The role of interleukin-6 (IL-6) in human sulfur mustard (HD) toxicology

International Journal of Toxicology

Volumn 20, Issue 5, 2001, Pages 281-296

  Arroyo, Carmen M ^a   Broomfield, Clarence A ^a   Hackley, Brennie E ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Human Skin Cells Tissue; Interleukin 6; NMR Spectroscopy; PCR; SELDI; Sulfur Mustard (HD)

Indexed keywords

DISULFIDE; INTERLEUKIN 6; MONOCLONAL ANTIBODY; MUSTARD GAS;

ADULT; ARTICLE; BLISTER; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KERATINOCYTE; MASS SPECTROMETRY; NUCLEAR OVERHAUSER EFFECT; POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; SKIN IRRITATION; STRUCTURE ANALYSIS;

ADULT; ANTIBODIES, MONOCLONAL; CELL LINE; CELLS, CULTURED; DERMATOLOGIC AGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLASTS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-6; KERATINOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MUSTARD GAS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN;

EID: 0035205018     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158101753253027     Document Type: Article

References (50)

1. Interleukin-6 in biology and medicine
2. Role of cytokine and nitric oxide in the inflammatory response produced by sulfur mustard (HD)
3. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure
4. Response of normal human keratinocytes to sulfur mustard: Cytokine release
5. Activation of alpha-human tumour necrosis factor (TNF-alpha) by human monocytes (THP-1) exposed to 2-chloroethyl-ethyl sulphide (H-MG)
6. Matrix-assisted laser desorption ionization mass-spectrometry of proteins
7. The modulation of skin irritation
8. Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media
9. Mustard gas crosslinking of protein through preferential alkylation of cysteines
10. Fate of interleukin-6 in the rat. Involvement of skin in its catabolism
11. Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts
12. Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor
13. Cytokines and irritant contact dermatitis
14. Putative roles of inflammation in the dermatopathology of sulfur mustard
15. Effect of sulphur mustard on the expression of urokinase in cultured 3T3 fibroblasts
16. Mammalian epidermal messenger RNA: Identification and characterization of the keratin messengers
17. L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity
18. Interleukin-6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
19. In vitro cytotoxicity assay of human epidermal keratinocytes in culture exposed to sulfur mustard
20. Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils
21. Interleukin-6 and the acute phase response
22. Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption - Ionisation affinity mass spectrometry and homology modeling: Implications for the activity of factor B
23. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia
24. Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity
25. Sulfur mustard upregulates the expression of interleukin-8 in cultured human keratinocytes
26. TNF-alpha and IL-6 are mediators in the blistering process of pemphigus
27. The role of keratinocytes cytokines in inflammation and immunity
28. Serum levels of interleukin-6 and acute phase responses
29. Site-specific mutagenesis of human interleukin-6 and its biological activity
30. MALDI-ToF/MS as a diagnostic tool for the confirmation of sulfur mustard exposure
31. Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane
32. Blister fluid cytokine in cutaneous inflammatory bullous disorders
33. Roles of disulfides bonds in recombinant human interleukin-6 conformation
34. Alteration in inflammatory cytokine gene expression in sulfur mustard exposed mouse skin
35. Colorimetric protein assay techniques
36. In vivo introduction of the interleukin 6 gene into human keratinocytes: Induction of epidermal proliferation by the fully spliced form of interleukin 6, but not by the alternatively spliced form
37. Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes
38. Vesicants
39. Role of disulfide bonds in biologic activity of human interleukin-6
40. Identifying immunogenic sites on ADEPT enzyme CPG2 using a scFv library and SELDIAMS
41. Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts
42. IL-6 Receptor
43. Chemotactic factors released in culture by intact developing and healing skin lesions produced in rabbits by the irritant sulfur mustard
44. The cytokines NAP-1 (IL-8), MCP-1, IL-1 beta, and GRO in rabbit inflammatory skin lesions produced by the chemical irritant sulfur mustard
45. Interaction of interferons with skin reactive cytokines: From interleukin-1 to interleukin-8
46. Interleukin-6: An overview
47. Pathogenesis of skin lesions caused by sulfur mustard
48. Clinical management of mustard gas casualties
49. Extracellular collagenase, proteoglycanase and products of their activity, released in organ culture by intact dermal inflammatory lesions produced by sulfur mustard