Inhibition of RNA synthesis in vitro and cell growth by anthracycline antibiotics

Neoplasma

Volumn 48, Issue 5, 2001, Pages 412-418

  Studzian, K ^a   Wasowska, M ^a   Piestrzeniewicz, M K ^a   Wilmanska D ^a   Szmigiero, L ^a   Oszczapowicz, I ^a   Gniazdowski, M ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Amidino anthracyclines; Cytotoxicity; Daunorubicin; Doxorubicin; HPLC; Transcription

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; DACTINOMYCIN; DAUNORUBICIN; DAUNOSAMINE; DITHIOTHREITOL; DOXORUBICIN; FERRIC ION; GUANINE; RNA; RNA POLYMERASE;

ANIMAL CELL; ARTICLE; CELL GROWTH; COVALENT BOND; CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; ENZYME ACTIVITY; MOUSE; NONHUMAN; RNA SYNTHESIS;

EID: 0035210230     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

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3. Dissection of free energy of anthracycline antibiotic binding to DNA: Electrostatic contributions
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15. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells
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17. A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: Application to the design of antitumor drugs for resistant cancer
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22. Characterization of covalent Adriamycin-DNA adducts