The Functional ccpA Gene Is Required for Carbon Catabolite Repression in Lactobacillus plantarum

Applied and Environmental Microbiology

Volumn 67, Issue 7, 2001, Pages 2903-2907

  Muscariello, Lidia ^a   Marasco, Rosangela ^b   De Felice, Maurilio ^c   Sacco, Margherita ^a,d  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSITY OF SANNIO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CATABOLITE CONTROL PROTEIN, BACTERIA; DIPEPTIDASE; DNA BINDING PROTEIN; PROLINE DIPEPTIDASE; REPRESSOR PROTEIN;

ARTICLE; DNA FOOTPRINTING; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LACTOBACILLUS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

BACTERIAL PROTEINS; BASE SEQUENCE; DIPEPTIDASES; DNA FOOTPRINTING; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; LACTOBACILLUS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 0035404452     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.67.7.2903-2907.2001     Document Type: Article

References (36)

1. Bengmark, S. 2000. Colonic food: pre- and probiotics. Am. J. Gastroenterol. 95:5-7.
2. Brewer, A. C., P. J. March, and R. K. Patient. 1990. A simplified method for in vivo footprinting using DMS. Nucleic. Acids Res. 18:5574.
3. Chauvaux, S., I. T. Paulsen, and M. H. Saier, Jr. 1998. CcpB, a novel transcription factor implicated in catabolite repression in Bacillus subtilis. J. Bacteriol. 180:491-497.
4. Chen, J. D., and D. A. Morrison. 1988. Construction and properties of a new insertion vector, pJDC9, that is protected by transcriptional terminators and useful for cloning of DNA from Strepcoccus pneumoniae. Gene 64:155-164.
5. Deutscher, J., E. Küster, U. Bergstedt, V. Charrier, and W. Hillen. 1995. Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteria. Mol. Microbiol. 15: 1049-1053.
6. Egeter, O., and R. Brückner. 1996. Catabolite repression mediated by the catabolite control protein CcpA in Staphylococcus xylosus. Mol. Microbiol. 21:739-749.
7. Ferain, T., J. N. Hobbs, J. Richardson, N. Bernard, D. Garmyn, P. Hols, N. E. Allen, and J. Delcour. 1996. Knockout of the two ldh genes has a major impact on peptidoglycan precursor synthesis in Lactobacillus plantarum. J. Bacteriol. 178:5431-5437.
8. Geoffroy, M. C., C. Guyard, B. Quatannens, S. Pavan, M. Lange, and A. Mercenier. 2000. Use of green fluorescent protein to tag lactic acid bacterium strains under development as live vaccine vectors. Appl. Environ. Microbiol. 66:383-391.
9. Gösseringer, R., E. Küster, A. Galinier, J. Deutscher, and W. Hillen. 1997. Cooperative and non-cooperative DNA binding modes of catabolite control protein CcpA from Bacillus megaterium results from sensing two different signals. J. Mol. Biol. 266:665-676.
10. Henkin, T. M. 1996. The role of CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis. FEMS Microbiol. Lett. 135:9-15.
11. Henkin, T. M., F. J. Grundy, W. L. Nicholson, and G. H. Chambliss. 1991. Catabolite repression of α-amylase gene expression in Bacillus subtilis involves a trans-acting gene product homologous to the Escherichia coli lacI and galR repressors. Mol. Microbiol. 5:575-584.
12. Hueck, C. J., W. Hillen, and M. H. Saier, Jr. 1994. Analysis of a cis-active sequence mediating catabolite repression in Gram-positive bacteria. Res. Microbiol. 145:503-518.
13. Hueck, C. J., A. Kraus, D. Schmiedel, and W. Hillen. 1995. Cloning expression and functional analysis of the catabolite control protein CcpA from Bacillus megaterium. Mol. Microbiol. 16:855-864.
14. Kim, J., M. I. Voskuil, and G. H. Chambliss. 1998. NADP, corepressor for the Bacillus catabolite control protein CcpA. Proc. Natl. Acad. Sci. USA 95:9590-9595.
15. Küster E., T. Hilbich, M. K. Dahl, and W. Hillen. 1999. Mutations in catabolite control protein CcpA separating growth effects from catabolite repression. J. Bacteriol. 181:4125-4128.
