Reactive and Clonal Thrombocytosis: Proinflammatory and Hematopoietic Cytokines and Acute Phase Proteins

Southern Medical Journal

Volumn 94, Issue 4, 2001, Pages 417-420

  Araneda, Marco ^b   Krishnan, Vinodini ^b   Hall, Kenton ^b   Kalbfleisch, John ^b   Krishnaswamy, Guha ^b   Krishnan, Koyamangalath ^a  

^a East Tennessee State University   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; THROMBOPOIETIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CASE CONTROL STUDY; CLASSIFICATION; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; STANDARD; THROMBOCYTE COUNT; THROMBOCYTOSIS; VALIDATION STUDY;

ADULT; AGED; ANALYSIS OF VARIANCE; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-11; INTERLEUKIN-3; INTERLEUKIN-6; MALE; MIDDLE AGED; PLATELET COUNT; SENSITIVITY AND SPECIFICITY; THROMBOCYTOSIS; THROMBOPOIETIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035319387     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007611-200104000-00012     Document Type: Article

References (25)

1. Murphy S: Thrombocytosis and thrombocythemia. Clin Hematol 1983; 12:89-105
2. Tefferi A, Hoagland H: Issues in the diagnosis and management of essential thrombocythemia. Mayo Clinic Proc 1994; 69:651-655
3. Mitus AJ, Schafer AI: Thrombocytosis and thrombocythemia. Hematol Oncol Clin North Am 1990; 4:157-178
4. Begley CG: Clinical studies with megakaryocyte growth and development factor (Mpl-ligand). Thromb Haemost 1997; 78:42-46
5. Suen Y, Chang M, Lee S, et al: Regulation of interleukin- II protein and mRNA expression in neonatal and adult fibroblasts and endothelial cells. Blood 1994; 84:4125-4134
6. Fanuchi M, Glaspy J, Crawford J, et al: Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997; 336:404-409
7. Schweiger C, Farber L, Meinerz W: Effective stimulation of thrombopoiesis with interleukin-3 (IL-3) in chemotherapy-induced myelosuppression - a case report. Eur J Cancer 1995; 31A:425
8. Borish L, Rosenwasser L: Update on cytokines. J Allergy Clin Immunol 1996; 97:719-734
9. Tefferi A, Ho TC, Ahmann GJ, et al: Plasma interleukin-6 and C-reactive protein levels in reactive versus clonal thrombocytosis. Am J Med 1994; 97:374-378
10. Custodi P, Cerutti A, Balduini C: Which tests are most useful for distinguishing between clonal and reactive thrombocytosis? Am J Med 1996; 101:233-235
11. Holien CW, Henthorn J, Koziol JA, et al: Serum interleukin-6 levels in patients with thrombocytosis. Leukemia Lymphoma 1992; 8:235-241
12. Blay JY: Role of interleukin-6 in paraneoplastic thrombocytosis. Br J Cancer 1997; 75:283-286
13. Higashihara M, Sunaga S, Tange T, et al: Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis. Cancer 1992; 70:2105-2108
14. Estrov Z, Talpaz M, Mavligit G, et al: Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. Am J Med 1995; 98:551-558
15. Hsu HC, Tsai WH, Jiang ML, et al: Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis. J Lab Clin Med 1999; 134:392-397
16. Sasaki Y, Takahashi T, Miyazaki H, et al: Production of thrombopoietin by human carcinomas and its novel isoforms. Blood 1999; 94:1952-1960
17. Heits F, Stahl M, Ludwig D, et al: Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. J Interferon Cytokine Res 1999; 19:757-760
18. Espanol I, Hernandez A, Cortes M, et al: Patients with thrombocytosis have normal or slightly elevated thrombopoietin levels. Haematologica 1999; 84:312-316
19. Uppenkamp M, Makarova E, Petrasch S, et al: Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis. Ann Hematol 1998; 77:217-223
20. Hou M, Carneskog J, Mellqvist UH, et al: Impact of endogenous thrombopoietin levels on the differential diagnosis of essential thrombocythemia and reactive thrombocytosis. Eur J Haematol 1998; 61:119-122
21. Cerutti A, Custodi P, Mduranti, et al: Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant. Clin Lab Haematol 1999; 21:271-275
22. Pitcher L, Taylor K, Nichol J, et al: Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia. Br J Haematol 1997; 99:929-932
23. Cerutti A, Custodi P, Duranti M, et al: Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br J Haematol 1997; 99:281-284
24. Moliterno AR, Hankins WD, Spivak JL: Impaired expression of the thrombopoietin receptor by platelets derived from patients with polycythemia. N Engl J Med 1998; 338:572-580
25. Tefferi A, Yoon SY, Li CY: Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis. Blood 2000; 96:771-772