Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type

Anti-Cancer Drug Design

Volumn 16, Issue 1, 2001, Pages 37-47

  Baston, E ^a   Klein, C D P ^a   Grimminger, W ^a   Hebecker, N ^a   Hartmann, R W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aminoglutethimide Analogues; Aromatase inhibitors; Breast cancer; In vivo activity; P450 18; P450 arom; P450 scc; QSAR

Indexed keywords

2 CYCLOHEXYLETHYL 3 (4 AMINOPHENYL)PIPERIDINE 2,6 DIONE; AMINOGLUTETHIMIDE; ANASTROZOLE; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; CYCLOPENTYLMETHYL 3 (4 AMINOPHENYL)PIPERIDINE 2,6 DIONE; CYTOCHROME P450; FADROZOLE; LETROZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; IC 50; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; UTERUS GROWTH;

ADULT; ANDROGEN ANTAGONISTS; ANIMALS; AROMATASE INHIBITORS; CATTLE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; ENZYME INHIBITORS; FEMALE; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; PIPERIDINES; PLACENTA; PREGNANCY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; STEROIDS; UTERUS;

ANIMALIA;

EID: 0035195755     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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