Intranasal absorption of sumatriptan and naratriptan: No evidence of local transfer from the nasal cavities to the brain arterial blood in male rats

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 5, 2001, Pages 213-219

  Einer Jensen, Niels ^a   Larsen, Lise ^a   Deprez, Stephanie ^b   Starns, Elaine ^b   Schwartz, Sheila ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Absorption; Cavernous sinus carotid artery complex; Naratriptan; Sumatriptan

Indexed keywords

ANTIMIGRAINE AGENT; NARATRIPTAN; PROPANOL; SEROTONIN 1B AGONIST; SEROTONIN 1D AGONIST; SUMATRIPTAN; TYROSINE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CATHETER; ARTICLE; BRAIN BLOOD FLOW; CAROTID ARTERY; CAVERNOUS SINUS; CONTROLLED STUDY; COUNTERCURRENT SYSTEM; DOSE RESPONSE; DRUG ABSORPTION; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG TRANSPORT; MALE; NONHUMAN; NOSE CAVITY; RAT; SYSTEMIC CIRCULATION; TIME;

ABSORPTION; ANIMALS; CEREBRAL ARTERIES; INDOLES; MALE; NASAL CAVITY; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SUMATRIPTAN; TRYPTAMINES;

EID: 0035214620     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.281     Document Type: Article

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