Reduced oxygen uptake during steady state exercise after 21-day mountain climbing expedition to 6,194 m

Canadian Journal of Applied Physiology

Volumn 26, Issue 2, 2001, Pages 143-156

  MacDonald, Maureen J ^a   Green, Howard J ^a   Naylor, Heather L ^a   Otto, Christian ^a   Hughson, Richard L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Altitude; Doppler ultrasound; Hypoxia; Leg blood flow; Work efficiency

Indexed keywords

ACCLIMATIZATION; ADAPTATION; ADULT; ALTITUDE; ARTICLE; BLOOD FLOW; EXERCISE; HOMEOSTASIS; HUMAN; LEG; LUNG GAS EXCHANGE; MALE; MOUNTAINEERING; OXYGEN CONSUMPTION; PHYSIOLOGY; VASCULARIZATION;

ACCLIMATIZATION; ADAPTATION, PHYSIOLOGICAL; ADULT; ALTITUDE; EXERCISE; HOMEOSTASIS; HUMANS; LEG; MALE; MOUNTAINEERING; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; REGIONAL BLOOD FLOW;

EID: 0035316265     PISSN: 10667814     EISSN: None     Source Type: Journal    
DOI: 10.1139/h01-010     Document Type: Article

References (33)

1. Bender, P.R., Groves, B.M., McCullough, R.E., McCullough, R.G., Huang, S.Y., Hamilton, A.L., Wagner, P.D., Cymerman, A., and Reeves, J.T. (1988). Oxygen transport to exercising leg in chronic hypoxia. J. Appl. Physiol. 65: 2592-2597.
2. Böning, D., Maassen, N., Jochum, F., Steinacker, J., Halder, A., Thomas, A., Schmidt, W., Noé, G., and Kubanek, B. (1997). After-effects of a high altitude expedition on blood. Int. J. Sports Med. 18: 179-185.
3. Brooks, G.A., Butterfield, G.E., Wolfe, R.R., Groves, B.M., Mazzeo, R.S., Sutton, J.R., Wolfel, E.E., and Reeves, J.T. (1991). Decreased reliance on lactate during exercise after acclimatization to 4,300 m. J. Appl. Physiol. 71: 333-341.
4. Coyle, E.F., Sidossis, L.S., Horowitz, J.F., and Beltz, J.D. (1992). Cycling efficiency is related to the percentage of Type 1 muscle fibers. Med. Sci. Sports Exerc. 24: 782-788.
5. di Prampero, P.E. (1981). Energetics of muscular exercise. Rev. Physiol. Biochem. Pharmacol. 89: 143-222.
6. Dyke, C.K., Proctor, D.N., Dietz, N.M., and Joyner, M.J. (1995). Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. J. Physiol. (Lond.) 488: 259-265.
7. Erkintalo, M., Bendahan, D., Mattéi, J.P., Fabrguettes, C., Vague, P., and Cozzone, P.J. (1998). Reduced metabolic efficiency of skeletal muscle energetics in hyperthyroid patients evidenced quantitatively by in vivo phosphorus-31 magnetic resonance spectroscopy. Metabolism 47: 769-776.
8. Favier, R., Spielvogel, H., Desplanches, D., Ferretti, G., Kayser, B., and Hoppeler, H. (1995). Maximal exercise performance in chronic hypoxia and acute normoxia in high-altitude natives. J. Appl. Physiol. 78: 1868-1874.
9. Fulco, C.S., Rock, P.B., and Cymerman, A. (1998). Maximal and submaximal exercise performance at altitude. Aviat. Space Environ. Med. 69: 793-801.
10. Grassi, B., Marzorati, M., Kayser, B., Bordini, M., Colombini, A., Conti, M., Marconi, C., and Cerretelli, P. (1996). Peak blood lactate and blood lactate vs workload during acclimatization to 5,050 m and in deacclimatization. J. Appl. Physiol. 80: 685-692.
11. Hackney, A.C., Feith, S., Pozos, R., and Seale, J. (1995). Effects of high altitude and cold exposure on resting thyroid hormone concentrations. Aviat. Space Environ. Med. 66: 325-329.
12. Hochachka, P.W. (1998). Mechanism and evolution of hypoxia-tolerance in humans. J. Exp. Biol. 201: 1243-1254.
13. Hochachka, P.W., Gunga, H.C., and Kirsch, K. (1998). Our ancestral physiological phenotype: An adaptation for hypoxia tolerance and for endurance performance? Proc. Natl. Acad. Sci. USA 95: 1915-1920.
