Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: Characterization of the lys7 gene encoding saccharopine reductase

Journal of Bacteriology

Volumn 183, Issue 24, 2001, Pages 7165-7172

  Naranjo, L ^a   De Valmaseda, E M ^a   Banuelos O ^a   Lopez, P ^a   Riano J ^a   Casqueiro, J ^a   Martin, J F ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADIPIC ACID; CARBOXYLIC ACID DERIVATIVE; GENE PRODUCT; LYSINE; OXIDOREDUCTASE; PEPTIDE; PIPECOLATE OXIDASE; PIPECOLIC ACID; PIPERIDINE 6 CARBOXYLIC ACID; PROTEIN LYS1; PROTEIN LYS2; PROTEIN LYS3; SACCHAROPINE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; AUXOTROPHY; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGUS; FUNGUS GROWTH; GENE CLUSTER; GENE MUTATION; MAGNAPORTHE GRISEA; METABOLITE; NEUROSPORA CRASSA; NONHUMAN; PENICILLIUM CHRYSOGENUM; PLANT; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; LYSINE; MOLECULAR SEQUENCE DATA; MUTATION; OPEN READING FRAMES; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PENICILLIUM CHRYSOGENUM; PIPECOLIC ACIDS; PLASMIDS; SACCHAROPINE DEHYDROGENASES; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMATION, BACTERIAL;

EID: 0035212521     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.183.24.7165-7172.2001     Document Type: Article

References (44)

1. Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation and evolution
2. Conversion of α-aminoadipic acid to L-pipecolic acid by Aspergillus nidulans
3. Characterization and lysine control of the expression of the lys1 gene encoding homocitrate synthase
4. Overexpression of the lys1 gene in Penicillium chrysogenum: Homocitrate synthase levels, α-aminoadipic acid pool and penicillin production
5. The specific transport system for lysine is fully inhibited by ammonium in Penicillium chrysogenum: An ammonium-insensitive system allows uptake in carbon-starved cells
6. Subcellular localization of the homocitrate synthase in Penicillium chrysogenum
7. Two unlinked lysine genes (LYS9 and LYS14) are required for the synthesis of saccharopine reductase in Saccharomyces cerevisiae
8. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
9. Caracterization of High frequency transformation of Penicillium chrysogenum
10. Characterization of the lys2 gene of Penicillium chrysogenum encoding α-aminoadipic acid reductase
11. Intrachromosomal recombination between direct repeats in Penicillium chrysogenum: Gene conversion and deletion events
12. Gene targeting in Penicillium chrysogenum: Disruption of the lys2 gene leads to penicillin overproduction
13. Metabolic engineering of the lysine pathway for β-lactam overproduction in Penicillium chrysogenum
14. Induction of separate catabolic pathways for L- and D-lysine in Pseudomonas putida
15. L-pipecolic acid metabolism in human liver: L-α-aminoadipate-δ-semialdehyde oxidoreductase
16. L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases
17. Catabolism of lysine in Penicillium chrysogenum leads to formation of α-aminoadipic acid, a precursor of penicillin biosynthesis
18. 15N NMR study on D-lysine metabolism in Neurospora crassa
19. The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
20. Autonomously replicating plasmids carrying the AMAI region in Penicillium chrysogenum
21. Catabolism of L-lysine by Pseudomonas aeruginosa
22. Uptake and metabolism of α-aminoadipate by Penicillium chrysogenum
23. Regulation of the δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N biosynthesis in Penicillium chrysogenum by the α-aminoadipate pool size
24. Metabolism and compartmentation of α-aminoadipic acid in penicillin-producing strains of Penicillium chrysogenum
25. Cloning, expression, purification and crystallization of saccharopine reductase from Magnaporthe grisea
26. Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis
27. Lysine biosynthesis in Rhodotorula glutinis: Properties of pipecolic acid oxidase
28. Biosynthesis of lysine in Rhodotorula glutinis: Role of pipecolic acid
29. Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum
30. Changes in composition of conidia of Penicillium notatum during germination
31. Secondary metabolites
32. Purification and characterization of perixosomal L-pipecolic acid oxidase from monkey liver
33. Biosynthesis of the immunosuppressant immunomycin: The enzymology of pipecolate incorporation
34. Δ′-piperideine-2-carboxylate reductase of Pseudomonas putida
35. L-Pipecolic acid metabolism in human liver: Detection of L-pipecolic oxidase and identification of its reaction product
36. Assay for pipecolic acid oxidase activity in human liver: Detection of enzyme deficiency in hyperpipecolic acidaemia
37. L-pipecolic acid oxidation in rat: Subcellular localization and developmental study
38. Rapamycin, FK506, and ascomycin-related compounds
39. DNA sequencing with chain-terminating inhibitors
40. Transformation of Escherichia coli with larger DNA molecules by electroporation
41. Analysis of swainsonine and its early metabolic precursors in cultures of Metarhizium anisopliae
42. 1-piperideine-6-carboxylic acid pathway
43. Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: A unique flavine enzyme involved in pipecolic acid biosynthesis