Use of western immunoblot for evaluation of myocardial dystrophin, α-sarcoglycan, and β-dystroglycan in dogs with idiopathic dilated cardiomyopathy

American Journal of Veterinary Research

Volumn 62, Issue 1, 2001, Pages 67-71

  Spier, Alan W ^a   Meurs, Kathryn M ^a   Coovert, Daniel D ^b   Lehmkuhl, Linda B ^a,f   O'Grady, Michael R ^c   Freeman, Lisa M ^d   Burghes, Arthur H ^b   Towbin, Jeffrey A ^e  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF GUELPH   (Canada)

^d TUFTS UNIVERSITY   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f MedVet Veterinary Specialists   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS;

CYTOSKELETON PROTEIN; DYSTROGLYCAN; DYSTROPHIN; LAMININ RECEPTOR; MEMBRANE PROTEIN; SARCOGLYCAN;

ANIMAL; ANIMAL DISEASE; ANIMAL MUSCULAR DYSTROPHY; ARTICLE; CHEMISTRY; CONGESTIVE CARDIOMYOPATHY; DOG; DOG DISEASE; DUCHENNE MUSCULAR DYSTROPHY; HEART MUSCLE; METABOLISM; REFERENCE VALUE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARDIOMYOPATHY, DILATED; CYTOSKELETAL PROTEINS; DOG DISEASES; DOGS; DYSTROGLYCANS; DYSTROPHIN; MEMBRANE GLYCOPROTEINS; MUSCULAR DYSTROPHY, ANIMAL; MUSCULAR DYSTROPHY, DUCHENNE; MYOCARDIUM; RECEPTORS, LAMININ; REFERENCE VALUES; SARCOGLYCANS;

EID: 0035220363     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2001.62.67     Document Type: Article

References (36)

