Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: Tissue-specific regulation of B-myb function

Blood

Volumn 97, Issue 7, 2001, Pages 2091-2097

  Müller Tidow, Carsten ^a   Wang, Wenbing ^b   Idos, Gregory E ^b   Diederichs, Sven ^b   Yang, Rong ^b   Readhead, Carol ^b   Berdel, Wolfgang E ^b   Serve, Hubert ^b   Saville, Mark ^b   Watson, Roger ^b   Phillip Koeffler, H ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN A1; CYCLIN DEPENDENT KINASE 2; GLUTATHIONE TRANSFERASE; ONCOPROTEIN; ONCOPROTEIN B MYB; PHOSPHOPEPTIDE; SERINE; THREONINE; TRYPSIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BLAST CELL; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CONTROLLED STUDY; HUMAN; MALE; MOUSE; NONHUMAN; ONCOGENE; PATHOGENESIS; PEPTIDE MAPPING; PRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SPERMATOGENESIS; TISSUE SPECIFICITY; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0035313379     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.7.2091     Document Type: Article

References (30)

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2. Cyclin A1 is required for meiosis in the male mouse
3. Regulation of meiosis during mammalian spermatogenesis: The A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage
4. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines
5. Cyclin A1 expression in leukemia and normal hematopoietic cells
6. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins
7. B-Myb: A key regulator of the cell cycle
8. Expression of C-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells
9. B-myb antisense oligonucleotides inhibit proliferation of human hematopoietic cell lines
10. Serial analysis of gene expression in non-small cell lung cancer
11. Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction
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13. Expression of B-Myb during mouse embryogenesis
14. Cell type-specific trans-activation by the B-myb gene product: Requirement of the putative cofactor binding to the c-terminal conserved domain
15. B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation
16. Activation of human B-MYB by cyclins
17. Cell-cycle regulation of B-Myb protein expression: Specific phosphorylation during the S phase of the cell cycle
18. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties
19. Phosphorylation of B-Myb regulates its transactivation potential and DNA binding
20. Regulation of B-Myb activity by cyclin D1
21. GC boxes are required for cell cycle regulated activation of the cyclin A1 promoter: Cloning of the gene and characterization of the promoter region
22. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
23. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression
24. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent
25. B-MYB transactivates its own promoter through SP1-binding sites
26. A distinct cyclin A is expressed in germ cells in the mouse
27. Functional antagonism between members of the myb family: B-myb inhibits v-myb-induced gene activation
28. Carboxy-terminal elements of c-Myb negatively regulate transcriptional activation in cis and in trans
29. The c-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions
30. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription