Chromosomal aberrations in lymphocytes of employees in transformer and generator production exposed to electromagnetic fields and mineral oil

Bioelectromagnetics

Volumn 22, Issue 3, 2001, Pages 150-160

  Skyberg, Knut ^a   Hansteen, Inger Lise ^b   Vistnes, Arnt I ^c  

^a NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

^b TELEMARK HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

DNA repair inhibition; Genotoxic effect; High voltage workers; Pulse testing; Spark discharges

Indexed keywords

CHROMOSOMES; DNA; ELECTRIC DISCHARGES; ELECTRIC TRANSFORMER TESTING; ELECTROMAGNETIC FIELDS; INSULATING OIL; LYMPHOCYTES; MINERALS; REPAIR; RISK ASSESSMENT;

CHROMOSOMAL ABERRATION; DNA REPAIR INHIBITION; DNA-REPAIR; GENOTOXIC EFFECTS; HIGH VOLTAGE LABORATORIES; HIGH-VOLTAGE WORKER; HIGH-VOLTAGES; PULSE TESTING; SPARK DISCHARGE; WORKERS';

MINERAL OILS;

MINERAL OIL;

ADULT; ARTICLE; CHROMATID; CHROMOSOME ABERRATION; COFFEE; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; CYTOLOGY; DNA REPAIR; DNA REPLICATION; DRINKING BEHAVIOR; DRUG EFFECT; ELECTROMAGNETIC FIELD; ENVIRONMENTAL EXPOSURE; HUMAN; LYMPHOCYTE; MIDDLE AGED; NORWAY; OCCUPATIONAL EXPOSURE; QUESTIONNAIRE; RADIATION EXPOSURE; REFERENCE VALUE; RETROSPECTIVE STUDY; SMOKING;

ADULT; ALCOHOL DRINKING; CHROMATIDS; CHROMOSOME ABERRATIONS; COFFEE; CROSS-SECTIONAL STUDIES; DNA REPAIR; DNA REPLICATION; ELECTROMAGNETIC FIELDS; ENVIRONMENTAL EXPOSURE; HUMANS; LYMPHOCYTES; MIDDLE AGED; MINERAL OIL; NORWAY; OCCUPATIONAL EXPOSURE; QUESTIONNAIRES; REFERENCE VALUES; RETROSPECTIVE STUDIES; SMOKING;

EID: 0035315783     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/bem.33     Document Type: Article

References (26)

