Inorganic iron complexes derived from the nitric oxide donor nitroprusside: Competitive N-methyl-D-aspartate receptor antagonists with nanomolar affinity

Biochemical Pharmacology

Volumn 61, Issue 3, 2001, Pages 343-349

  Neijt, Hans ^a   Koller, Manuel ^a   Urwyler, Stephan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Inorganic metal complexes; Iron complexes; Nitroprusside; NMDA receptor

Indexed keywords

2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; ALPHA ADRENERGIC RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINOPENTACYANOFERRATE; AQUAPENTACYANOFERRATE; DIZOCILPINE; DOPAMINE RECEPTOR; IRON COMPLEX; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE; NITROPRUSSIDE SODIUM; OPIATE RECEPTOR; SEROTONIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DEPOLARIZATION; DRUG EFFECT; DRUG POTENCY; ION EXCHANGE CHROMATOGRAPHY; PHOTODEGRADATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RADIOASSAY;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BINDING, COMPETITIVE; EXCITATORY AMINO ACID ANTAGONISTS; FERROCYANIDES; IRON COMPOUNDS; NITRIC OXIDE DONORS; NITROPRUSSIDE; RADIOLIGAND ASSAY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TRITIUM;

EID: 0035254210     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00566-9     Document Type: Article

References (40)

1. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
2. 3H]glutamate binding to rat brain synaptic membranes
3. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
4. Nitric oxide-induced blockade of NMDA receptors
5. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
6. Sodium nitroprusside selectively blocks the N-methyl-D-aspartate response in rat cerebral cortex: An effect of nitric oxide?
7. Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside
8. Inhibition of glutamate-induced cell death by sodium nitroprusside is not mediated by nitric oxide
9. 2+ elevation
10. 3H]MK-801 binding by ferrous (II) but not ferric (III) ions in a manner different from that by sodium nitroprusside (II) in rat brain synaptic membranes
11. Photochemistry of pentacyanonitrosylferrate(2-), nitroprusside
12. Spectrophotometric determination of sodium nitroprusside and its photodegradation products
13. Photodegradation of sodium nitroprusside: Biologic activity and cyanide release
14. Excited state chemistry of the ferrocyanide ion in aqueous solution. II. Photoaquation
15. The photolysis of aqueous solutions of potassium hexacyanoferrate(III)
16. Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists. 1. Pharmacological characterization in vitro
17. 3H]CGP 39653: A new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain
18. 3H]glycine to its strychnine-insensitive recognition site associated with the N-methyl-D-aspartate receptor complex
19. Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors
20. 3H-prazosin to rat brain α-adrenergic receptors
21. 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum
22. 3H-(-)-sulperide to dopamine D2 receptors in rat striatal membranes: Methodological considerations and demonstration of the identical nature of the binding sites for the two ligands
23. 3H]ketanserin
24. 1D binding sites in various species: Similar pharmacological profile in dog, monkey, calf, guinea-pig and human brain membranes
25. Opiate receptor: Demonstration in nervous tissue
26. 50) of an enzymatic reaction
27. Some quantitative uses of drug antagonists
28. Quantitative studies on some antagonists of N-methyl-D-aspartate in slices of rat cerebral cortex
29. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: Effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801
30. Ueber Eisenpentacyanverbindungen
31. 3H]dibenzocycloalkenimine [MK-801] to the N-methyl-D-aspartate (NMDA) receptor and its therapeutic implication
32. The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro
33. Etude sur les pentacyanoamine-ferroates
34. Substitution reactions of Di-μ-cyano-bis[tetracyanoferrate(II)] in aqueous solution
35. Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit
36. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors
37. Recent advances in excitatory amino acid research
38. Kinetics of formation and stability constants of some pentacyanoferrate(II) complexes of aromatic nitrogen heterocycles
39. Nitric oxide-independent inhibition by sodium nitroprusside of the native N-methyl-D-aspartate recognition domain in a manner different from that by potassium ferrocyanide