Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons

Journal of Neurophysiology

Volumn 80, Issue 2, 1998, Pages 715-729

  Lüscher, Hans R ^a   Larkum, Matthew E ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ANTIDROMIC STIMULATION; ARTICLE; ATTENUATION; BRAIN SLICE; DENDRITE; MOTONEURON; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SPIKE; SPINAL CORD MOTONEURON;

EID: 0031810928     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.2.715     Document Type: Article

References (44)

1. ARAKI, T. AND OTANI, T. Response of single motoneurons to direct stimulation in toad's spinal cord. J. Neurophysiol. 18: 472-485, 1955.
2. ARAKI, T. AND TERZUOLO, C. A. Membrane currents in spinal motoneurons associated with the action potential and synaptic activity. J. Neurophysiol. 25: 772-789, 1962.
3. BROCK, L. G., COOMBS, J. S., AND ECCLES, J. C. Intracellular recording from antidromically activated motoneurones. J. Physiol. (Lond.) 122: 429-461, 1953.
4. + channel densities in the soma and axon initial segment of subicular pyramidal neurons. J. Neurosci. 16: 6676-6686, 1996.
5. COOLEY, J. W. AND DODGE, F. A. Digital computer simulations for excitation and propagation of the nerve impulse. Biophys. J. 6: 583-599, 1966.
6. COOMBS, J. S., CURTIS, D. R., AND ECCLES, J. C. The generation of impulses in motoneurones. J. Physiol. (Lond.) 139: 232-249, 1957.
7. DODGE, F. A. AND COOLEY, J. W. Action potential in the motoneuron. IBM J. Res. Dev. 17: 219-229, 1973.
8. ECCLES, J. C., LIBET, B., AND YOUNG, R. R. The behaviour of chromatolyzed motoneurones studied by intracellular recording. J. Physiol. (Lond.) 143: 11-40, 1985.
9. FATT, P. Electric potentials occurring around a neurone during antidromic activation. J. Neurophysiol. 20: 27-60, 1975.
10. FUORTES, M.G.F., FRANK, K., AND BECKER, M. C. Steps in the production of motoneuron spikes. J. Gen. Physiol. 40: 735-752, 1957.
11. GOGON, P., GUERITAUD, J. P., AND TYC-DYMONT, S. Comparison of antidromic and orthodromic action potentials of identified motor axons in the cat's brain stem. J. Physiol. (Lond.) 335: 205-220, 1983.
12. GOLDSTEIN, S. S. AND RALL, W. Changes of action potential shape and velocity for changing core conductor geometry. Biophys. J. 14: 731-757, 1974.
13. HÄUSSER, M., STUART, G., RACCA, C., AND SAKMANN, B. Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 15: 637-647, 1995.
14. MINES, M. NEURON-a program for simulation of nerve equations. In: Neural Systems: Analysis and Modeling, edited by F. Eckman. Norwell, MA: Kluwer Academic Publishers, 1993, p. 127-136.
15. HODGKIN, A. F. AND HUXLEY, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117: 500-544, 1952.
16. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387: 869-875, 1997.
17. HUGUENARD, J. R., HAMILL, O. P., AND PRINCE, D. A. Sodium channels in dendrites of rat cortical pyramidal neurons. Proc. Natl. Acad. Sci. USA 86: 2473-2477, 1989.
18. JACK, J.J.B., NOBLE, D., AND TSIEN, R. W. Electrical Current Flow in Excitable Cells. Oxford, UK: Clarendon, 1975.
19. KUNO, M. AND LLINÀS, R. Enhancement of synaptic transmission by dendritic potentials in chromatolyzed motoneurones of the cat. J. Physiol. (Lond.) 210: 807-821, 1970.
20. LARKUM, M. E., RIOULT, M. G., AND LÜSCHER, H.-R. Propagation of action potentials in the dendrites of neurons from rat spinal cord slice cultures. J. Neurophysiol. 75: 154-169, 1996.
21. LÜSCHER, H.-R. AND SHINER, J. S. Computation of action potential propagation and bouton activation in terminal arborizations of different geometry. Biophys. J. 58: 1377-1388, 1990a.
22. LÜSCHER, H.-R. AND SHINER, J. S. Simulation of action potential propagation in complex arborizations. Biophys. J. 58: 1389-1399, 1990b.
