Hyperlactatemia and lactic acidosis during antiretroviral therapy: Causes, management and possible ætiologies

AIDS Reviews

Volumn 3, Issue 3, 2001, Pages 150-156

  Moyle, G ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Hyperlactatemia; Lactic acidosis; Nucleoside analogs

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; BICARBONATE; CARNITINE; DIDANOSINE; DNA DIRECTED DNA POLYMERASE GAMMA; GLUCOSE; HEMOGLOBIN; INSULIN; LACTIC ACID; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; METFORMIN; MITOCHONDRIAL DNA; NEVIRAPINE; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; PROTON; RIBOFLAVIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; THIAMINE; THYMIDINE DERIVATIVE; UBIDECARENONE; UBIQUINONE; UNINDEXED DRUG; VALPROIC ACID; ZALCITABINE; ZIDOVUDINE;

ANAEROBIC METABOLISM; BLOOD PH; CELL DAMAGE; CLEARANCE; CLINICAL TRIAL; CYTOSOL; DRUG FATALITY; ENERGY; ENZYME INHIBITION; EXERCISE; HEALTH SURVEY; HEART DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERINSULINEMIA; HYPERLACTATEMIA; HYPERMETABOLISM; HYPOXIA; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LONG TERM CARE; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PATIENT MONITORING; PROTEIN DEPLETION; REST; REVIEW; SYMPTOM; TOXICITY TESTING;

EID: 0035202444     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

1. Lactic acidosis revisited
2. Controversies in lactic acidosis
3. The origin of acidosis in hyperlactataemia
4. Pathogenesis and management of lactic acidosis
5. Lactic acidosis update for critical care clinicians
6. Definition of clinically relevant lactic acidosis in patients with internal diseases
7. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational NRTI for chronic hepatitis B
8. Anti-HIV nucleoside and nucleotide analogues (NA) and mitochondria: Is all NA toxicity mitochondrial toxicity?
9. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy
10. Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy
11. Management of hyperlactatemia: No need for routine lactate measurements
12. Hyperlactatemia and hepatic abnormalities in ten HIV-infected patients receiving nucleoside combination regimens
13. Lactic acidosis (LA) in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs)
14. Hyperlactatemia during antiretroviral therapy: Does nucleoside analogue choice matter?
15. Contra-indications to metformin therapy are largely disregarded
16. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
17. Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
18. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group
19. Sodium bicarbonate for the treatment of lactic acidosis
20. Riboflavin to treat NRTI induced lactic acidosis
21. Riboflavine and severe lactic acidosis
22. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: Lactic acidosis, risk factors and therapeutic options
23. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: Report of two patients and review of the literature
24. Symptomatic hyperlactatemia: An emerging complication of antiretroviral therapy
25. Lactic acidosis: A new insight?
26. Dysregulation of lipid turnover is a key defect in the lipodystrophy syndrome
27. Lipodystrophy in HIV-infected subjects on PI-based HAART is associated with increased endogenous glucose production and both peripheral and hepatic insulin resistance
28. Differences in postprandial lipid metabolism in patients with PI-associated and NRTI-associated lipodystrophy
29. Effects of hyperinsulinaemia and hyperglycaemia on lactate release and local blood flow in subcutaneous adipose tissue of healthy humans
30. Role of Na+-K+-ATPase in the insulin-induced lactate release by skeletal muscle
31. Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells