Differential induction of peroxisomal β-oxidation enzymes by clofibric acid and aspirin in piglet tissues

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 281, Issue 5 50-5, 2001, Pages

  Xing Xian Yu, ^a   Odle, J ^a   Drackley, J K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Carnitine palmitoyltransferase; Fatty acids; Fatty acyl coenzyme A oxidase; Peroxisome proliferators; Pigs

Indexed keywords

ACETYLSALICYLIC ACID; ACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE; CATALASE; CLOFIBRIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME INDUCTION; FATTY ACID OXIDATION; HEART WEIGHT; KIDNEY MASS; LIVER WEIGHT; MILK; NEWBORN; NONHUMAN; NORTHERN BLOTTING; OXIDATION; PEROXISOME; PRIORITY JOURNAL; SPECIES DIFFERENCE; SWINE; TISSUE SPECIFICITY;

EID: 0035195482     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2001.281.5.r1553     Document Type: Article

References (63)

1. 2 uptake, and β- oxidation
2. Plasma β-hydroxybutyrate after octanoate challenge: Attenuated ketogenic capacity in neonatal swine
3. Molecular basis of non-responsiveness to peroxisome proliferators: The guinea-pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia
4. Studies on the development of carnitine palmitoyltransferase and fatty acid oxidation in liver mitochondria of neonatal pigs
5. Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients
6. Fatty acids mediate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α
7. Acyl-CoA synthetase and the peroxisomal enzymes of β-oxidation in human liver
8. Effects of acetylsalicylic acid on parameters related to peroxisome proliferation in mouse liver
9. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
10. Positive regulation of the peroxisomal β-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
11. Hepatic ketogenesis in newborn pigs is limited by low mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity
12. The effect of the hypocholesterolemic drug clofibrate on liver mitochondrial biogenesis: A role for neutral mitochondrial proteases
13. Adaptations of glucose and fatty acid metabolism during the perinatal period and suckling-weaning transition
14. Morphological and functional modifications of rat liver peroxisomal subpopulations during cold exposure
15. Quantitative microscopy comparison of peroxisome proliferation by the lipid-regulating agent gemfibrozil in several species
16. Characterization of porcine peroxisome proliferator-activated receptor γ1 and γ2: Detection of breed and age differences in gene expression
17. Peroxisomal β-oxidation of fatty acids in bovine and rat liver
18. Relationship between morphological changes and lipid lowering action of p-chlorophenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man
19. Individual peroxisomal β-oxidation enzymes
20. The effect of peroxisome proliferators on microsomal, peroxisomal, and mitochondrial enzyme activities in the liver and kidney
21. Peroxisome proliferator-activated receptor alpha: Role in rodent liver cancer and species differences
22. Detection of peroxisomal fatty acyl-coenzyme A oxidase activity
23. Effects of clofibric acid and tiadenol on cytosolic long-chain acyl-CoA hydrolase and peroxisomal β-oxidation in liver and extrahepatic tissues of rats
24. Induction of omega-oxidation of monocarboxylic acids in rats by acetylsalicylic acid
25. Increase in hepatic mitochondria on administration of ethyl-α-p-chlorophenoxyisobutyrate to the rat
26. The peroxisomal β-oxidation enzyme system of rat heart. Basal level and effect of the peroxisome proliferator clofibrate
27. Comparative studies on DEHP induced hepatic peroxisome proliferation in rat and hamster
28. A fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement by clofibrate, a hypolipidemic drug
29. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
30. Comparison of constitutive and inducible levels of expression of peroxisomal β-oxidation and catalase genes in liver and extrahepatic tissues of rat
31. Increased β-oxidation of erucic acid in perfused hearts from rats fed clofibrate
32. Carnitine palmitoyltransferase modulation of hepatic fatty acid metabolism and radio-HPLC evidence for low ketogenesis in neonatal pigs
33. Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: Characterization of a peroxisome proliferator-responsive element
34. Clobuzarit: Species differences in the morphological and biochemical response of the liver following chronic administration
35. Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification
36. Hepatic and renal effects of peroxisome proliferators: Biological implications
37. Dietary clofibric acid increases intestinal fatty acid binding protein activity and apparent lipid digestibility in weanling swine
38. The effect of di(ethylhexyl)phthalate on fatty acid oxidation and carnitine palmitoyltransferase in various rat tissues
39. Differences in the formation of PPARα-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration
40. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
41. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
42. Differential induction of peroxisomal and microsomal fatty-acid-oxidizing enzymes by peroxisome proliferators in rat liver and kidney
43. Biochemistry of peroxisomes in health and disease
44. Morphometric analysis of liver and kidney peroxisomes in lactating rats and their pups after treatment with the peroxisomal proliferator di-(2-ethylexy)phthalate
45. Species-dependent induction of peroxisome proliferation by haloxyfop, an aryloxyphenoxy herbicide
46. Peroxisome proliferator activated receptor α (PPARα) expression in swine: Detection of an alternative transcript
47. Morphogenesis and development of microbodies of hepatocytes of rats during pre- and post-natal growth
48. Fluorometric assay of peroxisomal oxidases
49. Peroxisomal proliferation in heart and liver of mice receiving chlorpromazine, ethyl 2(5(4-chlorophenyl)pentyl)oxiran-2-carboxylic acid or high fat diet: A biochemical and morphometrical comparative study
50. Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on the liver and heart peroxisomal and mitochondrial β-oxidation
51. Peroxisomal fatty acid oxidation in rat and human tissues. Effect of nutritional state, clofibrate treatment and postnatal development in the rat
52. Change of the sex-dependent response to clofibrate in F 344 rat liver during postnatal development
53. Rates of mitochondrial and peroxisomal β-oxidation of palmitate changes during postnatal development and feed deprivation in liver, kidney, and heart of pigs
54. Food deprivation changes peroxisomal β-oxidation activity but not catalase activity during postnatal development in pig tissues
55. Response of hepatic mitochondrial and peroxisomal β-oxidation to increasing palmitate concentrations in piglets
56. Carnitine acyltransferases: Functional significance of subcellular distribution, and membrane topology