DCPIB is a novel selective blocker of ICI,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration

British Journal of Pharmacology

Volumn 134, Issue 7, 2001, Pages 1467-1479

  Decher, Niels ^a   Lang, Hans J ^a   Nilius, Bernd ^b   Brüggemann, Andrea ^a   Busch, Andreas E ^a   Steinmeyer, Klaus ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Action potential; Atrium; DCPIB; Swelling activated chloride channel

Indexed keywords

4 (2 BUTYL 6,7 DICHLORO 2 CYCLOPENTYLINDAN 1 ON 5 YL)OXYBUTYRIC ACID; ETACRYNIC ACID; ION CHANNEL; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SWELLING; CHLORIDE CONDUCTANCE; CHLORIDE CURRENT; CONTROLLED STUDY; GUINEA PIG; HEART ATRIUM; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; MEMBRANE STEADY POTENTIAL; NONHUMAN; OOCYTE; OSMOTIC STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS LAEVIS;

EID: 0035210480     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704413     Document Type: Article

References (53)

1. Hypotonicity activates a native chloride current in Xenopus oocytes
2. Influence of potassium ions and osmolality on the resting membrane potential of rabbit ventricular papillary muscle with estimation of the activity and the activity coefficient of internal potassium
3. - currents in Xenopus follicles
4. Ion channels and membrane receptors in follicle-enclosed Xenopus oocytes
5. - channel activity in Xenopus oocytes expressing the cystic fibrosis gene
6. Inactivation of the sodium channel. I. Sodium current experiments
7. Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein
8. + current, on repolarization in human and guinea pig ventricular myocytes
9. Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative
10. sK channels expressed in Xenopus oocytes
11. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes
12. Regulation of cellular volume in rabbit ventricular myocytes: Bumetanide, chlorothiazide, and ouabain
13. Cardiac swelling-induced chloride current depolarizes canine atrial myocytes
14. Effects of hypertonic solution on action potential and input resistance in the guinea-pig ventricular muscle
15. Mutational analysis demonstrates that CLC-4 and CLC-5 directly mediate plasma membrane currents
16. Myocardial oedema: A preventable cause of reperfusion injury?
17. Stretch-activated anion currents of rabbit cardiac myocytes
18. Effects of stilbenedisulfonic acid derivatives on the cAMP-regulated chloride current in cardiac myocytes
19. Autonomic regulation of a chloride current in heart
20. Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias
21. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction
22. Myocardial ischemia revisited. The osmolar load, membrane damage, and reperfusion
23. + current by dofetilide
24. Effects of osmolarity change on the excitation-contraction coupling of bullfrog ventricle
25. Purification and reconstitution of chloride channels from kidney and trachea
26. Transmembrane chloride currents in human atrial myocytes
27. 2+ current by mechanical stimulation in single rabbit cardiac myocytes
28. Cardiac chloride channels: Physiology, pharmacology and approaches for cidentifying novel modulators of activity
29. Intracellular cyclic AMP inhibits native and recombinant volume-regulated chloride channels from mammalian heart
30. Activation of a Cl- current by hypotonic volume increase in human endothelial cells
31. Calcium-activated chloride channels in bovine pulmonary artery endothelial cells
32. Kinetic and pharmacological properties of the calcium-activated chloride current in macrovascular endothelial cells
33. - channel: Fresh start to the molecular identity and volume sensor
34. KATP
35. Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes
36. Length, width, and volume changes in osmotically stressed myocytes
37. Chloride conductance in human atrial, cells
38. Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart
39. + currents
40. Swelling-induced chloride-sensitive current in canine atrial cells revealed by whole-cell patch-clamp method
41. Pharmacologic properties of the swelling-induced chloride current of dog atrial myocytes
42. Multimeric structure of C1C-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)
43. Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease
44. A chloride channel widely expressed in epithelial and non-epithelial cells
45. Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart
46. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla
47. Contribution of a swelling-activated chloride current to changes in the cardiac action potential
48. Cell swelling and ion transport pathways in cardiac myocytes
49. Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology
50. Intracellular inorganic ions in cardiac tissue
51. + pump activity in mammalian cardiac myocytes
52. - current in guinea-pig ventricular myocytes
53. A chloride current associated with swelling of cultured chick heart cells