Melatonin prolongs survival of immunodepressed mice infected with the Venezuelan equine encephalomyelitis virus

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 95, Issue 2, 2001, Pages 207-210

  Bonilla, Ernesto ^a,b,d   Rodón, Carolina ^a   Valero, Nereida ^a   Pons, Héctor ^a   Chacín Bonilla, Leonor ^a   Tamayo, Jorge García ^c   Rodríguez, Zulay ^a   Medina Leendertz, Shirley ^b   Añez, Florencio ^a  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

^b Fundacite Zulia   (Venezuela)

^c UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^d UNIVERSIDAD DEL ZULIA   (Venezuela)

Author keywords

Dexamethasone; Experimental model; GM CSF; Immunosuppression; Interleukin 2; Melatonin; Mice; Venezuelan equine encephalomyelitis

Indexed keywords

DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; MELATONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENCEPHALOMYELITIS; IMMUNE DEFICIENCY; INOCULATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; SURVIVAL RATE; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALIA; EQUIDAE; RNA VIRUSES; VENEZUELAN EQUINE ENCEPHALITIS VIRUS;

EID: 0035295433     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(01)90170-1     Document Type: Article

References (34)

1. Glucocorticoid regulation of GM-CSF: Evidence for transcriptional mechanisms in airway epithelial cells
2. The pineal gland: A neurochemical transducer
3. Interleukin-1 and hematopoiesis
4. Effects of HSV-1, a neurotropic virus, on the hypothalamic-pituitary-adrenocortical axis in rats
5. Protective effects of melatonin in mice infected with encephalitis viruses
6. Cold stress-induced neuroinvasiveness of attenuated arboviruses is not solely mediated by corticosterone
7. Plaque formation by arboviruses
8. Mechanism of virus-induced stimulation of the hypothalamus-pituitary-adrenal axis
9. Circadian rhythms of pineal function in rats
10. Changes in serum and striatal free amino acids after Venezuelan equine encephalomyelitis virus
11. Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus
12. Melatonin increases brain levels of IL-1β and decreases TNFα during the murine infection with Venezuelan equine encephalitis virus
13. Melatonin restores immunodepression in aged and cyclophosphamide-treated mice
14. Reconstitution of T cell function in aging mice by thymosin α1
15. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: Role of inhibition of NFKappaB activation
16. Arboviruses
17. Effects of melatonin on human mood and performance
18. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone
19. Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin-4
20. Hematopoietic rescue via T-cell-dependent endogenous GM-CSF by the pineal neurohormone melatonin in tumor bearing mice
21. T-helper 2 lymphocytes as peripheral target of melatonin signaling
22. Melatonin and its precursors scavenger nitric oxide
23. Interleukins and interferons
24. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin
25. Immune response of rats after pharmacologic pinealectomy
26. Changes in serotonin levels, N-acetyltransferase activity, hydroxyindole-o-methyltransferase activity, and melatonin levels in the pineal gland of the Richardson's ground squirrel in relation to the light-dark cycle
27. Melatonin as a free radical scavenger: Implications for aging and age-related diseases
28. A review of the evidence supporting melatonin's role as an antioxidant
29. Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: Suppression by dexamethasone
30. Early expression of IFN-alpha/beta and iNOS in the brains of Venezuelan equine encephalitis virus-infected mice
31. Interleukin-2: Inception, impact and implication
32. Dexamethasone and 1,25-dihydroxy-vitamin D3, but not cyclosporine A, inhibit production of granulocyte-macrophage colony-stimulating factor in human fibroblasts
33. Dexamethasone inhibits prolonged survival and autocrine granulocyte-macrophage colony-stimulating factor production by human eosinophils cultured on laminin or tissue fibronectin
34. Haemopoietic colony stimulating factor promotes cell survival by suppressing apoptosis