Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron: A computer model

Neurocomputing

Volumn 38-40, Issue , 2001, Pages 223-229

  Gradwohl, G ^a,b   Grossman, Y ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NEGEV ACADEMIC COLLEGE OF ENGINEERING   (Israel)

Author keywords

motoneuron; Computer simulation; Dendritic voltage dependent channels

Indexed keywords

CELLS; COMPUTER SIMULATION; ELECTRIC POTENTIAL; MORPHOLOGY; PHYSIOLOGY;

NEURON SIMULATORS;

NEUROLOGY;

ALPHA NERVE FIBER; ARTICLE; CELL STRUCTURE; CHANNEL GATING; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; DENDRITE; ELECTRIC POTENTIAL; EXCITATORY POSTSYNAPTIC POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CONDUCTION; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; SPINAL CORD MOTONEURON;

EID: 0035383923     PISSN: 09252312     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-2312(01)00521-5     Document Type: Article

References (18)

1. B.-X. Gao, L. Ziskind-Conhaim, Development of glycine- and GABA- gated currents in rat spinal motoneurons, J Neurophysiol. 74 (1995) 113-121.
2. S. Cullheim, J.W. Fleshman, L.L. Glenn, R.E. Burke, Three-dimensional architecture of dendritic trees in type-identified alpha-motoneurons, J. Comp. Neurol. 255 (1987) 82-96.
3. J.W. Fleshman, I. Segev, R.E. Burke, Electronic architecture of type-identified α-motoneurons in cat spinal cord, J. Neurophysiol. 60 (1988) 60-85.
4. G. Gradwohl, R. Nitzan, Y. Grossman, Homogeneous distribution of excitatory and inhibitory synapses on the dendrites of cat surea triceps α-motoneurons increases synaptic efficacy: computer model, Neurocomputing 26-27 (1999) 155-162.
5. M. Hines, A program for simulation of nerve equations with branching geometries, Int. J. Biomed. Comput. 24 (1989) 55-68.
6. W.R. Holmes, W.B. Levy, Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes, J. Neurophysiol. 63 (1990) 1148-1168.
7. E. Jankowska, W.J. Roberts, Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones, J. Physiol. (Lond.) 222 (1972) 623-642.
8. M.E. Larkum, T. Launey, A. Dityatev, H.R. Luscher, Integration of excitatory postsynaptic potentials in dendrites of motoneurons of rat spinal cord slice cultures, J. Neurophysiol. 2 (1998) 924-935.
9. H.R. Luscher, M.E. Larkum, Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons, J. Neurophysiol. 80 (1998) 715-729.
10. L.E. Moore, J.T. Buchanan, C.R. Murphey, Localization and interaction of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of lamprey spinal neurons, Biophys. J. 68 (1) (1995) 96-103.
11. M. Pinco, A. Lev-Tov, Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in isolated spinal cord of neonatal rats, J. Neurophysiol. 72 (1994) 2406-2419.
12. M. Rapp, Y. Yarom, I. Segev, Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells, Proc. Natl. Acad. Sci. USA 93 (21) (1996) 11985-11990.
13. S. Redman, B. Walmsley, Amplitude fluctuations in synaptic potentials evoked in cat spinal motoneurones at identified group Ia synapses, J. Physiol. (Lond.) 343 (1983) 135-145.
14. J.S. Riddell, E. Jankowska, J. Huber, Organization of neuronal systems mediating presynaptic inhibition of group II muscle afferents in the cat, J. Physiol. (Lond.) 483 (1995) 443-460.
15. I. Segev, J.W. Fleshman Jr., R.E. Burke, Computer simulation of group Ia EPSPs using morphologically realistic models of cat alpha-motoneurons, J. Neurophysiol. 64 (2) (1990) 648-660.
16. G.J. Stuart, S.J. Redman, Voltage dependence of Ia reciprocal inhibitory currents in cat spinal motoneurones, J. Physiol. (Lond.) 420 (1990) 111-125.
17. G.L. Stuart, B. Sakmann, Active propagation of somatic action potentials into neocortical pyramidal cell dendrites, Nature 367 (1994) 69-72.
18. H.G. Traven, L. Brodin, A. Lansner, O. Ekeberg, P. Wallen, S. Grillner, Computer simulations of NMDA and non-NMDA receptor-mediated synaptic drive: sensory and supraspinal modulation of neurons and small networks, J. Neurophysiol. 70 (1993) 695-709.