Enhancement of chromosome aberrations by the combination of DNA substitution with halogenated deoxyuridine and streptonigrin treatments

Mutation Research - Environmental Mutagenesis and Related Subjects

Volumn 359, Issue 1, 1996, Pages 31-37

  Testoni, Mariana I ^a   López Camelo, Jorge S ^a   Bianchi, Martha S ^a   Bianchi, Néstor O ^a  

^a Instituto Multidisciplinario de Biologia Celular   (Argentina)

Author keywords

Bromodeoxyuridine; Deoxyuridine; DNA substitution; Streptonigrin

Indexed keywords

BROXURIDINE; CAFFEINE; IDOXURIDINE; RUFOCROMOMYCIN;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; FEMALE; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0030044567     PISSN: 01651161     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1161(96)90007-2     Document Type: Article

References (20)

1. Beckman, R.P., M.J. Agostino, MM. McHugh, R.D. Sigmund and T.A. Beerman (1987) Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in marine cells by deoxyribonuclease I, bleomycin, neocarzinostatin, or ionizing radiation, Biochemistry, 26, 5409-5415.
2. Brown, T., G. Kneale, W.N. Hunter and O. Kennard (1986) Structural characterization of the bromourail-guanine base pair mismatch in a Z-DNA fragment, Nucleic Acids Res., 14, 1801-1809.
3. Capranico, G., M. Palumbo, S. Tinelli and F. Zunino (1994) Unique sequence specificity of topoisomerase II DNA cleavage stimulation and DNA binding mode of streptonigrin, J. Biol. Chem., 264, 25004-25009.
4. Chapman, D.J. (1980) Biophysical models of mammalian cell inactivation by radiation, in: R.E. Meyn and H.R. Withers (Eds.), Radiation Biology in Cancer Research, Raven, New York, pp. 21-32.
5. Dewey, W.C. and R.M. Humphrey (1965) Increase in radiosensitivity to ionizing radiation related to the replacement of thymine in mammalian cells with 5-bromo-deoxyuridine, Radiat. Res., 26, 538-553.
6. Dillehay, L.E., L.H. Thompson and A.V. Carrano (1984) DNA-strand break associated with halogenated pyrimidine incorporation, Mutation Res., 131, 129-136.
7. DuFrain, R.J. (1984) Probing sister chromatid exchange formation with halogenated pyrimidines, in: R.R. Tice and A. Hollaender (Eds.), Sister Chromatid Exchanges, Part A, Plenum, New York, pp. 41-58.
8. DuFrain, R.J., A.F. McFee, S. Linkous, C.J. Jennings and K.W. Lowe (1984) In vivo SCE analysis using bromodeoxyuridine, Mutation Res., 139, 57-60.
9. Fisher, R.A. and Yates F. (1957) Statistical Tables for Biological, Agricultural and Medical Research, 5th edn., Oliver and Boyd, London 1957, p. 61.
10. Goz, B. (1978) The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells, Pharmacol. Rev., 29, 249-272.
11. Heartlein, M.W., J.P. O'Neill, B.C. Pal and R.J. Preston (1982) The induction of specific-locus mutations and sister-chromatid exchanges by 5-bromo and 5-chlorodeoxyuridine, Mutation Res., 92, 411-416.
12. Kihlman, B.A. and Anderson H.C. (1985) Synergistic enhancement of the frequency of chromatid aberrations in cultured human lymphocytes by combinations of inhibitors of DNA repair, Mutation Res., 150, 313-325.
13. Kuo, M.T. (1981) Preferential damage of active chromatin by bleomycin, Cancer Res., 41, 2439-2443.
14. López-Larraza, D.M. and N.O. Bianchi (1993) DNA response to bleomycin in mammalian cells with variable degrees of chromatin condensation, Environ. Mol. Mutagen., 21, 258-264.
15. Sarma, R.H. and M.H. Sarma (1988) DNA double helix and the chemistry of cancer, Adenine, New York, pp. 1-254.
16. Smith, P.J., J. Mircheva and N.N. Bleheen (1986) Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoroperazine) in mouse tumor cells: DNA damage repair and chromatin changes, Br. J. Cancer, 53, 105-114.
17. Testoni, M.I., N.O. Bianchi and M.S. Bianchi (1995) The kinetics of chromosome and DNA damage by streptonigrin in CHO cells, Mutation Res., 334, 23-31.
18. Wolff, S. and N. Fijtman (1981) X-Ray sensitization of chromatids unifilarly and bifilarly substituted DNA, Mutation Res., 80, 133-140.
19. Zwanenburg, T.S.B., L.H.F. Mullenders, A.T. Natarajan and A.A. van Zeeland (1984) DNA lesions, chromosomal aberrations and G2 delay in CHO cells cultured in medium containing bromo- or chlorodeoxyuridine, Mutation Res., 127, 155-168.
20. Zwanenburg, T.S.B., A.A. van Zeeland and A.T. Natarajan (1985) Influence of incorporated bromodeoxyuridine on the induction of chromosomal alterations by ionizing radiation and long-wave UV in CHO cells, Mutation Res., 150, 283-292.