Can down-regulation of UDP-glucuronosyltransferases in the urinary bladder tissue impact the risk of chemical carcinogenesis? [2]

International Journal of Cancer

Volumn 91, Issue 1, 2001, Pages 141-143

  Giuliani, Laura ^a   Gazzaniga, Paola ^a   Caporuscio, Francesca ^a   Ciotti, Marco ^b   Frati, Luigi ^a,c   Aglianò, Anna Maria ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE;

BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER RISK; CHEMICAL CARCINOGENESIS; CHROMOSOME DELETION; CONTROLLED STUDY; DNA ADDUCT; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; HUMAN; HUMAN TISSUE; LETTER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

BIOPSY; CARCINOMA, TRANSITIONAL CELL; DOWN-REGULATION; GLUCURONOSYLTRANSFERASE; HUMANS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 0035195471     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20010101)91:1<141::AID-IJC1005>3.0.CO;2-H     Document Type: Letter

References (19)

1. Bladder cancer
2. Blasengeschwulste bei fuchsin-arbeitern
3. Tobacco and bladder cancer in males: Increased risk for inhalers and smokers of black tobacco
4. Chemical studies on tobacco smoke. LXIV. On the analysis of aromatic amines in cigarette smoke
5. Mutagenic activation of 4-aminobyphenyl and its N-hydroxy derivatives by microsomes from cultured human uroepithelial cells
6. A molecular genetic model of human bladder carcinogenesis
7. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1A4 protein
8. Glucuronidation of benzidine and its metabolites by cDNA expressed human UDP-glucuronosyltransferases and pH stability of glucuronides
9. Tissue distribution of drug-metabolism enzymes in humans
10. The role of conjugation reactions in detoxification
11. The UDPglucuronosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
12. Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation
13. Glucuronidation of N-hydroxy metabolites of N-acetylbenzidine
14. Human and Escherichia coli β-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites
15. Peroxygenase metabolism of N-acetylbenzidine by prostaglandin H synthase
16. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
17. Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ
18. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A1, UGT2B) in human oesophagus