1. 2 in human lymphocytes by very low doses (0.025-0.4 Gy) of X-rays in combination with inhibitors of DNA synthesis. Mutat Res 141:45-48.
2. Antonopoulos A, Yang B, Stamm A, Heller W-D, Obe G. 1995. Cytological effects of 50 Hz electromagnetic fields on human lymphocytes in vitro. Mutat Res 346:151-157.
3. Ardito G, Lamberti L, Bigatti P, Prono G. 1984. Influence of a constant magnetic field on human lymphocyte cultures. Boll Soc It Biol Sper 60:1341-1346.
4. Armstrong B, Thériault G, Guénel P, Deadman J, Goldberg M, Héroux P. 1994. Association between exposure to pulsed electromagnetic fields and cancer in electrical utility company workers from Québec, Canada and France. Am J Epidemiol 140:805-820.
5. Hagmar L, Bonassi S, Strömberg U, Brøgger A, Knudsen LE, Norppa H et al. 1998. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res 58:4117-4121.
6. Hansson K, Palitti F, Kihlman BA, Karlsson MB. 1982. Potentation of X-ray and streptonigrin-induced chromosomal aberrations in human lymphocytes by post-treatments with hydroxyurea and caffeine. Hereditas 97:51-58.
7. Jelmert Ø, Hansteen I-L, Langård S. 1992. Enhanced cytogenetic detection of previous in vivo exposure to mutagens in human lymphocytes after treatment with inhibitors of DNA-synthesis and DNA-repair in vitro. Mutat Res 271:289-298.
8. Kihlman BA, Andersson HC. 1986. Effects of inhibitors of DNA repair on the frequencies of chromosomal aberrations induced by X-rays or alkylating agents in cultured human lymphocytes. Prog Clin Biol Res 209A:395-402.
9. Lialiaris T, Mourelatos D, Dozi-Vassiliades J. 1988. Enhancement of cytogenetic damage by chloropromazine in human lymphocytes treated with alkylating antineoplastics and caffeine. Mutat Res 206:361-365.
10. Löscher W, Mevissen M. 1995. Linear relationship between flux density and tumor co-promoting effect of prolonged magnetic field exposure in a breast cancer model. Cancer Lett 96:175-180.
11. Lövsund P, Öberg PÅ, Nilsson SEG. 1979. Influence on vision of extremely low frequency electromagnetic fields. Acta Ophthalmol 57:812-821.
12. McCann J, Dietricn F, Rafferty C, Martin AO. 1993. A critical review of the genotoxic potential of electric and magnetic fields. Mutat Res 297:61-95
13. McCann J, Dietrich F, Rafferty C. 1993. The genotoxic potential of electric and magnetic fields: an update. Mutat Res 411:45-86.
14. McLean J, Thansandote A, Lecuyer D, Goddard M, Tryphonas L, Scaiano JC, Johnson F. 1995. A 60-Hz magnetic field increases the incidence of squamous cell carcinomas in mice previously exposed to chemical carcinogens. Cancer Lett 92:121-125.
15. National Radiological Protection Board's Advisory Group on Nonionising Radiation. 1992. Electromagnetic fields and the risk of cancer. NRPB documents, Volume 3, no.1. Chilton, Oxon: National Radiation Protection Board. Chairman: Sir Richard Doll.
16. Nordenson I, Hansson Mild K, Andersson G, Sandström M. 1994. Chromosomal aberrations in human amniotic cells after intermittent exposure to fifty hertz magnetic fields. Bioelectromagnetics 15:293-301.
17. Portier CJ, Wolfe MS, editors. 1998. Assessment of health effects from exposure to power-line frequency electric and magnetic fields. Working Group Report from meeting in Brooklyn Park, Minnesota, 16-24. June 1998. Organized by the National Institute of Environmental Health Sciences (NIEHS) with support of the EMF Research and Public Information Dissemination (EMFRAPID). U.S. National Institutes of Health (NIH). Publication No. 98-3981. Full report on: www.niehs.nih.gov/emfrapid/home.htm
18. Rosenthal M, Obe G. 1989. Effects of 50-Hertz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. Mutat Res 210:329-335.
19. 2. Mutat Res 248:195-202.
20. Savitz DA, Ahlbom A. 1994. Epidemiologic evidence on cancer in relation to residential and occupational exposures. In: Carpenter DO, editor. Biological effects of electric and magnetic fields, Volume 2, Beneficial and harmful effects. San Diego: Academic Press, p 233-261.
21. Savitz DA, Loomis DP. 1995. Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141:123-134..
22. Skyberg K, Hansteen I-L, Jelmert Ø, Rønneberg A. 1989. A cytogenetic and haematological investigation of oil exposed workers in a Norwegian cable manufacturing company. Br J Ind Med 46:791-798.
23. Skyberg K, Hansteen I-L, Vistnes AI. 1993. Chromosome aberrations in lymphocytes of high-voltage laboratory cable splicers exposed to electromagnetic fields. Scand J Work Environ Health 19:29-34.
24. SPSS for Windows. 1999. SPSS Base 9.0. Applications guide. Chicago: SPSS Inc.
25. Testoni MI, López-Camelo JS, Bianchi MS, Bianchi NO. 1996. Enhancement of chromosome aberrations by the combination of DNA substitution with halogenated deoxyuridine and streptonigrin treatments. Mutat Res 359: 31-37.
26. Valjus J, Norppa H, Järventaus H, Sorsa M, Nykyri E, Salomaa S et al. 1993. Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields. Radiat Environ Biophys 32:325-336.