Neurogenic nitric oxide mediates relaxation of canine corpus cavernosum

Journal of Urology

Volumn 155, Issue 3, 1996, Pages 1122-1127

  Hayashida, Hideshi ^a   Okamura, Tomio ^a   Tomoyoshi, Tadao ^a   Toda, Noboru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

cyclic GMP; nitric oxide; vasoactive intestinal polypeptide

Indexed keywords

CYCLIC GMP; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; CORPUS CAVERNOSUM; DOG; ELECTROSTIMULATION; IMMUNOHISTOCHEMISTRY; MALE; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VASODILATATION;

EID: 0030053478     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)66404-8     Document Type: Article

References (24)

1. Saenz de Tejada, I., Blanco, R., Goldstein, I., Azadzoi, K., de las Morenas, A., Krane, R. J. and Cohen, R. A.: Cholinergic neurotransmission in human corpus cavernosum. I. Response of isolated tissue. Am. J. Physiol., 254: H459, 1988.
2. Willis, E., Ottesen, B., Wagner, G., Sundler, F. and Fahrenkrug, J.: Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection. Acta Physiol. Scand., 113: 545, 1981.
3. Polak, J. M., Mina, S., Gu, J. and Bloom, S. R.: VIPergic nerves in the penis. Lancet, ii: 217, 1981.
4. Juenemann, K. P., Lue, T. F., Luo, J. A. and Dallah, S. A.: Polypeptide as a neurotransmitter in canine penile erection: a combined in vivo and immunohistochemical study. J. Urol., 138: 871, 1987.
5. Burnett, A. L., Lowenstein, C. J., Bredt, D. S., Chang, T. S. K. and Snyder, S. H.: Nitric oxide: a physiologic mediator of penile erection. Science, 257: 401, 1992.
6. Toda, N.: Nicotine-induced relaxation in isolated canine cerebral arteries. J. Pharmacol. Exp. Ther., 193: 376, 1975.
7. Toda, N. and Okamura, T.: Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle. Biochem. Biophys. Res. Commun., 170: 308, 1990.
8. Toda, N. and Okamura, T.: Role of nitric oxide in neurally induced cerebroarterial relaxation. J. Pharmacol. Exp. Ther., 258: 1027, 1991.
9. ω-momomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries. Jpn. J. Pharmacol., 52: 170, 1990.
10. Toda, N. and Okamura, T.: Mechanism underlying the response to vasodilator nerve stimulation in isolated dog and monkey cerebral arteries. Am. J. Physiol., 259: H1511, 1990.
11. Nedergaard, O. A.: Effect of nicotine on neuroeffector transmission in blood vessels. In: The Pharmacology of Nicotine. Edited by M. Rand and K. Thurau. Washington, D.C.: IRL Press, pp. 143-162, 1988.
12. 2 as a VIP antagonist. Endocrinology, 116: 2643, 1985.
13. Martin, W., Smith, J. A. and White, D. G.: The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor. Br. J. Pharmacol., 89: 563, 1986.
14. Gruetter, C. A., Kadowitz, P. J. and Ignarro, L. J.: Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, nitrite, and amyl nitrite. Can. J. Physiol. Pharmacol., 59: 150, 1982.
15. Kim, N., Azadzoi, K. M., Goldstein, I. and Saenz de Tejada, I.: A nitric oxide-like factor mediates nonadrenergic noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J. Clin. Invest., 88: 112, 1991.
16. Kimura, K., Tamura, M., Kawanisi, Y. and Kagawa, S.: Nitric oxide (NO) as non-adrenergic non-cholinergic neurotransmitter in human corpus cavernosum. Jpn. J. Pharmacol., 58: 385, 1992.
17. Bredt, D. S., Hwang, P. M. and Snyder, S. H.: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 347: 768, 1990.
18. Gillespie, J. S. and Sheng, H.: The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and bovine retractor penis muscle. Br. J. Pharmacol., 99: 194, 1990.
19. Ayajiki, K., Okamura, T. and Toda, N.: Nitric oxide mediates, and acetylcholine modulates, neurally induced relaxation of bovine cerebral arteries. Neuroscience, 54: 819, 1993.
20. Toda, N., Kitamura, Y. and Okamura, T.: Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro. Am. J. Physiol., 266: H1985, 1994.
21. Toda, N., Zhang, J.-X., Ayajiki, K. and Okamura, T.: Mechanisms underlying endothelium-independent relaxation by acetylcholine in canine retinal and cerebral arteries. J. PharmacoL Exp. Ther., 274: 1507, 1995.
22. Burnstock, G.: Local purinergic regulation of blood pressure. In: Vasodilatation. Edited by P. M. Vanhoutte, New York: Raven Press, pp. 1-14, 1988.
23. Lee, P. M.: Smoking and Alzheimer's disease: a review of the epidemiological evidence. Neuroepidemiology, 13: 134, 1994.
24. Toda, N. and Okamura, T.: Regulation by nitroxidergic nerve of arterial tone. News Physiol. Sci., 7: 148, 1992.