Glucose production during exercise in humans: a-hv Balance and isotopic- tracer measurements compared

Journal of Applied Physiology

Volumn 87, Issue 1, 1999, Pages 111-115

  Bergeron, R ^a   Kjaer, M ^b   Simonsen, L ^b   Bulow J ^b   Galbo, H ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b BISPEBJERG HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Arteriohepatic venous balance; Glucose appearance; Indocyanine green; Splanchnic blood flow; 3H glucose

Indexed keywords

ADULT; ARTICLE; CONTINUOUS INFUSION; EXERCISE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEPATIC VEIN; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PORTAL VEIN BLOOD; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW; VEIN CATHETERIZATION;

EID: 0032789334     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.1.111     Document Type: Article

References (22)

1. Ahlborg, G., P. Felig, L. Hagenfeldt, R. Hendler, and J. Wahren. Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J. Clin. Invest. 53: 1080-1090, 1974.
2. Argoud, G. M., D. S. Schade, and R. P. Eaton. Underestimation of hepatic glucose production by radioactive and stable tracers. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E606-E615, 1987.
3. Cobelli, C., A. Mari, and E. Ferrannini. Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E679-E689, 1987.
4. Coggan, A. R. Plasma glucose metabolism during exercise in humans. Sports Med. 11: 102-124, 1991.
5. Ferrannini, E., L. D. Karz, M. G. Glickman, and R. A. Defronzo. Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man. Clin. Physiol. 10: 527-538, 1990.
6. Finegood, D. T., R. N. Bergman, and M. Vranic. Modeling error and apparent isotope discrimination counfound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37: 1025-1034, 1988.
7. Hetenyi, G., and K. H. Norwich. Validity of the rates of production and utilization of metabolites as determined by tracer methods in intact animals. Federation Proc. 33: 1841-1848, 1974.
8. Kjaer, M., H. Secher, F. W. Bach, and H. Galbo. Role of motor center activity for hormonal changes and substrate mobilization in humans. Am. J. Physiol. 253 (Regulatory Integrating Comp. Physiol. 22): R687-R695, 1987.
9. Mari, A., and A. D. Cherrington. Methods for the assessment of hepatic glucose production in vivo. In: The Role of the Liver in Maintaining Glucose Homeostasis, edited by M. J. Pagliassotti, S. N. Davis, and A. D. Cherrington. Nashville, TN: Landes, 1994, p. 1-18.
10. Ott, P. Hepatic elimination of indocyanine green with special reference to distribution kinetics and the influence of plasma protein binding. Pharmacol. Toxicol. 83, Suppl. II: 1-48, 1998.
11. Ott, P., S. Keiding, and L. Bass. Hepatic removal of two fractions of indocyanine green after a bolus injection in anesthetized pigs. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G1108-G1122, 1994.
12. Ott, P., S. Keiding, and L. Bass. The kinetics of continously infused indocyanine green in pigs. J. Pharmacokinet. Biopharm. 24: 19-44, 1996.
13. Radziuk, J. Experimental validation of measurements of glucose turnover in non-steady state. Am. J. Physiol. 234 (Endocrinol. Metab. Gastrointest. Physiol. 3): E84-E93, 1978.
14. Rowell, L. B., J. R. Blackmon, and R. A. Bruce. Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man. J. Clin. Invest. 43: 1677-1691, 1964.
15. Siegel, S., and J. H. Castellan, Jr. Non-Parametric Statistics for the Behavioral Sciences (2nd ed.). New York: McGraw-Hill, 1988.
16. Skak, C., and S. Keiding. Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man. Liver 7: 155-162, 1987.
17. Sonne, B. A model used to study exercise responses in the rat. With special reference to the regulation of carbohydrate metabolism. Acta Physiol. Scand. Suppl. 580: 1-77, 1989.
18. Steele, R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. NY Acad. Sci. 82: 420-430, 1959.
19. Stumvoll, M., C. Meyer, A. Mitrakou, V. Nadkarni, and J. E. Gerich. Renal glucose production and utilization: new aspects in humans. Diabetologia 40: 749-757, 1997.
20. Wahren, J., P. Felig, G. Ahlborg, and L. Jorfeldt. Glucose metabolism during leg exercise in man. J. Clin. Invest. 50: 2715-2725, 1971.
21. Wasserman, D. H., D. B. Lacy, D. R. Green, P. E. Williams, and A. D. Cherrington. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J. Appl. Physiol. 63: 2411-2417, 1987.
22. Winkler, K., J. A. Larsen, and T. Munkner. Determination of the hepatic blood flow in man by simultaneous use of five test substances measured in two parts of the liver. Scand. J. Clin. Lab. Invest. 17: 423-432, 1965.