Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen

Journal of Veterinary Medical Science

Volumn 63, Issue 4, 2001, Pages 413-419

  Iwasaki, Tadashi ^a,b   Tanaka, Akane ^b   Itakura, Atsuko ^b   Yamashita, Naomi ^c   Ohta, Ken ^c   Matsuda, Hiroshi ^b   Onuma, Misao ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Allergy; Cytokine; Eosinophil; In vivo animal model; Lung

Indexed keywords

ANIMALIA;

ACETYLCHOLINE; ANTIGEN; CHEMOKINE; IMMUNOGLOBULIN E; MESSENGER RNA; OVALBUMIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; ASTHMA; ATOPIC DERMATITIS; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CHEMISTRY; CYTOCHEMISTRY; DISEASE MODEL; EOSINOPHILIA; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; LUNG; LUNG LAVAGE; MOUSE; PATHOLOGY; RAT; WISTAR RAT;

ACETYLCHOLINE; ANIMALS; ANTIGENS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; EOSINOPHILIA; HISTOCYTOCHEMISTRY; IMMUNOGLOBULIN E; LUNG; MICE; MICE, INBRED BALB C; OVALBUMIN; RATS; RATS, WISTAR; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0035316832     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.63.413     Document Type: Article

References (28)

1. Alam, R., York, J., Boyars, M, Stafford, S., Grant, J. A, Lee, J., Forsythe, P., Sim, T and Ida, N. 1996. Increased MCP-1, RANTES, and MIP-1α in bronchoalveolar lavage fluid of allergic asthmatic patients. Am. J. Respir. Crit. Care Med. 153: 1398-1404.
2. Ann, J. P. and Lee, T. H. 1992. The pathology of bronchial asthma. Adv. Immunol. 51: 323-382.
3. Bochner, B. S., Undem, B. J. and Lichtenstein, L. M. 1994. Immunological aspects of allergic asthma. Annu. Rev. Immunol. 12:295-335.
4. Brofman, J D., White, S. R., Blake, J. S., Munoz, N. M., Gleich, G. J. and Leff, A. R. 1989. Epithelial augmentation of trachial contraction caused by major basic protein of eosinophils. J. Appl. Physiol. 66: 1867-1873.
5. Burke-Gaffney, A. and Hellewell, P. G. 1996. Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cells. Biochem. Biophys Res. Commun. 227: 35-40
6. Clutterbuck, E J., Hirst, E. M. and Sanderson, C. J. 1989. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparisons and interactions with IL-1, IL-3, IL-6, and GM-CSF. Blood 73: 1504-1509.
7. Coyle, A. J., Ackerman, S. J., Burch, R., Proud, D. and Irvin, C. G. 1995. Human eosinophil-granule major basic protein and synthetic polycations induce airway responsiveness in vivo dependent upon bradykinin generation. J. Clin. Invest. 95: 1735-1740.
8. Gonzaro, J A, Jia, G. O., Aguirre, V., Friend, D., Coyle, A. J., Jenkins, N.A., Lin, G.-S., Katz, H., Lichtman, A, Copeland, N., Kopf, M. and Gutierrez-Ramos, J. C. 1996. Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but is not restricted to a Th2 type response. Immunity 4: 1-14.
9. Holgate, S. T. 1993. Asthma-Pathophysiology. pp. 13.1-13.21. In: Allergy (Holgate, S.T. and Church, M.K. eds), Gower Medical Publishing, London.
10. Hopp, R. J., Bewtra, A K., Biven, R., Nair, N. M. and Wenley, T. R. G. 1988. Bronchial reactivity pattern in non-asthmatic parents of asthmatics. Ann. Allergy 61: 184-186.
11. Hopp, R. J, Townley, R. G., Biven, R. E, Bewtra, A. K. and Nair, N. M. 1990. The presence of airway reactivity before the development of asthma. Am Rev. Respir. Dis. 141: 2-8.
12. Kumar, R. K. 1995. Experimental models in pulmonary pathology. Pathology 21: 130-132.
13. Li, X.-M., Schofield, B. H., Wang, Q.-F., Kim, K.-H. and Huang, S.-K. 1998 Induction of pulmonary allergic responses by antigen-specific Th2 cells. J. Immunol. 160: 1378-1384.
14. Matsuda, H., Watanabe, N., Geba, G. P., Sperl, J., Tsudzuki, M., Hiroi, J., Matsumoto, M., Ushio, H., Saito, S., Askenase, P. W. and Ra, C. 1997 Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int. Immunol. 9: 461-466.
15. Matsumoto, M., Ra, C., Kawamoto, K., Sato, H., Itakura, A., Sawada, J., Ushio, H., Suto, H., Mitsuishi, K., Hikasa, Y. and Matsuda, H. 1999. IgE hyperproduction through enhanced tyrosine phosphorylation of Janus Kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J. Immunol. 162: 1056-1063.
16. Motojima, S., Figas, E., Loegering, D. A. and Gleich, G. J. 1989. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am. Rev. Respir. Dis. 139: 801-805.
17. Ohta, K., Yamashita, N., Tajima, M., Miyasaka, T., Nakano, J., Nakajima, M., Ishii, A., Horiuchi, T., Mano, K. and Miyamoto, T. 1999. Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: Essential role of GM-CSF. J. Allergy Clin. Immunol. 104: 1024-1030.
18. Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I. M., Meyers, D. A. and Levitt, R. C. 1995. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. New Engl. J. Med. 333: 894-900.
19. + T cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol. 92: 313-324.
20. Rothenberg, M. E., MacLean, J. A., Pearlman, E., Luster, A. D. and Leder, P. 1997. Target disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185: 785-790.
21. Salob, S. P. and Atherton, D. J. 1993. Prevalence of respiratory symptoms in children with atopic dermatitis attending pediatric dermatology clinics. Pediatrics 91: 8-15.
22. Sears, M. R., Burrows, B., Flannery, E. M., Herbison, G. P. and Hewitt, C. J. 1991. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. New Engl. J. Med. 325: 1067-1071.
23. + cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. J. Clin. Invest. 100: 2466-2475.
24. Seminario, M.-C. and Gleich, G. J. 1994. The role of eosinophils in the pathogenesis of asthma. Curr. Opin. Immunol. 6: 860-864.
25. Smith, H. 1992. Asthma, inflammation, eosinophils and bronchial hyperresponsiveness. Clin. Exp. Allergy 22: 187-197.
26. Strath, M., Warren, D. J. and Scanderson, C. J. 1985. Detection of eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors. J. Immunol. Methods 83: 209-215.
27. Vestergaad, C., Yoneyama, H., Murai, M., Nakamura, K., Tamaki, K., Terashima, Y., Imai, T., Yoshie, O., Irimura, T., Mizutani, H. and Matsushima, K. 1999. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 104: 1097-1105.
28. Watanabe, N., Kobayashi, A., Miyajima, H., Hirano, T. and Ovary, Z. 1987. Detection of IgE antibody-forming cells by passive cutaneous anaphylaxis using cell extract from lymphoid organs. J. Immunol. Methods 96: 41.