Clinical, pathological and immunological aspects of periodontal disease

Acta Odontologica Scandinavica

Volumn 59, Issue 3, 2001, Pages 154-160

  Kinane, Denis F ^a   Lappin, David F ^a  

^a GLASGOW DENTAL HOSPITAL AND SCHOOL   (United Kingdom)

Author keywords

Cell proliferation; Cell synthesis; Cellular immunity; Chronic periodontitis; Humoral immunity; Plasma cells

Indexed keywords

BACTERIUM ANTIBODY; CYTOKINE; IMMUNOGLOBULIN;

ANTIBODY PRODUCTION; BACTERIUM; CELL DIVISION; CELL MOTION; CELLULAR IMMUNITY; DISEASE COURSE; DISEASE PREDISPOSITION; HUMAN; IMMUNOLOGY; MICROBIOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PERIODONTITIS; PLASMA CELL; REVIEW; TOOTH PLAQUE;

ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; BACTERIA; CELL DIVISION; CELL MOVEMENT; CYTOKINES; DENTAL PLAQUE; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULINS; PERIODONTITIS; PLASMA CELLS;

EID: 0035376141     PISSN: 00016357     EISSN: None     Source Type: Journal    
DOI: 10.1080/000163501750266747     Document Type: Article

References (47)

1. Takahashi K, Lappin D, Kinane DF. In situ localisation of cell synthesis and proliferation in periodontitis gingiva and tonsillar tissue Oral Dis 1996;2:210-6.
2. Koulouri O, Lappin DF, Radvar M, Kinane DF. Cell division, synthetic capacity and apoptosis in periodontal lesions analysed by in situ hybridisation and immunohistochemistry. J Clin Periodontol 1999;26:552-9.
3. Kinane DF, Adonogianaki E, Moughal N, Mooney J, Thornhill M. Immunocytochemical characterisation of cellular infiltrate, related endothelial changes and determination of GCF acute phase proteins during human experimental gingivitis. J Periodont Res 1991;26:286-8.
4. Kinane DF, Lappin DF, Koulouri O, Buckley A. Humoral immune responses in periodontal disease may have mucosal and systemic immune features. Clin Exp Immunol 1999;115:534-41.
5. Nagai A, Takahashi K, Sato N. Abnormal proportion of γδ T cells in peripheral blood is frequently detected in patients with periodontal disease. J Periodontol 1993; 64:963-7.
6. Gemmell E, Seymour GJ. Cytokine profiles of cells extracted from humans with periodontal diseases. J Dent Res 1993;77:16-26.
7. Kinane DF, Goudie RB, Karim SN, Garioch JJ, Moughal NA, Al Badri A. Heterogeneity and selective localisation of T cell clones in human skin and gingival mucosa. J Periodont Res 1993;29:497-9.
8. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 1976; 33:235-49.
9. Alison M, Chaudry Z, Baker J, Lauder I, Pringle H. Liver regeneration: a comparison of in situ hybridization for histone mRNA with bromodeoxyuridine labelling for the detection of S-phase cells. J Histochem Cytochem 1994;42:1603-8.
10. Sawhney N, Hall PA. Ki-67 structure, function and new antibodies. J Pathol 1992;168:161-2.
11. Bacchi CE, Gown AM. Detection of cell proliferation in tissue sections. Brazilian J Med Biol Res 1993;26:677-87.
12. Hall PA, Coates PJ. Assessment of cell proliferation in pathology - what next? Histopathology 1995;26:105-12.
13. Baker JJ, Tondreau SP. The stimulation of human peripheral blood lymphocytes by oral bacteria: macrophage and T-cell dependence. J Dent Res 1985;64:906-12.
14. Okada H, Kida T, Yamagami H. Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. Infect Immun 1983;41:365-74.
15. Ito H, Harada Y, Matsuo T. Possible role of T cells in the establishment of IgG plasma cell-rich periodontal lesion -augmentation of IgG synthesis in the polyclonal B cell activation response by autoreactive T cells. J Periodont Res 1988;23:39-45.
16. Meng HX, Zheng LF. T cells and T-cell subsets in periodontal diseases. J Periodont Res 1989;24:121-6.
17. Reinhardt RA, Bolton RW, McDonald TL. In situ lymphocyte subpopulations from active versus stable periodontal sites. J Periodontol 1988;59:656-70.
18. Johannssen AC, Nilsen R, Knudsen GE, Kristoffersen T. In situ characterisation of mononuclear cells in human chronic marginal periodontitis using monoclonal antibodies. J Periodont Res 1986; 21:113-27.
19. Reinhardt RA, McDonald TL, Bolton RW. In situ activated T lymphocytes in active versus stable periodontal lesions. J Periodont Res 1988;23:295-302.
20. Seymour GJ, Greenspan JS. The phenotypic characterisation of lymphocyte subpopulations in established human periodontal disease. J Periodont Res 1979;14:39-46.