16. Leboeuf, C., L. Leblanc, Y. Auffray, and A. Hartke. 2000. Characterization of the ccpA gene of Enterococcus faecalis: identification of starvation-inducible proteins regulated by CcpA. J. Bacteriol. 182:5799-5806.
17. Leer, R. J., H. Christiaens, W. Verstraete, L. Peters, M. Posno, and P. H. Pouwels. 1993. Gene disruption in Lactobacillus plantarum strain 80 by site-specific recombination: isolation of a mutant strain deficient in conjugated bile salt hydrolase activity. Mol. Gen. Genet. 239:269-272.
18. Leong-Morgenthaler, P., M. C. Zwahlen, and H. Hottinger. 1991. Lactose metabolism in Lactobacillus bulgaricus: analysis of the primary structure and expression of the genes involved. J. Bacteriol. 173:1951-1957.
19. Luesink, E., R. van Herpen, B. Grossiord, O. P. Kuipers, and W. de Vos. 1998. Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA. Mol. Microbiol. 30:789-798.
20. Mahr, K., W. Hillen, and F. Titgemeyer. 2000. Carbon catabolite repression in Lactobacillus pentosus: analysis of the ccpA region. Appl. Environ. Microbiol. 66:277-283.
21. Marasco, R., C. T. Lago, and M. De Felice. 1995. Utilization of cellobiose and other β-D-glucosides in Agrobacterium tumefaciens. Res. Microbiol. 146: 485-492.
22. Marasco, R., L. Muscariello, M. Varcamonti, M. De Felice, and M. Sacco. 1998. Expression of the bglH gene of Lactobacillus plantarum is controlled by carbon catabolite repression. J. Bacteriol. 180:3400-3404.
23. Marasco, R., I. Salatiello, M. De Felice, and M. Sacco. 2000. A physical and functional analysis of the newly identified bglGPT operon of Lactobacillus plantarum. FEMS Microbiol. Lett. 186:269-273.
24. Martin-Verstraete, I., J. Deutscher, and A. Galinier. 1999. Phosphorylation of HPr and Crh by HPrK, early steps in the catabolite repression signalling pathway for the Bacillus subtilis levanase operon. J. Bacteriol. 181:2966-2969.
25. Miller J. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
26. Miwa, Y., M. Saikawa, and Y. Fujita. 1994. Possible function and some properties of the CcpA protein of Bacillus subtilis. Microbiology 140:2567-2575.
27. Monedero, V., J. M. Gosalbes, and G. Perez-Martinez. 1997. Catabolite repression in Lactobacillus casei ATCC393 is mediated by CcpA. J. Bacteriol. 179:6657-6664.
28. Reizer, J., C. Hoischen, F. Titgemeyer, C. Rivolta, R. Rabus, J. Stülke, D. Karamata, M. H. Saier, Jr., and W. Hillen. 1998. A novel protein kinase that controls carbon catabolite repression in bacteria. Mol. Microbiol. 27:1157-1169.
29. Saier, M. H., Jr. 1996. Regulation of carbon metabolism in bacteria, a Forum in Microbiology. Res. Microbiol. 147:439-587.
30. Saier, M. H., Jr. 1998. Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol. Bioeng. 58:170-174.
31. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
32. Simpson, C. L., and R. R. Russel. 1998. Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans. Infect. Immun. 66: 2085-2092.
33. Turinsky, A. J., F. J. Grundy, J. Kim, G. H. Chamblis, and T. M. Henkin. 1998. Transcriptional activation of the Bacillus subtilis ackA gene requires sequences upstream of the promoter. J. Bacteriol. 180:5961-5967.
34. van den Bogaard, P., M. Kleerebezem, O. P. Kuipers, and W. M. de Vos. 2000. Control of lactose transport, β-galactosidase activity, and glycolysis by CcpA in Streptococcus thermophilus: evidence for carbon catabolite repression by a non-phosphoenolpyruvate-dependent phosphotransferase system sugar. J. Bacteriol. 182:5982-5989.
35. Wouters, J. A., H. H. Kamphuis, J. Hugenholts, O. P. Kuipers, W. M. de Vos, and T. Abee. 2000. Changes in glycolytic activity of Lactococcus lactis induced by low temperature. Appl. Environ. Microbiol. 66:3686-3691.
36. Zelieckas, J. M., L. V. Jr. Wray, and S. H. Fisher. 1998. Expression of the Bacillus subtilis acsA gene: position and sequence context affect cre-mediated carbon catabolite repression. J. Bacteriol. 180:6649-6654.