14. Hochachka, P.W., Stanley, C., Matheson, G.O., McKenzie, D.C., Allen, P.S., and Parkhouse, W.S. (1991). Metabolic and work efficiencies during exercise in Andean natives. J. Appl. Physiol. 70: 1720-1730.
15. 2 on blood flow dynamics at the onset of forearm exercise. J. Appl. Physiol. 81: 1619-1626.
16. Hurtado, A. (1964). Animals in high altitudes: Resident man. In: D.B. Dill (Ed.), Handbook of Physiology, pp. 843-868. Washington, DC: American Physiological Society.
17. Linnarsson, D. (1974). Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol. Scand. 415 (Suppl.): 1-68.
18. Linnarsson, D., Karlsson, J., Fagraeus, L., and Saltin, B. (1974). Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J. Appl. Physiol. 36: 399-402.
19. MacDonald, M.J., Shoemaker, J.K., Tschakovsky, M.E., and Hughson, R.L. (1998). Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J. Appl. Physiol. 85: 1622-1628.
20. 2/DWR during moderate exercise [Abstract]. Med. Sci. Sports Exerc. 31:S333.
21. Matheson, G.O., Allen, P.S., Ellinger, D.C., Hanstock, C.C., Gheorghiu, D., McKenzie, D.C., Stanley, C., Parkhouse, W.S., and Hochachka, P.W. (1991). Skeletal muscle metabolism and work capacity: A 31P-NMR study of Andean native and lowlanders. J. Appl. Physiol. 70: 1963-1976.
22. Morgan, D.W., Strohmeyer, H.S., Daniels, J.T., Beaudoin, C.C., Craib, M.W., Borden, R.A., Greer, P.J., and Burleson, C.L. (1996). Short term changes in 10-km race pace aerobic demand and gait mechanics following a bout of high-intensity distance running. Eur. J. Appl. Physiol. 73: 267-272.
23. Murphy, P.C., Cuervo, L.A., and Hughson, R.L. (1989). Comparison of ramp and step exercise protocols during hypoxic exercise in man. Cardiovasc. Res. 23: 825-832.
24. Niu, W., Wu, Y., Li, B., Chen, N., and Song, S. (1995). Effects of long-term acclimatization in lowlanders migrating to high altitude: Comparison with high altitude residents. Eur. J. Appl. Physiol. 71: 543-548.
25. Roberts, A.C., Butterfield, G.E., Cymerman, A., Reeves, J.T., Wolfel, E.E., and Brooks, G.A. (1996). Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. J. Appl. Physiol. 81: 1762-1771.
26. Rose, M.S., Houston, C.S., Fulco, C.S., Coates, G., Sutton, J.R., and Cymerman, A. (1988). Operation Everest II: Nutrition and body composition. J. Appl. Physiol. 65: 2545-2551.
27. Rowell, L.B., Saltin, B., Kiens, B., and Christensen, N.J. (1986). Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia? Am. J. Physiol. 251: H1038-H1044.
28. Savourey, G., Garcia, N., Caravel, J.P., Gharib, C., Pouzeratte, N., Martin, S., and Bittel, J. (1998). Pre-adaptation, adaptation and de-adaptation to high altitude in humans: Hormonal and biochemical changes at sea level. Eur. J. Appl. Physiol. Occup. Physiol. 77: 37-43.
29. Segal, S.S. (1994). Cell-to-cell communication coordinates blood flow control. Hypertension 23: 1113-1120.
30. Shoemaker, J.K., MacDonald, M.J., and Hughson, R.L. (1997). Time course of brachial artery diameter responses to rhythmic handgrip exercise in humans. Cardiovasc. Res. 35: 125-131.
31. Whipp, B.J., and Ward, S.A. (1990). Physiological determinants of pulmonary gas exchange kinetics during exercise. Med. Sci. Sports Exerc. 22: 62-71.
32. Winter, D.A. (1979). A new definition of mechanical work done in human movement. J. Appl. Physiol. 46: 79-83.
33. Wolfel, E.E., Groves, B.M., Brooks, G.A., Butterfield, G.E., Mazzeo, R.S., Moore, L.G., Sutton, J.R., Bender, P.R., Dahms, T.E., McCullough, R.E., McCullough, R.G., Huang, S.Y., Sun, S.F., Grover, R.F., Hultgren, H.N., and Reeves, J.T. (1991). Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136.