Regulation of microglia by CD4+ and CD8+ T cells: Selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras

Brain Pathology

Volumn 11, Issue 1, 2001, Pages 44-55

  Schlúter, Dirk ^a   Meyer, Timothy ^a,b   Strack, Andreas ^b   Reiter, Sabine ^a,b   Kretschmar, Marianne ^a   Wiestler, Otmar D ^b   Hof, Herbert ^a   Deckert, Martina ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ENCEPHALITIS; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNE RESPONSE; MICROGLIA; MOUSE; NONHUMAN; PHENOTYPE; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0035204988     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2001.tb00380.x     Document Type: Article

References (40)

1. Human immunodeficiency virus infection in microglia: Correlation between cells infected in the brain and cells cultured from infectious brain tissue
2. Mature microglia resemble immature antigen-presenting cells
3. Role of TNF and IL-1 in infections with Toxoplasma gondii
4. Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells
5. Human microglial cell defense against Toxoplasma gondii. The role of cytokines
6. Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, Mac-1, CD43, VLA-4, and MHC class II antigens in murine Toxoplasma encephalitis: A light microscopic and ultrastructural immunohistochemical study
7. Interferon-γ receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation
8. Interleukin-10 downregulates the intracerebal immune response in chronic Toxoplasma encephalitis
9. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
10. Interferon-γ, but not tumor necrosis factor, is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis
11. Induction and regulation of IL-15 expression in murine macrophages
12. Functional dichotomy of mouse microglia developed in vitro: Differential effects of macrophage and granulocyte/macrophage colony-stimulating factor on cytokine secretion and antitoxoplasmic activity
13. Microglia induce CD4 T lymphocyte final efector function and death
14. Immunobiology of microglial cells
15. + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii
16. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages
17. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts
18. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
19. Parasite-induced IL-12 stimulates early IFN-γ-synthesis and resistance during acute infection with Toxoplasma gondii
20. Impairment of the cellular immune responses in acute murine toxoplasmosis: Regulation of interleukin 2 production and macrophage-mediated inhibitory effects
21. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
22. Bone marrow-derived elements in the central nervous system: An immunohistochemical and ultrastructural survey of rat chimeras
23. + T cell-mediated immunity against Toxoplasma gondii infection in mice
24. A dichotomous role of nitric oxide during acute Toxoplasma gondii infection in mice
25. + T cell cytokine profile in experimental allergic encephalomyelitis
26. Morphology and distribution of HIV gp41 positive microglia in subacute AIDS encephalitis: Pattern of involvement resembling a multisystem degeneration
27. IFN-γ-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-α
28. Toxoplasmic encephalitis
29. The role of tumor necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the central nervous system
30. L-arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes
31. Tumor necrosis factor-α: A neuromodulator in the CNS
32. Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function
33. TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines
34. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
35. Toxoplasma encephalitis of immunocompetent and nude mice: Immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products
36. Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected brain
37. Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice
38. Isolation and characterization of resident microglial cells from the normal and inflamed central nervous system
39. Interferon-γ: The major mediator of resistance against Toxoplasma gondii
40. Importance of IFN-γ for prevention of toxoplasmic encephalitis in mice