A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33

European Journal of Biochemistry

Volumn 268, Issue 23, 2001, Pages 6083-6096

  Whitney, Gena ^a   Wang, Shulin ^a   Chang, Han ^a   Cheng, Ke Yi ^a   Lu, Pin ^a   Zhou, Xia D ^a   Yang, Wen Pin ^a   McKinnon, Murray ^a   Longphre, Malinda ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

CD33; Inhibitory receptor; Phosphatase; Sialoadhesin; Siglec

Indexed keywords

CD33 ANTIGEN; CELL ADHESION MOLECULE; IMMUNOGLOBULIN; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RECEPTOR; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMOSOME 19Q; CHROMOSOME MAP; CONTROLLED STUDY; DATA BASE; GENE CLUSTER; GENOME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MOLECULAR LIBRARY; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BASE SEQUENCE; BINDING SITES; CELL LINE; CHROMOSOME MAPPING; DNA; GENE EXPRESSION; HUMANS; IMMUNE SYSTEM; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION;

EID: 0035214030     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02543.x     Document Type: Article

References (41)

1. The sialoadhesins - A family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily
2. Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis
3. Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains
4. Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues
5. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules
6. Sialoadhesin, myelin-associated glycoprotein and CD22 define a newfamily of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
7. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33
8. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta
9. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes
10. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily
11. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways
12. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes
13. Surface marker abnormalities in myelo-dysplastic syndromes
14. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
15. CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling
16. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells
17. Organization of the leukocyte receptor cluster (LRC) on human chromosome 19q13.4
18. Base-calling of automated sequencer traces using phred. I. Accuracy assessment
19. Base-calling of automated sequencer traces using phred. II. Error probabilities
20. Consed: A graphical tool for sequence finishing
21. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
22. Characterization of the mouse sialoadhesin gene Sn
23. Inflammation in asthma: The cornerstone of the disease and target of therapy
24. Pulmonary immune cells in health and disease: The eosinophil leukocyte (Part I)
25. T cells and eosinophils in asthma
26. The pathobiology of eosinophilic inflammation
27. Inhibitory pathways triggered by ITIM-containing receptors
28. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: Regulators of B cell signal transduction
29. A comprehensive genetic map of the human genome based on 5,264 microsatellites
30. Searching for asthma and atopy genes in the Hutterites: Genome-wide studies using linkage and association
31. The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells
32. Binding specificities of the sialoadhesin family of I-type lectins. Sialic acid linkage and substructure requirements for binding of myelin-associated glycoprotein, Schwann cell myelin protein, and sialoadhesin
33. The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22
34. Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22
35. Sialylation of the B lymphocyte molecule CD22 by alpha-2,6-sialyltransferase is implicated in the regulation of CD22-mediated adhesion
36. Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha-2,6-sialylation of adhesion molecules and CD22 ligands
37. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (siglec-2) on B lymphocytes
38. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily
39. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor
40. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)
41. The potential role of sialoadhesin as a macrophage recognition molecule in health and disease