et al. Antibodies to cagA protein are associated with gastric atrophy in Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1996; 8: 645-9.
10. Kuipers EJ, Pérez-Pérez GI, Meuwissen SG, Blaser MJ. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Center Inst 1995; 87: 1777-80.
11. Shimoyama T, Crabtree JE. Mucosal chemokines in Helicobacter pylori infection. J Physiol Pharmacol 1997; 48: 315-23.
12. Tummuru MKR, Cover TL, Blaser MJ. Mutation of the cytotoxin -associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori. Infect Immun 1994; 62: 2609-13.
13. Crabtree JE, Kersulyte D, Hernández V. Helicobacter pylori induction of IL-8 synthesis in gastric epithelial cells depends on genes throughout the cag pathogenicity island. Gut 1997; 40 (Supl 1): A69.
14. Atherton JC, Tham KT, Peek RM, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assesed by quantitative culture and histology. J Infect Dis 1996; 174: 552-6.
15. Crabtree JE, Wyatt JI, Trejdosiewicz LK, Peichl P, Nichols PH, Ramsay N, et al. Interleukin-8 expression in Helicobacter pylori infected normal and neplastic gastroduodenal mucosa. J Clin Pathol 1994; 47: 61-6.
16. Peek RM, Thompson SA, Atherton JC, Blaser MJ, Miller GG. Expression of a novel ulcer-associated Helicobacter pylori gene, iceA, following adherence to gastric epithelial cells [abstract]. Gastroenterology 1996; 110: A225.
17. Basso D, Navaglia F, Brigato L, Piva MG, Toma A, Greco E, et al. Analysis of Helicobacter pylori vacA and cagA genotypes and serum antibody profile in benign and malignant gastroduodenal diseases. Gut 1998; 43: 182-6.
18. Azuma T, Ito Y, Miyaji H, Dojyo M, Tanaka Y, Hirai M, et al. Host's genetic difference between Helicobacter pylori-positive and Helicobacter pylori-negative gastric carcinoma [abstract]. Gastroenterology 1995; 108: A50.
19. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 1995; 19 (Supl 1): S37-43.
20. Mitchell HM, Hazell SL, Li YY, Hu PJ. Serological response to specific Helicobacter pylori antigens: Antibody against cagA antigen is not predictive of gastric cancer in a developing country. Am J Gastroenterol 1996; 91: 1785-8.
21. Jenks PJ, Megraud F, Labigne A. Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island. Gut 1998; 43: 752-8.