A protein dissection study demonstrates that two specific hydrophobic clusters play a key role in stabilizing the core structure of the molten globule state of human α-lactalbumin

Proteins: Structure, Function and Genetics

Volumn 42, Issue 2, 2001, Pages 237-242

  Demarest, Stephen J ^a   Horng, Jia Cherng ^a   Raleigh, Daniel P ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

lactalbumin; Denatured state; Hydrophobic interactions; Molten globule; Protein folding

Indexed keywords

ALPHA LACTALBUMIN;

ALPHA HELIX; CONFERENCE PAPER; CROSS LINKING; HYDROPHOBICITY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; HUMANS; LACTALBUMIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING;

EID: 0035254984     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20010201)42:2<237::AID-PROT110>3.0.CO;2-B     Document Type: Conference Paper

References (24)

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12. Defining the critical core of the α-lactalbumin molten globule state
13. Local interactions and the role of the 6-120 disulfide bond in α-lactalbumin: Implications for formation of the molten globule state
14. Solution structure of a peptide model of a region important for the folding of α-lactalbumin provides evidence for the formation of non-native structure in the denatured state
15. Local interactions drive the formation of non-native structure in the denatured state of human α-lactalbumin: A high resolution structural characterization of a peptide model in aqueous solution
16. Crystal structure of human α-lactalbumin at 1.7 Å resolution
17. Residue depth: A novel parameter for the analysis of protein structure and stability
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19. How to measure the molar absorption coefficient of a protein
20. Determination and analysis of urea and guanidine hydrochloride denaturation curves
21. Native-like secondary structure in a peptide from the α-domain of hen lysozyme
22. A specific hydrophobic core in the α-lactalbumin molten globule
23. Contribution of individual residues to formation of the native-like topology in the α-lactalbumin molten globule
24. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures