No influence of acute hypertriglyceridemia on plasma t-PA in healthy male volunteers

Thrombosis Research

Volumn 103, Issue 1, 2001, Pages 9-16

  Kemme, Michiel J B ^a   Burggraaf, Jacobus ^a   Schoemaker, Rik C ^a   Cohen, Adam F ^a  

^a CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

Author keywords

Clearance; Intralipid; Liver blood flow; Plasminogen activator inhibitor; Sorbitol; Tissue type plasminogen activator

Indexed keywords

ALTEPLASE; ANTIGEN; INTRALIPID; LIPID EMULSION; PLASMINOGEN ACTIVATOR INHIBITOR 1; SODIUM CHLORIDE; SORBITOL; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME METABOLISM; HUMAN; HUMAN EXPERIMENT; HYPERTRIGLYCERIDEMIA; INFUSION; LIVER BLOOD FLOW; MALE; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; TIME; TREATMENT OUTCOME; VOLUNTEER;

ACUTE DISEASE; ADULT; CROSS-OVER STUDIES; FAT EMULSIONS, INTRAVENOUS; HUMANS; HYPERTRIGLYCERIDEMIA; LIVER CIRCULATION; MALE; METABOLIC CLEARANCE RATE; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0035398532     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(01)00270-5     Document Type: Article

References (29)

1. Hypertriglyceridemia, but not hypercholesterolemia, is associated with the alterations of fibrinolytic system
2. Plasma tissue plasminogen activator inhibitor levels in coronary artery disease: Correlation with age and serum triglyceride concentrations
3. The influence of high fat diet on the fibrinolytic activity
4. Effect of modified dairy fat on fasting and postprandial haemostatic variables in healthy young men
5. Impaired fibrinolytic activity induced by ingestion of butter: Effect of increased plasma lipids on the fibrinolytic activity
6. Increased PAI activity and PAI-1 antigen occurring with an oral fat load: Associations with PAI-1 genotype and plasma active TGF-beta levels
7. Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator
8. Chylomicron triglyceride clearance: Comparison of three assessment methods
9. Studies on the fat emulsion intralipid: I. Association of serum proteins to intralipid triglyceride particles (ITP)
10. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: A mechanism for arterial thrombosis and myocardial infarction
11. Low-dose infusion of recombinant tissue-type plasminogen activator in healthy volunteers to investigate the biodistribution of t-PA in the early phase of infusion
12. The influence of reduced liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue factor pathway inhibitor
13. Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow
14. Daytime fluctuations in blood of tissue-type plasminogen activator (t-PA) and its fast-acting inhibitor (PAI-1)
15. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase
16. Clearance receptors for tissue-type plasminogen activator
17. Inhibition of mannose receptor-mediated clearance of tissue-type plasminogen activator (t-PA) by dextran: A new explanation for its antithrombotic effect
18. In vitro reciprocal exchange of apoproteins and nonpolar lipids between human high density lipoproteins and an artificial triglyceride-phospholipid emulsion (Intralipid)
19. Receptor and non-receptor mediated uptake of chylomicron remnants by the liver
20. Postprandial effects of an oleic acid-rich oil compared with butter on clotting factor VII and fibrinolysis in healthy men
21. Duplex ultrasound measurement of postprandial intestinal blood flow: Effect of meal composition
22. Modifications in hepatic blood flow and portal pressure produced by different diets
23. The hepatic circulation
24. Short term ACE inhibition may influence exercise-induced changes in haemostasis in healthy subjects
25. Plasminogen activator inhibitor in plasma: Risk factor for recurrent myocardial infarction
26. Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
27. Effect of a single high-fat meal on endothelial function in healthy subjects
28. TI-Acetylcholine-mediated vasodilatation and tissue-type plasminogen activator release in normal and hypertensive men
29. Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: Reversal after lipid-lowering therapy by atorvastatin