21. Mackler BF, Waldrop TC, Schur P. IgG subclasses in human periodontal disease. I. Distribution and incidence of IgG subclasses bearing lymphocytes and plasma cells. J Periodont Res 1978;13:109-19.
22. Okada H, Ito H, Harada Y. T-cell requirement for establishment of the IgG-dominant B-cell lesion in periodontitis. J Periodont Res 1987;22:187-9.
23. Pringle JH, Primrose L, Kind CH, Talbot LC, Lauder I. In situ hybridization demonstration of poly-adenylated RNA sequences in formalin-fixed paraffin sections using a biotinylated oligonucleotide poly d(T) probe. J Pathol 1989;158:279-86.
24. Danks JA, McHale JC, Clark SP. In situ hybridization of parathyroid hormone-related protein in normal skin, skin tumors, and gynecological cancers using digoxigenin-labeled probes and antibody enhancement. J Histochem Cytochem 1995;43:510.
25. Lappin DF, Koulouri O, Radvar M, Hodge P, Kinane DF. Relative proportions of mononuclear cell types in periodontal lesions analysed by in situ hybridisation and immunohistochemistry. J Periodont Res 1999;26:183-9.
26. Sugawara M, Yamashita K, Yoshie H, Hara K. Detection of, and anti-collagen antibody produced by, CD5-positive B cells in inflamed gingival tissues. J Periodont Res 1992;27:489-98.
27. Yamazaki K, Nakajima T, Aoyagi T, Hara K. Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodont Res 1993;28:324-34.
28. Abe M, Tominaga K, Wakasa H. Phenotypic characterisation of human B-lymphocyte subpopulations, particularly human CD5+ B-lymphocyte subpopulation within the mantle zones of secondary follicles. Leukaemia 1994;8:1039-44.
29. Longhurst P, Gillett R, Johnson NW. Electron microscope quantitation of inflammatory infiltrates in childhood gingivitis. J Periodont Res 1980;15:255-66.
30. Schroeder HE, Münzel-Pedrazzoli S. Correlated morphometric and biochemical analysis of gingival tissue in early chronic gingivitis in man. Arch Oral Biol 1973; 18:899-923.
31. Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000;85:9-18.
32. MacDonald TT: Effector and regulatory lymphoid cells and cytokines in mucosal sites. Curr Top Microbiol Immunol 1999; 236:113-35.
33. Aoyagi T, Sugawara-Aoyagi M, Yamazaki K, Hara K. Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titres to Porphyromonas gingivalis. Oral Microbiol Immunol 1995;10:304-10.
34. Manhart SS, Reinhardt RA, Payne JB, Seymour GJ, Gemmell E, Dyer JK, et al. Gingival cell IL-2 and Il-4 in early onset periodontitis. J Periodontol 1994;144:662-6.
35. Yamazaki K, Nakajima T, Kubota Y, Gemmell E, Seymour GJ, Hara K. Cytokine messenger RNA expression in chronic inflammatory periodontal disease. Oral Microbiol Immunol 1997;12:281-7.
36. Sigusch B, Klinger G, Glockmann E, Simon HU. Production by actuated T lymphocytes. Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes. J Periodontol 1998;10:1098-104.
37. Gemmell E, Seymour GJ. γδ T lymphocytes in human periodontal disease tissue. J Periodontol 1995;66:780-5.
38. Lappin DF, Macleod C, Kerr A, Mitchell T, Kinane DF. Antiinflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clin Exp Immunol 2001;123: 294-300.
39. Salvi GE, Brown CE, Fujihashi K, et al. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res 1998;33:212-25.
40. Pilon M, Williams-Miller C, Cox DS. Interleukin-2-levels in gingival crevicular fluid in periodontitis. J Dent Res 1991;70:550.
41. Fujihashi K, Beagley KW, Kono Y. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993;142:1239-50.
42. Lundqvist C, Baranov V, Teglund S. Cytokine profile and ultrastructure of intraepithelial γδ T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J Immunol 1994;153:2302-12.
43. Seymour GJ, Cole KL, Powell RN. Interleukin-2 production and bone resorption activity by unstimulated lymphocytes extracted from chronically inflamed human periodontal tissues Arch Oral Biol 1985;30:481-4.
44. Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol 1995;99:384-91.
45. Roberts FA, McCaffery KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res 1997;76:1833-9.
46. Kinane D, Takahashi K, Mooney J. Crevicular fluid and serum IgG subclasses and corresponding mRNA expressing plasma cells in periodontal lesions. J Periodont Res 1997;2:176-8.
47. Takahashi K, Mooney J, Frandsen EVG, Kinane DF. IgG and IgA subclass mRNA bearing plasma cells in periodontitis gingiva and their protein levels in the gingival crevicular fluid. Clin Exp Immunol 1996;107:158-65.