Biocompatibility and biodegradation of intravitreal hyaluronan implants in rabbits

Biomaterials

Volumn 22, Issue 3, 2001, Pages 195-200

  Avitabile, Teresio ^a   Marano, Filippo ^a   Castiglione, Francesco ^a   Bucolo, Claudio ^b   Cro, Melina ^b   Ambrosio, Luigi ^c   Ferrauto, Carmelo ^a   Reibaldi, Alfredo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b Fidia Oftal Research Laboratories   (Italy)

^c CNR   (Italy)

Author keywords

Biocompatibility; Biodegradation; Hyaluronan esters; Scleral implant; Ultrasound biomicroscopy

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; CONTROLLED DRUG DELIVERY; ESTERS; MICROSCOPIC EXAMINATION; PHYSIOLOGICAL MODELS; ULTRASONIC IMAGING;

HYALURONAN ESTERS; SCLERAL IMPLANTS; ULTRASOUND BIOMICROSCOPY;

IMPLANTS (SURGICAL);

HYAFF11; HYAFF11P75; HYAFF7; HYALURONIC ACID DERIVATIVE; HYALURONIC ACID ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; BIODEGRADATION; BIOMICROSCOPY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISSOLUTION; DRUG DELIVERY SYSTEM; ELECTRORETINOGRAM; EYE; HISTOLOGY; IMPLANT; MALE; MICROSCOPY; NONHUMAN; OPHTHALMOSCOPY; PRIORITY JOURNAL; RABBIT; SCLEROTOMY; SLIT LAMP; STATISTICAL ANALYSIS; ULTRASOUND; VARIANCE; VITREOUS BODY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; DRUG IMPLANTS; HYALURONIC ACID; MALE; RABBITS; VITREOUS BODY;

ORYCTOLAGUS CUNICULUS;

EID: 0035255910     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(00)00169-1     Document Type: Article

References (20)

1. Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis; Use of an intravitreal device
2. An intravitreal device providing sustained release of cyclosporine and dexamethasone
3. Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy
4. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. Ganciclovir Implant Study Group
5. Biodegradable scleral implant for intravitreal controlled release of fluconazole
6. A new vitreal drug delivery system using an implantable biodegradable polymeric device
7. Biodegradable polymeric device for sustained intravitreal release of ganciclovir in rabbits
8. Hyaluronic esters a new class of semisynthetic biopolymer: chemical and physical properties
9. Experimental measurement of intravitreal inserts with echography
10. Measurement of ultrasound biomicroscopy images; intraobserver and interobserver reliability
11. Liposome-encapsulated 5-fluorouracil in the treatment of proliferative vitreoretinopathy
12. Intravitreal liposome-encapsulated gentamycin in a rabbit model
13. Biodegradable microspheres containing adriamycin in treatment of proliferative vitreoretinopathy
14. Intravireal liposome-encapsulated drugs; a preliminary human report
15. Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil
16. In vitro studies of biocompatibility of hyaluronic acid esters
17. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats
18. Quantitative assessment of the tissue response to films of hyaluronan derivatives
19. Methylprednisolone esters of hyaluronic acid in ophthalmic drug delivery; in vitro and in vivo release studies
20. Biodegradation of hyaluronic acid derivatives by hyaluronidase