1. Kasper EK, Agema WRP, Hutchins GM, et al. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 patients. J Am Coll Cardiol 1994;23:586-590.
2. Koga Y, Ogata M, Kihara K, et al. Sudden death in hypertrophic and dilated cardiomyopathy. Jpn Circ J 1989;53:1546-1556.
3. Calvert CA, Chapman WL, Toal RL. Congestive cardiomyopathy in Doberman Pinscher dogs. J Am Vet Med Assoc 1982;181:598-602.
4. Harpster N. Boxer cardiomyopathy. Vet Clin North Am Small Anim Pract 1991;21:989-1004.
5. Freeman LM, Michel KE, Brown DJ, et al. Idiopathic dilated cardiomyopathy in Dalmations: nine cases (1990-1995). J Am Vet Med Assoc 1996;209:1592-1596.
6. Kittleson MD, Keene B, Pion PD, et al. Results of the multi-center spaniel trial (MUST): taurine- and carnitine-responsive dilated cardiomyopathy in American Cocker Spaniels with decreased plasma taurine concentration. J Vet Intern Med 1997;11:204-211.
7. Gooding JP, Robinson WF, Wybura RS, et al. A cardiomyopathy in the English Cocker Spaniel: a clinico-pathological investigation. J Small Anim Pract 1982;23:133-149.
8. Sisson DD, Thomas WP. Myocardial diseases. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 4th ed. Philadelphia: WB Saunders Co, 1995;996-1005.
9. Pion P, Kittleson MD, Rogers QR, et al. Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science 1987;237:764-768.
10. Eschenhagen T, Diederich M, Kluge S, et al. Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy. J Mol Cell Cardiol 1995;27:357-370.
11. Muntoni F, Wilson L, Marrosu G, et al. A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart. J Clin Invest 1995;96:693-699.
12. Towbin JA, Hejtmancik F, Brink P, et al. X-linked dilated cardiomyopathy: molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. Circulation 1993;87:1854-1865.
13. Ortiz-Lopez R, Li H, Su J, et al. Evidence for a dystrophin missense mutation as a cause of X-linked dilated cardiomyopathy. Circulation 1997;95:2434-2440.
14. Yoshida K, Ikeda S, Nakamura A, et al. Molecular analysis of the Duchenne muscular dystophy gene in patients with Becker muscular dystrophy presenting with dilated cardiomyopathy. Muscle Nerve 1993;16:1161-1166.
15. Moise NS, Valentine BA, Brown CA, et al. Duchenne's cardiomyopathy in a canine model: electrocardiographic and echocardiographic studies. J Am Coll Cardiol 1991;17:812-820.
16. Sharp NJH, Kornegay JN, van Camp SD, et al. An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy. Genomics 1992;13:115-121.
17. Sapp JL, Bobet J, Howlett SE. Contractile properties of myocardium are altered in dystrophin-deficient mdx mice. J Neurol Sci 1996;142:17-24.
18. Fadic R, Sunada Y, Waclawik AJ, et al. Brief report: deficiency of a dystrophin-associated glycoprotein (adhalin) in a patient with muscular dystrophy and cardiomyopathy. N Engl J Med 1998;334:362-366.
19. Bies RD, Maeda M, Roberds SL, et al. A 5' dystrophin duplication mutation causes membrane deficiency of α-dystroglycan in a family with X-linked cardiomyopathy. J Mol Cell Cardiol 1997;29:3175-3188.
20. Roberds SL, Ervasti JM, Anderson RD, et al. Disruption of the dystrophin-glycoprotein complex in the cardiomyopathic hamster. J Biol Chem 1993;268:11496-11499.
21. DiBlasi C, Morandi L, Barresi R, et al. Dystrophin-associated protein abnormalities in dystrophin-deficient muscle fibers from symptomatic and asymptomatic Duchenne/Becker muscular dystrophy carriers. Acta Neuropathol 1996;92:369-377.
22. Kittleson MD, Eyster GE, Knowlen GG, et al. Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure. J Am Vet Med Assoc 1984;184:455-459.
23. Bonagura JD, O'Grady MR, Herring DS. Echocardiography: principles of interpretation. Vet Clin North Am Small Anim Pract 1985;15:1177-1194.
24. Burrow KL, Coovert DD, Klein CJ, et al. Dystrophin expression and somatic reversion in prednisone-treated and untreated Duchenne dystrophy. Neurology 1991;41:661-666.
25. Coovert DD, McAndrew PE, Strasswimmer J, et al. The survival motor neuron protein in spinal muscular atrophy. Hum Mol Genet 1997;6:1205-1214.
26. Le TT, Man NT, Love DR, et al. Monoclonal antibodies against the muscle specific N-terminus of dystrophin: characterization of dystrophin in a muscular dystrophy patient with a frameshift deletion of exons 3-7. Am J Hum Genet 1993;53:131-139.
27. Bulman DE, Murphy GE, Zubrzycka-Gaarn EE, et al. Differentiation of Duchenne and Becker muscular dystrophyphenotypes with amino- and carboxyl-terminal antisera specific for dystrophin. Am J Hum Genet 1991;48:295-304.
28. Mestroni L, Krajinovic M, Severini GM, et al. Molecular genetics of dialled cardiomyopathies. Eur Heart J 1995;16:5-9.
29. Towbin JA. The role of cytoskeletal proteins in cardiomyopathies. Curr Opin Cell Biol 1998;10:131-139.
30. Keene B, Panciera DP, Atkins CE, et al. Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 1991;198:647-650.
31. Goodwin JK, Cattiny G. Further characterization of Boxer cardiomyopathy, in Proceedings. 13th Annu Meet Vet Med Forum 1996;300-302.
32. Meurs KM, Spier AW, Miller MW, et al. Familial ventricular arrhythmias in Boxers. J Vet Intern Med 1999;13:437-439.
33. van der Kooi AJ, de Voogt WG, Barth PG, et al. The heart in limb girdle muscular dystrophy. Heart 1998;79:73-77.
34. Salih MAM, Sunada Y, Al-Nasser M, et al. Muscular dystrophy associated with β-dystroglycan deficiency. Ann Neurol 1996;40: 925-928.
35. Montanaro F, Carbonetto S, Campbell KP, et al. Dystroglycan expression in the wild type and mdx mouse neural retina: synaptic colocalization with dystrophin, dystrophin-related protein but not laminin. J Neurosci Res 1995;42:528-538.
36. Ervasti JM, Ohlendieck K, Kahl SD, et al. Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle. Nature 1990;345:315-319.