Heterogeneity of metabolic parameters in the left ventricular myocardium and its relation to local blood flow

Basic Research in Cardiology

Volumn 96, Issue 6, 2001, Pages 564-574

  Deussen, Andreas ^a   Lauer, Thomas ^a   Loncar, Robert ^b   Kropp, Joachim ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Adenosine; Aerobic metabolism; Citric acid cycle; Coronary stenosis; Fatty acid uptake; Glycolysis; Ischemia; Lactate; Noradrenaline; Oxidation water; Sympathetic system

Indexed keywords

ADENOSINE; CITRIC ACID; ENZYME; FATTY ACID; GLUCOSE; LACTIC ACID; NORADRENALIN;

ADRENERGIC SYSTEM; AEROBIC METABOLISM; ARTICLE; BLOOD FLOW; CITRIC ACID CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; ENZYME ACTIVITY; ENZYME SUBSTRATE; FATTY ACID TRANSPORT; GLUCOSE TRANSPORT; GLYCOLYSIS; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE REPERFUSION; HUMAN; HUMAN TISSUE; MATHEMATICAL MODEL; METABOLITE; PHYSIOLOGY; TISSUE LEVEL;

ANIMALS; CORONARY CIRCULATION; ENERGY METABOLISM; HEART; MYOCARDIUM; VENTRICULAR FUNCTION, LEFT;

EID: 0035195098     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950170008     Document Type: Article

References (61)

1. Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow
2. Fractal nature of regional myocardial blood flow heterogeneity
3. Heterogeneities in myocardial flow and metabolism: Exacerbation with abnormal excitation
4. Low- and high-blood flow regions in the normal pig heart are equally vulnerable to ischaemia during partial coronary stenosis
5. Local mitochondrial enzyme activity correlates with myocardial blood flow at basal workloads
6. Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronary occlusion
7. Regional myocardial flow and capillary permeability-surface area products are nearly proportional
8. Transmural gradient of glycogen metabolism in the normal rat left ventricle
9. Spatial heterogeneity of myocardial perfusion and metabolism
10. Spatial heterogeneity of myocardial blood flow is related to local protein expression
11. Spatial heterogeneity of energy turnover in the heart
12. Blood flow heterogeneity in the heart
13. Metabolic flux rates of adenosine in the heart
14. Spatial heterogeneity of blood flow in the dog heart. II. Temporal stability in response to adrenergic stimulation
15. Modeling [15O] oxygen tracer data for estimating oxygen consumption
16. Local myocardial glucose uptake is proportional to, but not dependent on blood flow
17. Formation of S-adenosylhomocysteine in the heart. II: A sensitive index for regional myocardial underperfusion
18. Relative error and variability in blood flow measurements with radiolabeled microspheres
19. Temporal heterogeneity of myocardial blood flow in anesthetized dogs
20. Spatial heterogeneity of local blood flow and metabolite content in dog hearts
21. Spatial heterogeneity of myocardial blood flow presages salvage versus necrosis with coronary artery reperfusion in conscious baboons
22. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion
23. Heterogeneities in regional volumes of distribution and flows in rabbit heart
24. Correlation of heterogeneous blood flow and fatty acid uptake in the normal dog heart
25. Blood flow measurements with radionuclide-labeled particles
26. Heterogeneity of myocardial blood flow
27. A stochastic model for the self-similar heterogeneity of regional organ blood flow
28. Stability of heterogeneity of myocardial blood flow in normal awake baboons
29. Measurement of regional myocardial blood flow with multiple colored microspheres
30. Transmural variation in the relationship between myocardial infarct size and risk area
31. Comprehensive model of transport and metabolism of adenosine and S-adenosylhomocysteine in the guinea pig heart
32. Comparison of myocardial ATP, blood flow, and cytosolic adenosine in demand ischemia and coronary occlusion
33. Modeling regional myocardial flows from residue functions of an intravascular indicator
34. Correlation between regional flow and metabolism in dog hearts in vivo
35. Determinants of the S-adenosylhomocysteine (SAH) technique for the local assessment of cardiac free cytosolic adenosine
36. Coronary reserve of high- and low-flow regions in the dog heart left ventricle
37. Regional myocardial heat-shock protein (HSP70) concentrations under different blood flow conditions
38. Myocardial ferritin concentration, a novel sensitive marker of ischemia
39. Microheterogeneity of myocardial blood flow in rabbit hearts during normoxic and hypoxic states
40. The microsphere method facilitates statistical assessment of regional blood flow
41. Effect of isoproterenol on the relationship between regional cyclic AMP and local coronary blood flow in the canine myocardium
42. Relationship between local myocardial adenylyl cyclase activity and local coronary blood flow in the dog heart
43. Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone"
44. Experimental coronary artery occlusion. II. Spatial and temporal evolution of infarcts in the dog heart
45. Heterogeneity of local myocardial flow and oxidative metabolism
46. Heterogeneity of DMIPP uptake and its relationship with heterogeneous myocardial blood flow
47. Spatial heterogeneity of blood flow in the dog heart. I. Glucose uptake, free adenosine and oxidative/glycolytic enzyme activity
48. Heterogeneity of the hypoxic state in perfused rat heart
49. Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase
50. Relationship between beta-adrenoceptors and coronary blood flow heterogeneity
51. The microvascular unit size for fractal flow heterogeneity relevant for oxygen transport
52. A (13)C NMR double-labeling method to quantitate local myocardial O(2) consumption using frozen tissue samples
53. Transmural differences in energy metabolism of the left ventricular myocardium: Fact or fiction
54. Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine
55. Relationship between myocardial tissue norepinephrine and coronary flow heterogeneity
56. Capillary perfusion pattern and microvascular geometry in heterogeneous hypoxic areas of hypoperfused rat myocardium
57. Role of beta-1 adrenergic receptors in the control of the heterogeneity of O2 saturation in small myocardial veins
58. Quantitative determination of regional oxygen consumption in the dog heart
59. Regional oxygen saturation of small arteries and veins in the canine myocardium
60. Assessing myocardial perfusion in coronary artery disease with magnetic resonance first-pass imaging
61. Functional heterogeneity of oxygen supply-consumption ratio in the heart