Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients

Journal of Neural Transmission, Supplement

Volumn , Issue 61, 2001, Pages 1-9

  Kim, S H ^a   Lubec, G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA ENDOSULFINE; NEUROTRANSMITTER; POTASSIUM CHANNEL; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ENDOSULFINE; INWARD RECTIFIER POTASSIUM CHANNEL; PEPTIDE;

ALZHEIMER DISEASE; ARTICLE; CEREBELLUM; COGNITION; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; WESTERN BLOTTING; ADULT; AGED; CHEMISTRY; FRONTAL LOBE; INWARDLY RECTIFYING POTASSIUM CHANNEL; METABOLISM; PROTEIN QUATERNARY STRUCTURE;

AGED; BLOTTING, WESTERN; CEREBELLUM; DOWN SYNDROME; FEMALE; FRONTAL LOBE; HUMAN; MALE; MIDDLE AGE; PEPTIDES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, QUATERNARY; SUPPORT, NON-U.S. GOV'T;

EID: 0035232355     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6262-0_1     Document Type: Article

References (41)

1. rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA (1995) Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268: 423-426
2. + channels. Science 247: 852-854
3. th, Kunjilwar K, Gonzalez G, Schwantstecher M, Panten U, Aguilar-Bryan L, Bryan J (1997) Association and stoichiometry of K(ATP) channel subunits. Neuron 18: 827-838
4. + channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons. J Neurophysiol 69: 494-503
5. During MJ, Leone P, Davis KE, Kerr D, Sherwin RS (1995) Glucose modulates rat substantia nigra GABA release in vivo via ATP-ensitive potassium channels. J Clin Invest 95: 2403-2408
6. Edwards G, Weston AH (1993) The pharmacology of ATP-sensitive potassium channels. Ann Rev Pharmacol Toxicol 33: 597-637
7. Fiedler JL, Epstein CJ, Rapoport SI, Caviedes R, Caviedes P (1994) Regional alteration of cholingeric function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). Brain Res 658: 27-32
8. Godridge H, Reynolds GP, Czudek C, Calcutt NA, Benton M (1987) Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue. J Neurol Neurosurg Psychiatry 50: 775-778
9. Gold PE (1995) Role of glucose in regulating the brain and cognition. Am J Clin Nutr [Suppl] 61: 987S-995S
10. A synaptic potentials in rat midbrain dopamine neurons. Acta Physiol Scand 156: 147-148
11. Haj-Dahmans S, Laporte AM, Vantalon V, Fattaccini CM, Hamon M, Lanfumey L (1993) Possible involvement of K(ATP) channels in the control of 5-HT neurons. Brain Res 614: 270-278
12. ATP channel: molecular cloning, expression and biological properties. Proc Natl Acad Sci USA 95: 8387-8391
13. Heron L, Virsolvy A, Apiou F, Le Cam A, Bataille D (1999) Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels. Diabetes 48: 1873-1876
14. th, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J (1995) Reconstitution of IKATP: an inward rectifier subunit plus sulfonylurea receptor. Science 270: 1166-1170
15. 3H] Vesamicol binding in human brain cholinergic deficiency disorders. Neurosci Lett 117: 347-352
16. Korol DL, Gold PE (1998) Glucose, memory, and aging. Am J Clin Nutr [Suppl] 67: 764S-771S
17. + currents recorded from an insulin-secreting cell line. Br J Pharmacol 97: 1039-1050
18. Labudova O, Cairns N, Kitzmuller E, Lubec G (1999) Impaired brain glucose metabolism in patients with Down syndrome. J Neural Transm [Suppl] 57: 247-256
19. Lazdunski M (1996) Ion channel effects of antidiabetic sulfonylureas. Horm Metab Res 28: 488-495
20. Lauritzen I, De Weille JR, Lazdunski M (1997) The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons. J Neurochem 69: 1570-1579
21. Lee K, Brownhill V, Richardson PJ (1997) Antidiabetic sulphonylureas stimulate acetylcholine release from striatal cholinergic interneruons through inhibition of K(ATP) channel activity. J Neurochem 69: 1774-1776
22. Lopez L, Sannita WG (1997) Glucose availability and the electrophysiology of the human visual system. Clin Neurosci 4: 336-340
23. Mann DM, Yates PO, Marcyniuk B, Ravindra CR (1985) Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J Ment Defic Res 29: 125-135
24. Miller RJ (1990) Glucose-regulated potassium channels are sweet news for neurobiologists. Trends Neurosci 13: 197-199
25. + channels in the central nervous system: autoradiographic analysis of their distribution and ontogenesis, and of their localization in mutant mice cerebellum. Brain Res 519: 29-43
26. + channels both post-synpatically and on mossy fibers. Brain Res 540: 340-344
27. Peyrollier K, Heron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996) Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins. Biochem Biophys Res Commun 223: 583-586
28. Quast U (1992) Potassium channel openers: pharmacological and clinical aspects. Fundam Clin Pharmacol 6: 279-293
29. Reynolds GP, Godridge H (1985) Alzheimer-like brain monoamie deficits in adults with Down's syndrome. Lancet ii: 1368-1369
30. Reynolds GP, Warner CE (1988) Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue. Neurosci Lett 94: 224-227
31. Sakuta H (1995) ATP-sensitive potassium channel and hormone/neuropeptide. Nippon Naibunpi Gakkai Zasshi 71: 579-586
32. Sakura H, Ammala C, Smith PA, Gribble FM, Ashcroft FM (1995) Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channels subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett 377: 338-344
33. Schapiro MB, Haxby JV, Grady CL (1992) Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiol Aging 13: 723-734
34. + channel in insulin-secreting cells. J Biol Chem 262: 15840-15844
35. + channel with an ABC transporter. Neuron 26: 155-167
36. ATP channel complex. J Gen Physiol 110: 655-664
37. + channel. Lancet ii: 474-475
38. + channels in the absence of the sulfonylurea receptor. Nature 387: 179-183
39. Virsolvy-Vergine A, Leray H, Kuroki S, Lupo B, Dufour M, Bataille D (1992) Endosulfine, an endogenous peptidic ligand for the sulfonylurea receptor: purification and partial characterization from ovine brain. Proc Natl Acad Sci USA 89: 6629-6633
40. Virsolvy-Vergine A, Salazar G, Sillard R, Denoroy L, Mutt V, Bataille D (1996) Endosulfine, endogenous ligand for the sulfonylurea receptor: isolation from porcine brain and partial structural determination of the alpha form. Diabetologia 39: 135-141
41. Yates CM, Simpson J, Gordon A, Maloney AF, Allison Y, Ritchie IM, Urquhart A (1983) Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res 280: 119-126