Differences between in vitro and in vivo determinations of fluvoxamine-clozapine interaction [7]

Journal of Clinical Psychopharmacology

Volumn 21, Issue 6, 2001, Pages 625-626

  Lu, M L ^a   Lane, H Y ^a   Chang, W H ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; FLUVOXAMINE;

CONCENTRATION RESPONSE; DEMETHYLATION; DRUG DETERMINATION; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LETTER; OXIDATION; PATIENT MONITORING; PRIORITY JOURNAL; SCHIZOPHRENIA;

CLOZAPINE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; FLUVOXAMINE; HUMANS; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0035204737     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-200112000-00020     Document Type: Letter

References (9)

1. Fluvoxamine-clozapine drug interaction: Inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism
2. In vitro and in vivo evaluation of the drug-drug interaction between fluvoxamine and clozapine
3. Fluvoxamine to reduce the need for clozapine in refractory schizophrenic patients
4. Relationship of in vitro on drug metabolism to in vivo pharmacokinetics and drug interactions: Implications for diazepam disposition in humans
5. Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: Differential effects of fluvoxamine and paroxetine in a prospective study
6. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
7. Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele
8. Low frequency of slow debrisoquine hydroxylation in native Chinese population
9. Low frequency of dextromethorphan O-demethylation deficiency in a Chinese population