Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats

Drug and Alcohol Dependence

Volumn 63, Issue 1, 2001, Pages 39-49

  Gerak, Lisa R ^a   Woolverton, William L ^b   Nader, Michael A ^c   Patrick, Graham A ^d   Harris, Louis S ^d   Winger, Gail ^e   Woods, James H ^e   France, Charles P ^a,f  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

^f Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Drug discrimination; Flunitrazepam; Pentobarbital dependent rats; Rhesus monkey; Self administration

Indexed keywords

DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; METHOHEXITAL; PENTOBARBITAL; TRIAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BODY WEIGHT; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; DRUG EFFECT; FEMALE; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY; WITHDRAWAL SYNDROME;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; DISCRIMINATION LEARNING; FEMALE; FLUNITRAZEPAM; GABA MODULATORS; MACACA MULATTA; MALE; PENTOBARBITAL; REINFORCEMENT (PSYCHOLOGY); SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

MACACA MULATTA;

EID: 0035372507     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(00)00189-7     Document Type: Article

References (36)

1. Zipeprol: preclinical assessment of abuse potential
2. Drug abuse potential evaluation in animals
3. Benzodiazepines and other psychotropic drugs abused by patients in a methadone maintenance program: familiarity and preference
4. Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidence by disruptions in schedule-controlled behavior
5. Clinical pharmacokinetics of non-opiate abused drugs
6. Withdrawal reaction after long-term therapeutic use of benzodiazepines
7. Benzodiazepine use among injecting heroin users
8. Self-administration of psychoactive substances by the monkey
9. Abuse liability of flunitrazepam among methadone-maintained patients
10. Generalized tonic-clonic seizures following withdrawal of therapeutic dose of bromazepam
11. Midazolam cue in rats: generalization tests with anxiolytic and other drugs
12. Characteristics of benzodiazepine abuse in methadone maintenance treatment patients: a 1 year prospective study in an Israeli clinic
13. Studies on benzodiazepines and opioids administered alone and in combination in rhesus monkeys: ventilation and drug discrimination
14. Discriminative stimulus effects of flumazenil in untreated and in diazepam-treated monkeys
15. Kinetics of five benzodiazepine hypnotics in healthy subjects
16. Discriminative-stimulus effects of triazolam and midazolam in rhesus monkeys
17. Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam
18. Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity
19. Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor
20. The Committee on Problems of Drug Dependence: a legacy of the National Academy of Sciences: a historical account
21. Flunitrazepam and triazolam: a comparison of behavioral effects and abuse liability
22. Discriminative and reinforcing effects of brotizolam in rhesus monkeys
23. Progress report from the testing program for stimulant and depressant drugs (1990)
24. Dependence liability of halazepam may be due to its metabolite nordiazepam
25. Long-term therapeutic use of benzodiazepines: 1. Effects of abrupt discontinuation
26. Flunitrazepam consumption among heroin addicts admitted for in-patient detoxification
27. Rohypnol ('Roofies') control of drug discrimination: effect of coadministered ethanol or flumazenil
28. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens
29. Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect
30. Abuse liability of flunitrazepam
31. Evaluation of the reinforcing and discriminative stimulus effects of γ-hydroxybutyrate in rhesus monkeys
32. Discriminative stimulus properties of midazolam: comparison with other benzodiazepines
33. Stimulus properties of benzodiazepines: correlations with binding affinities, therapeutic potency, and structure activity relationships (SAR)
34. Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat
35. Substitution of temazepam and midazolam in pentobarbital-dependent rats
36. Substitution of psychoactive drugs in pentobarbital-dependent rats