Is mixed effects modeling or naive pooled data analysis preferred for the interpretation of single sample per subject toxicokinetic data?

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 2, 2001, Pages 193-210

  Hing, J P ^a   Woolfrey, S G ^a   Greenslade, D ^a   Wright, P M C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Computer simulations; Destructive sampling; Mixed effects model; Research study design; Toxicokinetics

Indexed keywords

ANTIARRHYTHMIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DATA ANALYSIS; DRUG RESEARCH; ERROR; FEMALE; INTERMETHOD COMPARISON; MALE; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT; SAMPLING; TOXICOKINETICS;

ANIMALS; DATA INTERPRETATION, STATISTICAL; MODELS, BIOLOGICAL; PHARMACOKINETICS; RATS; SAMPLE SIZE;

EID: 0034759888     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011507100493     Document Type: Article

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