EC-SOD gene therapy reduces paracetamol-induced liver damage in mice

Journal of Gene Medicine

Volumn 3, Issue 4, 2001, Pages 321-325

  Laukkanen, Mikko O ^a   Leppanen, Pia ^a   Turunen, Paivi ^a   Tuomisto, Tiina ^a   Naarala, Jonne ^a   Yla Herttuala, Seppo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Apoptosis; Extracellular superoxide dismutase (EC SOD); Gene transfer; Inflammation; N acetyl p aminophenol (acetaminophen, APAP); Necrosis

Indexed keywords

ADENOVIRIDAE;

CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; PARACETAMOL; RECOMBINANT PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL; ANIMAL HEPATITIS; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE THERAPY; GENETICS; KINETICS; LIVER; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; TIME;

ACETAMINOPHEN; ANIMALS; CASPASE 3; CASPASES; GENE THERAPY; HEPATITIS, ANIMAL; KINETICS; LIVER; MICE; RECOMBINANT PROTEINS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 0035404419     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.194     Document Type: Article

References (22)

1. Wang P, Chen H, Qin H, et al. Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury. Proc Natl Acad Sci U S A 1998; 95: 4556-4560.
2. Church SL, Grant JW, Ridnour LA, et al. Increased manganese Superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci U S A 1993; 90: 3113-3117.
3. Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing Superoxide dismutase. Oncogene 1995; 10: 1989-2000.
4. Karlsson K, Sandström J, Edlund A, Marklund SL. Turnover of extracellular-superoxide dismutase in tissues. Lab Invest 1994; 70: 705-710.
5. Karlsson K, Sandström J, Edlund A, Edlund T, Marklund SL. Pharmacokinetics of extracellular-superoxide dismutase in the vascular system. Free Radic Biol Med 1993; 14: 185-190.
6. Huber W, Menander-Huber KB, Saifer MG, Williams LD. Bioavailability of Superoxide dismutase: implications for the anti-inflammatory action mechanism of orgotein. Agents Actions Suppl 1980; 7: 185-195.
7. Li Q, Bolli R, Qiu Y, Tang XL, Murphree SS, French BA. Gene therapy with extracellular Superoxide dismutase attenuates myocardial stunning in conscious rabbits. Circulation 1998; 98: 1438-1448.
8. Carlsson LM, Jonsson J, Edlund T, Marklund SL. Mice lacking extracellular Superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci USA 1995; 92: 6264-6268.
9. Folz RJ, Abushamaa AM, Suliman HB. Extracellular Superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J Clin Invest 1999; 103: 1055-1066.
10. Oury TD, Piantadosi CA, Crapo JD. Cold-induced brain edema in mice. Involvement of extracellular Superoxide dismutase and nitric oxide. J Biol Chem 1993; 268: 15394-15398.
11. Yavuz Y, Yuksel M, Yegen BC, Alican I. The effect of antioxidant therapy on colonic inflammation in the rat. Res Exp Med (Berl) 1999; 199: 101-110.
12. Salvemini D, Wang ZQ, Zweier JL, et al. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats (see Comments). Science 1999; 286: 304-306.
13. Clark R, Borirakchanyavat V, Davidson AR, et al. Hepatic damage and death from overdose of paracetamol. Lancet 1973; 1: 66-70.
14. Ray SD, Sorge CL, Tavacoli A, Raucy JL, Corcoran GB. Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo early after hepatotoxic acetaminophen overdose in mice. Adv Exp Med Biol 1991; 283: 699-705.
15. Kourounakis AP, Rekka EA, Kourounakis PN. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol 1997; 49: 938-942.
16. Esterline RL, Ray SD, Ji S. Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Biochem Pharmacol 1989; 38: 2387-2390.
17. Boulares HA, Giardina C, Navarro CL, Khairallah EA, Cohen SD. Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity. Toxicol Sci 1999; 48: 264-274.
18. McLean AE, Nutiall L. An in vitro model of liver injury using paracetamol treatment of liver slices and prevention of injury by some antioxidants. Biochem Pharmacol 1978; 27: 425-430.
19. Laitinen M, Pakkanen T, Donetti E, et al. Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum Gene Ther 1997; 8: 1645-1650.
20. Laukkanen MO, Lehtolainen P, Turunen P, et al. Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation (in process citation). Gene 2000; 254: 173-179.
21. Marklund S. Spectrophotometric study of spontaneous disproportionation of Superoxide anion radical and sensitive direct assay for superoxide dismutase. J Biol Chem 1976; 251: 7504-7507.
22. Karlsson K, Marklund SL. Heparin-induced release of extra-cellular Superoxide dismutase to human blood plasma. Biochem J 1987; 242: 55-59.