Nonadrenergic, noncholinergic relaxation of human isolated corpus cavernosum induced by scorpion venom

Urology

Volumn 57, Issue 4, 2001, Pages 816-820

  Teixeira, Cleber E ^a   Faro, Renato ^a   Moreno, Ronilson A ^a   Netto, Nelson Rodrigues ^a   Fregonesi, Adriano ^a   Antunes, Edson ^a   De Nucci, Gilberto ^a  

^a Faculty of Medical Sciences   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARGININE; ATROPINE; BRADYKININ; HISTAMINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN; PROSTAGLANDIN SYNTHASE INHIBITOR; SCORPION VENOM; TETRODOTOXIN;

ADULT; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; HUMAN; IN VITRO STUDY; INNERVATION; MALE; PATHOPHYSIOLOGY; PENIS; PENIS ERECTION; PHYSIOLOGY; PRIAPISM; SECRETION;

ACETYLCHOLINE; ADULT; ARGININE; ATROPINE; BRADYKININ; CYCLOOXYGENASE INHIBITORS; HISTAMINE; HUMANS; INDOMETHACIN; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOREPINEPHRINE; PENILE ERECTION; PENIS; PRIAPISM; SCORPION VENOMS; TETRODOTOXIN;

EID: 0035320480     PISSN: None     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/S0090-4295(00)01047-5     Document Type: Article

References (30)

1. K.-E Andersson G Wagner Physiology of penile erection Physiol Rev 75 1995 191 236
2. S.E Lerner A Melman G.J Christ A review of erection dysfunction new insights and more questions J Urol 149 1993 1246 1255
3. A.L Burnett C.J Lowenstein D.S Bredt Nitric oxide a physiologic mediator of penile erection Science 257 1992 401 403
4. J.P.M Finberg S Levy Y Vardi Inhibition of nerve stimulation-induced vasodilation in corpora cavernosa of the pithed rat by blockade of nitric oxide synthase Br J Pharmacol 108 1993 1038 1042
5. H.H Knispel C Goessl R Beckmann Nitric oxide mediates neurogenic relaxation induced in rabbit cavernous smooth muscle by electric field stimulation Urology 40 1996 471 476
6. C.E Teixeira A.C Bento R.A.B Lopes-Martins Tityus serrulatus scorpion venom relaxes the isolated rabbit corpus cavernosum by activating NANC nitrergic nerve fibers Br J Pharmacol 123 1998 435 442
7. H Hayashida T Okamura T Tomoyoshi Neurogenic nitric oxide mediates relaxation of canine corpus cavernosum J Urol 155 1996 1122 1127
8. T Okamura K Ayajiki N Toda Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves Am J Physiol 274 1998 H1075 H1081
9. A.M Leone N.P Wiklund T Hokfelt Release of nitric oxide by nerve stimulation in the human urogenital tract Neuroreport 24 1994 733 736
10. Couraud F, and Jover E: Mechanism of action of scorpion toxins, in Tu AT (Ed): Handbook of Natural Toxins. New York, Marcel Dekker, 1984, vol 2, pp 659–678.
11. J Simard D.D Watt Venoms and toxins G.A Polis The Biology of Scorpions 1990 Standford University Press Standford 414 444
12. H.S Bawaskar Diagnostic cardiac premonitory signs and symptoms of red scorpion sting Lancet 1 1982 552 554
13. Y Amitai Y Mines M Aker Scorpion sting in children a review of 51 cases Clin Pediatr 24 1985 136 140
14. Y Hershkovich Y Elitsur C.Z Margolis Criteria map audit of scorpion envenomation in Negev, Israel Toxicon 23 1985 845 854
15. L Freire-Maia Peripheral effects of Tityus serrulatus scorpion venom J Toxicol 14 1995 423 435
16. J.R Vane The use of isolated organs for detecting active substances in the circulating blood Br J Pharmacol Chemother 23 1964 360 373
17. L.J Ignarro P.A Bush G.M Buga Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle Biochem Biophys Res Commun 170 1990 843 850
18. P.A Bush N.E Gonzalez L.J Ignarro Biosynthesis of nitric oxide and citrulline from l -arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum Biochem Biophys Res Commun 186 1992 308 314
19. Holmquist F, Andersson K-E, and Hedlund H: Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man. J Physiol (Lond) 449: 295–311, 1992.
20. R.S Pickard P.H Powell M.A Zar The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle Br J Pharmacol 104 1991 755 759
21. J Rajfer W.J Aronson P.A Bush Nitric oxide as mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission N Engl J Med 326 1992 90 94
22. J Garthwaite E Southam C.L Boulton Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-alquinoxalin-1-one] Mol Pharmacol 48 1995 184 188
23. A.L Burnett S.L Tillman T.S.K Chang Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis J Urol 150 1993 73 76
24. F Trigo-Rocha G.-L Hsu C.F Donatucci The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection J Urol 149 1993 872 877
25. J.R Smythies F Benington R.D Morin Model for the action of tetrodotoxin and batrachotoxin Nature 231 1971 188 190
26. P.K Moore P Wallace Z.A Gaffen Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles antinociceptive and cardiovascular effects Br J Pharmacol 110 1993 219 224
27. B Mayer P Klatt E.R Werner Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole Neuropharmacology 33 1994 1253 1259
28. D.J Wolff A Lubeskie C Umansky The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents Arch Biochem Biophys 314 1994 360 366
29. Bücherl W: Classification, biology, and venom extraction of scorpions, in Bücherl W, and Buckley EE (Eds): Venomous Animals and Their Venoms. New York, Academic Press, 1971, vol 3, pp 317–347.
30. G Cotter E Kaluski A Blatt L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock Circulation 101 2000 1358 1361