23. LÜSCHER, C., STREIT, J., LIPP, P., AND LÜSCHER, H.-R. Action potential propagation through embryonic dorsal root ganglion cells in culture. II. Decrease of conduction reliability during repetitive stimulation. J. Neurophysiol. 72: 634-643, 1994.
24. 2+ influx into the dendrites of hippocampal pyramidal neurons. J. Neurophysiol. 74: 1335-1342, 1995.
25. MAGEE, J. C. AND JOHNSTON, D. A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science 275: 209-213, 1997.
26. MAINEN, Z. F., JOERGES, J., HUGUENARD, J. R., AND SEJNOWSKI, T. J. A model of spike initiation in neocortical pyramidal neurons. Neuron 15: 1427-1439, 1995.
27. MARKRAM, H., HELM, P. J., AND SAKMANN, B. Dendritic calcium transients evoked by single back-propagating action potentials in neocortical pyramidal neurons. J. Physiol. (Lond.) 485: 1-20, 1995.
28. MARKRAM, H., LüBKE, J., FROTSCHER, M., AND SAKMANN, B. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275: 213-215, 1997.
29. MOORE, J. W., STOCKBRIDGE, N., AND WESTERFIELD, M. On the site of impulse generation in a neuron. J. Physiol. (Lond.) 336: 301-311, 1983.
30. PALAY, S. L., SOTELO, C., PETERS, A., AND ORKLAND, P. M. The axon hillock and the initial segment. J. Cell Biol. 38: 193-201, 1968.
31. PETERS, A., PROSKAUER, C. C., AND KAISERMAN-ABRAMOF, I. R. The small pyramidal neuron of the rat cerebral cortex: the axon hillock and the initial segment. J. Cell Biol. 39: 604-619, 1968.
32. RALL, W. Theoretical significance of dendritic tree for input-output relation. In: Neural Theory and Modeling, edited by R. F. Reiss. Stanford, CA: Stanford University Press, 1964, p. 73-97.
33. RAPP, M., YAROM, Y., AND SEGEV, I. Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells. Proc. Natl. Acad. Sci. USA 93: 11985-11990, 1996.
34. REGEHR, W., KEHOE, J., ASCHER, P., AND ARMSTRONG, C. Synaptically triggered action potentials in dendrites. Neuron 11: 145-151, 1993.
35. SCHILLER, J., SCHILLER, Y., AND SAKMANN, B. Calcium action potentials in apical dendrites of neocortical pyramidal neurons in rat brain slices. Soc. Neurosci. Abstr. 22: 316.5, 1996.
36. SPRUSTON, N., SCHILLER, Y., STUART, G., AND SAKMANN, B. Activity dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268: 297-300, 1995.
37. STUART, G. J. AND SAKMANN, B. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367: 69-72, 1994.
38. STUART, G. J. AND SAKMANN, B. Action potential initiation in neocortical pyramidal neurons-revisited. Soc. Neurosci. Abstr. 22: 316.6, 1996.
39. STUART, G., SCHILLER, J., AND SAKMANN, B. Action potential initiation and propagation in rat neocortical pyramidal neurons. J. Physiol. (Lond.) 505: 617-632, 1997.
40. TERZUOLO, C. A. AND ARAKI, T. An analysis of intra-versus extracellular potential changes associated with activity of single spinal motoneurons. Ann. NY Acad. Sci. 94: 547-558, 1961.
41. TRAUB, R. D. AND LLINÀS, R. The spatial distribution of ionic conductances in normal and axotomized motoneurones. Neuroscience 2: 829-849, 1977.
42. ULRICH, D., QUADRONI, R., AND LÜSCHER, H.-R. Electrotonic structure of motoneurons in spinal cord slice cultures: a comparison of compartmental and equivalent cylinder models. J. Neurophysiol. 72: 861-871, 1994.
43. VIANA, F., BAYLISS, D. A., AND BERGER, A. J. Multiple potassium conductances and their role in action potential repolarization and repetitive firing behavior of neonatal rat hypoglossal motoneurons. J. Neurophysiol. 69: 2150-2163, 1993.
44. 2+ accumulations in dendrites of neocortical pyramidal neurons: an apical band and evidence for two functional compartments. Neuron 13: 23-43, 1994.