Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients

American Journal of Physiology - Endocrinology and Metabolism

Volumn 281, Issue 5 44-5, 2001, Pages

  Russell III, Raymond R ^a   Chyun, Deborah ^c   Song, Steven ^a   Sherwin, Robert S ^a   Tamborlane, William V ^a,b   Lee, Forrester A ^a   Pfeifer, Michael A ^d   Rife, Frances ^a   Wackers, Frans J T ^a   Young, Lawrence H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF NURSING   (United States)

^c YALE UNIVERSITY   (United States)

^d EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Diastolic function; Left ventricular ejection fraction

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 123; CARBON 11; EPHEDRINE DERIVATIVE; GLUCOSE; INSULIN; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M;

ADULT; ARTICLE; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLE; EXERCISE TEST; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART SCINTISCANNING; HEMODYNAMIC PARAMETERS; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; INFUSION PUMP; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0035203312     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.281.5.e1029     Document Type: Article

References (34)

1. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release
2. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
3. Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance
4. Insulin differentially regulates systemic and skeletal muscle vascular resistance
5. Triple control of relaxation: Implications in cardiac disease
6. Dual control of relaxation: Its role in ventricular function in the mammalian heart
7. Counterregulation of hypoglycemia. Skeletal muscle glycogen metabolism during three hours of physiological hyperinsulinemia in humans
8. Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. A vicious cycle
9. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia
10. Left ventricular diastolic function in young long-term type 1 (insulin-dependent) diabetic men during exercise assessed by digitized echocardiography
11. The Diabetes Control and Complications Trial (DCCT). Design and methodologic considerations for the feasibility phase
12. Insulin resistance is a prominent feature of insulin-dependent diabetes
13. Glucose clamp technique: A method for quantifying insulin secretion and resistance
14. Comparison of left ventricular function in insulin- and non-insulin-dependent diabetes mellitus
15. The effects of insulin-induced hypoglycaemia on cardiovascular function in normal man: Studies using radionuclide ventriculography
16. Cardiac responses to acute insulin-induced hypoglycemia in humans
17. RR-variation: The autonomic test of choice in diabetes
18. Haemodynamic changes in insulin-induced hypoglycaemia in normal man
19. Radionuclide assessment of left ventricular diastolic filling in diabetes mellitus with and without cardiac autonomic neuropathy
20. Impaired counterregulation of hypoglycemia in insulin-dependent diabetes mellitus
21. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
22. Rapid radionuclide derived systolic and diastolic cardiac function using cycle-dependent background correction and Fourier analysis
23. A simple test of cardiac function based upon the heart rate changes induced by the Valsalva maneuver
24. Left ventricular volume calculation using a count-based ratio method applied to multigated radionuclide angiography
25. Autonomic and hemodynamic responses to insulin in lean and obese humans
26. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man
27. Hypoglycemia-induced autonomic failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation
28. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man
29. Insulin as a vascular and sympathoexcitatory hormone: Implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity
30. 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients
31. Diabetic autonomic neuropathy-Part I. Autonomic nervous system data analysis by a computerized central unit in a multicenter trial
32. Myocardial dysfunction and adrenergic cardiac innervation in patients with insulin-dependent diabetes mellitus
33. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
34. Cardiac sympathetic dysinnervation in diabetes: Implications for enhanced cardiovascular risk