Naratriptan: Biological profile in animal models relevant to migraine

Cephalalgia

Volumn 17, Issue 3, 1997, Pages 145-152

  Connor, H E ^a   Feniuk, W ^c   Beattie, D T ^a   North, P C ^a   Oxford, A W ^a   Saynor, D A ^b   Humphrey, P P A ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b University of Cambridge ^*  (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KETANSERIN; METITEPINE; NARATRIPTAN; SEROTONIN; SUMATRIPTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; FEMALE; HEADACHE; INTRATHECAL DRUG ADMINISTRATION; MALE; MIGRAINE; NONHUMAN; ORAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION; VASOCONSTRICTION;

ANIMALS; BASILAR ARTERY; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INDOLES; MALE; MICE; MUSCLE CONTRACTION; PIPERIDINES; RATS; SUMATRIPTAN; TRYPTAMINES;

EID: 0030908742     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-2982.1997.1703145.x     Document Type: Article

References (28)

1. Tansey MJB, Pilgrim AJ, Lloyd K. Sumatriptan in the acute treatment of migraine. J Neurological Sci 1993;114:109-16
2. 1D receptor subtypes. Trends Pharmacol Sci 1996;17:103-5
3. 1Dβ. Proc Natl Acad Sci USA 1992;89:3630-4
4. 1-like receptor in dog isolated saphenous vein. Br J Pharmacol 1989;94:1123-32
5. 1-like receptor agonist. Br J Pharmacol. 1989;96:379-87
6. Feniuk W, Humphrey PPA, Perren MJ. The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol 1989;96:83-90
7. 1Dβ receptor subtype in human and bovine cerebral arteries. Mol Pharmacol 1993;44:242-6
8. Connor HE, Beattie DT. 5HT receptor subtypes and migraine. In: Sandler M, Ferrari M, Harnett S, editors. Migraine: pharmacology and genetics. London: Chapman and Hall, 1996:18-31
9. Buzzi MG, Moskowitz MA. The antimigraine drug sumatriptan (GR43175) selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br J Pharmacol 1990;99:202-6
10. Moskowitz MA. Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine. Trends Pharmacol Sci 1992;13:307-12
11. Humphrey PPA, Goadsby PJ. The mode of action of sumatriptan is vascular? A debate. Cephalalgia 1994;14:401-10
12. 1 receptor. Br J Pharmacol 1993;108:99P
13. 1 receptor agonist. Br J Pharmacol 1993;108:260P
14. Sambrook J, Fritsch EF, Maniatis MJ. Molecular cloning - a laboratory manual. Cold Spring Harbour Laboratory Press, 1989;3:1641-6
15. 1D-type receptor. Mol Pharmacol 1991;40:143-8
16. 1D-like pharmacological specificity. Biochem Biophys Res Commun 1992;184:752-9
17. 1 recognition sites. J Receptor Res 1988;8:59-81
18. 3 receptors in rat brain using radioligand binding. Nature 1987;30:746-8
19. Connor HE, Feniuk W. Influence of the endothelium on contractile effects of 5-hydroxytryptamine and selective 5HT agonists in canine basilar artery. Br J Pharmacol 1989;96:170-8
20. 2 receptor activation. Eur J Pharmacol 1989;161:91-4
21. 4 receptors in guinea-pig ascending colon. Eur J Pharmacol 1991;196:149-55
22. Sumner MJ, Feniuk W, Humphrey PPA. Further characterisation of the 5HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava. Br J Pharmacol 1989;97:292-300
23. Dixon CM, Saynor DA, Andrew PD, Oxford A, Bradbury A, Tarbit MH. Disposition of sumatriptan in laboratory animals and humans. Drug Metab Dis 1993;21:761-9
24. Perren MJ, Feniuk W, Humphrey PPA. The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175. Cephalalgia 1989;9 Suppl 9:41-6
25. Friberg L, Olesen J, Iverson HK, Sperling B. Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 1991;338:13-7
26. 1D receptor agonist, 311C90. In: Clifford Rose F, editor. New advances in headache research, vol 4. London: Smith Gordon Nishimura, 1994:3-4
27. Ferro A, Longmore J, Hill RG, Brown MJ. A comparison of the contractile effects of 5HT, sumatriptan and MK-462 on human coronary arteries in vitro. Br J Pharmacol 1995;114:162P
28. Skingle M, Birch PJ, Leighton GE, Humphrey PPA. Lack of antinociceptive activity of sumatriptan in rodents. Cephalalgia 1990;10:207-12