Molecular basis of T cell-mediated recognition of pancreatic cancer cells

Cancer Research

Volumn 61, Issue 5, 2001, Pages 2038-2046

  Ito, M ^a   Shichijo, S ^a   Tsuda, N ^a   Ochi, M ^a   Harashima, N ^a   Saito, N ^a   Itoh, K ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A2 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOTHERAPY; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; CRICETINAE; EPITOPES, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; INTERFERON TYPE II; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PANCREATIC NEOPLASMS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0035266335     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Cancer of the pancreas
2. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
3. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
4. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes
5. Multiple specificities in the repertoire of a melanoma patient's cytolytic T lymphocytes directed against tumor antigen MAGE-1.A1
6. A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma
7. A CASP-8 mutation recognized by cytotoxic T lymphocytes on a human head and neck carcinoma
8. A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes
9. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-24-restricted cytotoxic T lymphocyte in cancer patients
10. A cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
11. Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3
12. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
13. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
14. Anti-MUCI antibodies react directly with MUCI peptides presented by class I H2 and HLA molecules
15. Towards immunotherapy of pancreatic cancer
16. Polyclonal uses of T-cell receptor (TCR) α and β genes for cytotoxic T lymphocytes in human metastatic melanoma: Possible involvement of TCRα in tumor-cell recognition
17. MHC ligands and peptide motifs: First listing
18. In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein
19. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts
20. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L.
21. Comparative analysis of a novel gene from the Wolf- Hirschhorn/Pitt-Rogers-Danks syndrome critical region
22. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
23. The 100-kDa 2′,5′-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2′ p5′A molecules is composed of three homologous domains
24. The outline structure of the T-cell αβ receptor
25. Predominant expression of T cell receptor Vα in tumor-infiltrating lymphocytes of uveal melanomas
26. T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: Tumor infiltrating lymphocytes overexpress in vivo the TCRβ chain sequence used by HLA-A2-restricted and melanocyte-lineage specific CTL clones
27. Analysis of T-cell receptor α/β variability in lymphocytes infiltrating a melanoma metastasis
28. Two autologous melanoma-specific and MHC-restricted human T cell clones with identical intra-tumor reactivity do not share the same TCR Vα and Vβ gene families
29. MAP kinase by any other name smells just as sweet
30. Mutated mitogen-activated protein kinase: A tumor rejection antigen of mouse sarcoma
31. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
32. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
33. A new family of 10 murine ovalbumin serpins induces two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
34. Cancer of the colon
35. Colon cancer
36. Allele and haprotype frequencies for HLA and complement loci in various ethnic groups
37. Genetic diversity of HLA-A2: Evolutionary and functional significance