Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 5, 2001, Pages 199-212

  Einer Jensen, Niels ^a   Larsen, Lise ^b   Deprez, Stephanie ^b   Starns, Elaine ^a   Schwartz, Sheila ^a,b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

COPD; Ipratropium; Muscarinic antagonist; Pharmacokinetics; Tiotropium

Indexed keywords

ATROPINE; BRONCHODILATING AGENT; CARBON 14; CHOLINERGIC RECEPTOR BLOCKING AGENT; IPRATROPIUM BROMIDE; TIOTROPIUM BROMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FEMALE; MALE; NONHUMAN; RADIOACTIVITY; RAT; TIME; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; CHOLINERGIC ANTAGONISTS; DOGS; FEMALE; IPRATROPIUM; MALE; RATS; RATS, WISTAR; SCOPOLAMINE DERIVATIVES; TISSUE DISTRIBUTION;

EID: 0035207047     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.280     Document Type: Article

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