Calculation of the hydrophobicity of platinum drugs

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 472-474

  Platts, J A ^a   Hibbs, D E ^b   Hambley, T W ^b   Hall, M D ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; PLATINUM DERIVATIVE;

ACCURACY; ANALYTIC METHOD; ARTICLE; HYDROPHOBICITY; PREDICTION; REGRESSION ANALYSIS;

ANTINEOPLASTIC AGENTS; MODELS, CHEMICAL; ORGANOPLATINUM COMPOUNDS; QUANTUM THEORY; REGRESSION ANALYSIS; SOLUBILITY;

EID: 0035254864     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001080k     Document Type: Article

References (20)

1. Platinum compounds: A new class of potent antitumour agents
2. Current status of platinum-based antitumor drugs
3. Structure-activity relationships of the antitumor platinum coordination complexes
4. Mini-review: Discovery and development of platinum complexes designed to circumvent cisplatin resistance
5. Modifying the properties of platinum(IV) complexes in order to increase biological effectiveness
6. Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: Circumvention studies using novel platinum(II) and (IV) ammine/amine complexes
7. The influence of structure on the activity and toxicity of Pt anti-cancer drugs
8. Structure and activity relationships of platinum complexes with anti-tumour activity
9. Some aspects of platinum complex chemistry and their relation to antitumor activity
10. Stucture, activity, reactivity and solubility relationships of platinum diamine complexes
11. Hydrophobicity parameters for platinum complexes
12. Orally active DACH-Pt(IV) compounds
13. Relationship between hydrophobicity, reactivity, accumulation, and peripheral nerve toxicity of a series of platinum drugs
14. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena 1. Prediction of intestinal absorption
15. Comprehensive Ab initio quantum mechanical and Molecular Orbital (MO) analysis of cisplatin: Structure, bonding, charge density, and vibrational frequencies
16. Ab initio effective core potentials for molecular calculations - Potentials for the transition metal atoms Sc-Hg
17. Analytical treatment of the volume and surface area of molecules formed by an arbitrary collection of unequal spheres intersected by planes
18. Hydrogen bonding. 32. An analysis of water-alkane and water-octanol partitioning and the Δlog parameter of seller