Assessment of the intraocular pressure-lowering activity of bicyclic derivatives of 1-substituted benzyloctahydroisoquinoline

Journal of Ocular Pharmacology and Therapeutics

Volumn 17, Issue 5, 2001, Pages 413-420

  Saha, S L ^a   Igbo, I N ^a   Opere, C A ^a   Zhan, G L ^a   Tanimaya, J ^a   Ohia, S E ^a   Roche, V F ^a  

^a CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; BENZYLOCTAHYDROISOQUINOLINE DERIVATIVE; BICYCLO COMPOUND; CHLORINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; METHYL GROUP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE ABNORMALITY; MALE; MASS SPECTROMETRY; METHYLATION; MOLECULAR BIOLOGY; NONHUMAN; RABBIT; REBOUND; SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS; EYE; INTRAOCULAR PRESSURE; ISOQUINOLINES; MALE; MOLECULAR STRUCTURE; RABBITS;

EID: 0035194687     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/108076801753266794     Document Type: Article

References (6)

1. Bicyclic derivates of hexahydroaporphine that lower intraocular pressure
2. Mechanism of intraocular pressure-lowering activity of bicyclic analogs of hexahydroaporphine
3. Pre- and post-junctional effects of a bicyclic hexahydroaporphine in the bovine isolated iris
4. Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea, and in human platelets: Relationship to trimetoquinol
5. Identification of two serine residues involved in agonist activation of the β-adrenergic receptor
6. Studies in the synthesis of C ring bridged morphinans 2. The synthesis and structural verification of a novel 3, 11c-ethano-10-hydroxy-6-methyl-1, 2, 3, 3a, 11b, 11c-hexahydroaporphine