Local interactions drive the formation of nonnative structure in the denatured state of human α-lactalbumin: A high resolution structural characterization of a peptide model in aqueous solution

Biochemistry

Volumn 38, Issue 22, 1999, Pages 7380-7387

  Demarest, Stephen J ^a   Hua, Yuxin ^a   Raleigh, Daniel P ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LACTALBUMIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDROPHOBICITY; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN STRUCTURE;

CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HUMANS; LACTALBUMIN; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN DENATURATION; SOLUTIONS; THERMODYNAMICS; TRIFLUOROETHANOL; WATER;

EID: 0033153245     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990320z     Document Type: Article

References (32)

1. Dyson H. J., and Wright, P. E. (1996) Annu. Rev. Phys. Chem. 47, 369-395.
2. Wüthrich, K. (1994) Curr. Opin. Struct. Biol. 4, 93-99.
3. Rothwarf, D. M., and Scheraga, H. A. (1996) Biochemistry 35, 13797-13807.
4. Kiefhaber, T., Grunert, H.-P., Hahn, U., and Schmid, F. X. (1992) Proteins: Struct., Funct., Genet. 12, 171-179.
5. Sosnick, T. R., Mayne, L., Hiller, R., and Englander, S. W. (1994) Nat. Struct. Biol. 1, 149-156.
6. Neri, D., Billeter, M., Wider, G., and Wüthrich, K. (1992) Science 257, 1559-1563.
7. Acharya, K. R., Ren, J., Stuart, D. I., Phillips, D. C., and Fenna, R. E. (1991) J. Mol. Biol. 221, 571-581.
8. Harata, K., and Muraki, M. (1992) J. Biol. Chem. 267, 1419-1421.
9. Schulman, B. A., and Kim, P. S. (1996) Nat. Struct. Biol. 3, 682-687.
10. Demarest, S. J., Fairman, R., and Raleigh, D. P. (1998) J. Mol. Biol. 283, 279-291.
11. Alexandrescu, A. T., Evans, P. A., Pitkeathly, M., Baum, J., and Dobson, C. M. (1993) Biochemistry 32, 1707-1718.
12. Smith, L. J., Alexandrescu, A. T., Pitkeathly, M., and Dobson, C. M. (1995) Structure 2, 703-712.
13. Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., and Gray, T. (1995) Protein Sci. 4, 2411-2423.
14. Marion, D., and Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 113, 967-914.
15. States, D. J., Haberkorn, R. A., and Ruben, D. J. (1982) J. Magn. Reson. 48, 286-292.
16. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, Inc., New York.
17. Kim, Y., and Prestegard, J. H. (1989) J. Magn. Reson. 84, 9-13.
18. Griesinger, C., Sørenson, O. W., and Ernst, R. R. (1987) J. Magn. Reson. 75, 474-492.
19. Griesinger, C., and Ernst, R. R. (1987) J. Magn. Reson. 75, 261-271.
20. Wagner, G., Braun, W., Havel, T. F., Schaumann, T., Gó, N., and Wüthrich, K. (1987) J. Mol. Biol. 196, 611-639.
21. Brünger, A. T. (1992) X-PLOR version 3.1. A system for X-ray crystallography and NMR, Yale University Press, New Haven, CT.
22. Nilges, M., Gronenborn, A. M., Brünger, A. T., and Clore, G. M. (1988) Protein Eng. 2, 27-38.
23. Nilges, M., Clore, G. M., and Gronenborn, A. M. FEBS Lett. 239, 129-136 (1988).
24. Nilges, M., Kuszewski, J., and Brünger, A. T. (1991) Computational Aspects of the Study of Biological Macromolecules by NMR, Plenum Press, New York.
25. Kuszewski, J., Nilges, M., and Brünger, A. T. (1992) J. Biol. NMR 2, 33-56.
26. Nilges, M., Clore, G. M., and Gronenborn, A. M. (1988) FEBS Lett. 229, 317-324.
27. Herzberg, O., and Moult, J. (1991) Proteins: Struct., Funct., Genet. 11, 223-229.
28. Bolin, K. A., Pitkeathly, M., Miranker, A., Smith, L. J., and Dobson, C. M. (1996) J. Mol. Biol. 261, 443-453.
29. Ramírez-Alvarado, M., Blanco, F. J., and Serrano, L. (1996) Nat. Struct. Biol. 3, 612.
30. Blandamer, M. J., Burgess, J., Cooney, A., Cowles, H. J., Horn, I. H., Martin, K. J., Morcom, K. W., and Warrick, P. (1990) J. Chem. Soc., Faraday Trans. 86, 2209-2213.
31. Cammers-Goodwin, A., Allen, T. J., Oslick, S. L., McClure, K. F., Lee, J. H., and Kemp, D. S. (1996) J. Am. Chem. Soc. 118, 3082-3090.
32. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.