Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1α,25-dihydroxyvitamin D3

Steroids

Volumn 66, Issue 7, 2001, Pages 539-548

  Blæhr, Lars K A ^a   Björkling, Fredrik ^a   Binderup, Ernst ^a   Calverley, Martin J ^a   Kaastrup, Peter ^b  

^a LEO PHARMA A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

1 ,25 Dihydroxyvitamin D3 analog; Antibody production; EB1089; Enzyme immunoassay; Hapten; Synthesis

Indexed keywords

DRUG METABOLITE; HAPTEN; POLYCLONAL ANTIBODY; SEOCALCITOL; VITAMIN D DERIVATIVE;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CROSS REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME IMMUNOASSAY; HUMAN; SERUM;

ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTINEOPLASTIC AGENTS; CALCITRIOL; CROSS REACTIONS; HAPTENS; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 0035400906     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00225-7     Document Type: Article

References (15)

1. Seocalcitol (EB 1089); a vitamin D analog of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation
2. Rapid chromatographic technique for preparative separations with moderate resolution
3. Synthesis of hydrindan derivatives related to vitamin D
4. 3; design, synthesis, and preliminary biologic evaluation
5. A convenient synthesis of dicarboxylic monoesters using isopropenyl esters; synthesis of oxaunomycin derivatives
6. Production of a group-specific antibody to 1α,25-dihydroxyvitamin D and its derivatives having the 1α,3β-dihydroxylated A-ring structure
7. 3 in serum
8. Antibody avidity determination by ELISA using thiocyanate elution
9. Antibody avidity in Yorkshire pigs of high and low immune response groups
10. The assessment of antibody affinity distribution by thiocyanate elution; a simple dose-response approach
11. Metabolism of the vitamin D analog EB1089; identification of in vivo and in vitro liver metabolites and their biologic activities
12. Determination of the vitamin D analog EB 1089 (seocalcitol) in human and pig serum by liquid chromatography tandem mass spectrometry
13. 3-BSA conjugant linked through the C-11α or C-3 position
14. Production and specificity of anti-22-oxacalcitriol antisera